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- W2119514671 abstract "Cancer stem cells (CSCs) are a subpopulation of tumor cells with indefinite proliferative potential that drive the growth of tumors. CSCs seem to provide a suitable explanation for several intriguing aspects of cancer pathophysiology.An explosion of therapeutic options for cancer treatment that selectively target CSCs has been recorded in the recent years. These include the targeting of cell-surface proteins, various activated signalling pathways, different molecules of the stem cell niche and various drug resistance mechanisms. Importantly, approaching cancer research by investigating the pathogenesis of these intriguing cancer cells is increasing the knowledge of the pathophysiology of the disease, emphasizing certain molecular mechanisms that have been partially neglected.The characterization of the molecular phenotype of these cancer stem-like cells, associated with an accurate definition of their typical derangement in cell differentiation, can represent a fundamental advance in terms of diagnosis and therapy of cancer. Preliminary results seem to be promising but further studies are required to define the therapeutic index of this new anticancer treatment. Moreover, understanding the pathogenetic mechanisms of CSCs can expand the therapeutic applications of normal adult stem cells by reducing the risk of uncontrolled tumorigenic stem cell differentiation." @default.
- W2119514671 created "2016-06-24" @default.
- W2119514671 creator A5016201118 @default.
- W2119514671 creator A5034320925 @default.
- W2119514671 creator A5068160952 @default.
- W2119514671 creator A5069384526 @default.
- W2119514671 date "2011-03-30" @default.
- W2119514671 modified "2023-09-29" @default.
- W2119514671 title "Cancer stem cells: the development of new cancer therapeutics" @default.
- W2119514671 cites W127246327 @default.
- W2119514671 cites W1542949307 @default.
- W2119514671 cites W1823452785 @default.
- W2119514671 cites W1845752854 @default.
- W2119514671 cites W1963493384 @default.
- W2119514671 cites W1965431780 @default.
- W2119514671 cites W1965912618 @default.
- W2119514671 cites W1970342864 @default.
- W2119514671 cites W1973648602 @default.
- W2119514671 cites W1977202771 @default.
- W2119514671 cites W1978683990 @default.
- W2119514671 cites W1979421565 @default.
- W2119514671 cites W1980825754 @default.
- W2119514671 cites W1982321597 @default.
- W2119514671 cites W1990261336 @default.
- W2119514671 cites W1990633837 @default.
- W2119514671 cites W1993325062 @default.
- W2119514671 cites W1999249231 @default.
- W2119514671 cites W2001461804 @default.
- W2119514671 cites W2006417807 @default.
- W2119514671 cites W2009833366 @default.
- W2119514671 cites W2009886857 @default.
- W2119514671 cites W2009975733 @default.
- W2119514671 cites W2014906674 @default.
- W2119514671 cites W2015327877 @default.
- W2119514671 cites W2015831734 @default.
- W2119514671 cites W2016576372 @default.
- W2119514671 cites W2017100259 @default.
- W2119514671 cites W2019199359 @default.
- W2119514671 cites W2020164552 @default.
- W2119514671 cites W2023427658 @default.
- W2119514671 cites W2024760455 @default.
- W2119514671 cites W2029470215 @default.
- W2119514671 cites W2033151149 @default.
- W2119514671 cites W2035576418 @default.
- W2119514671 cites W2035704783 @default.
- W2119514671 cites W2036639619 @default.
- W2119514671 cites W2037394376 @default.
- W2119514671 cites W2045732172 @default.
- W2119514671 cites W2045992174 @default.
- W2119514671 cites W2047325328 @default.
- W2119514671 cites W2049016944 @default.
- W2119514671 cites W2049412884 @default.
- W2119514671 cites W2049820663 @default.
- W2119514671 cites W2051413562 @default.
- W2119514671 cites W2052296002 @default.
- W2119514671 cites W2053413169 @default.
- W2119514671 cites W2056381229 @default.
- W2119514671 cites W2056772956 @default.
- W2119514671 cites W2057731056 @default.
- W2119514671 cites W2058948883 @default.
- W2119514671 cites W2061357915 @default.
- W2119514671 cites W2063486604 @default.
- W2119514671 cites W2067942082 @default.
- W2119514671 cites W2068942546 @default.
- W2119514671 cites W2069907205 @default.
- W2119514671 cites W2070387456 @default.
- W2119514671 cites W2072778582 @default.
- W2119514671 cites W2078576160 @default.
- W2119514671 cites W2081028905 @default.
- W2119514671 cites W2082823320 @default.
- W2119514671 cites W2085380807 @default.
- W2119514671 cites W2086384126 @default.
- W2119514671 cites W2087762900 @default.
- W2119514671 cites W2091022798 @default.
- W2119514671 cites W2095811457 @default.
- W2119514671 cites W2096415778 @default.
- W2119514671 cites W2097308038 @default.
- W2119514671 cites W2098456531 @default.
- W2119514671 cites W2098607263 @default.
- W2119514671 cites W2098703221 @default.
- W2119514671 cites W2099626273 @default.
- W2119514671 cites W2101918466 @default.
- W2119514671 cites W2102042943 @default.
- W2119514671 cites W2102085111 @default.
- W2119514671 cites W2102394111 @default.
- W2119514671 cites W2104800372 @default.
- W2119514671 cites W2108388128 @default.
- W2119514671 cites W2110377632 @default.
- W2119514671 cites W2112180572 @default.
- W2119514671 cites W2112703519 @default.
- W2119514671 cites W2113337076 @default.
- W2119514671 cites W2114921350 @default.
- W2119514671 cites W2115001053 @default.
- W2119514671 cites W2120656656 @default.
- W2119514671 cites W2121017846 @default.
- W2119514671 cites W2121099713 @default.
- W2119514671 cites W2123074057 @default.
- W2119514671 cites W2123319721 @default.