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- W2119554941 abstract "Curcumin is a polyphenol derived from turmeric with recognized antioxidant properties. Hexavalent chromium is an environmental toxic and carcinogen compound that induces oxidative stress. The objective of this study was to evaluate the potential protective effect of curcumin on the hepatic damage generated by potassium dichromate (K 2 Cr 2 O 7 ) in rats. Animals were pretreated daily by 9-10 days with curcumin (400 mg/kg b.w.) before the injection of a single intraperitoneal of K 2 Cr 2 O 7 (15 mg/kg b.w.). Groups of animals were sacrificed 24 and 48 h later. K 2 Cr 2 O 7 -induced damage to the liver was evident by histological alterations and increase in the liver weight and in the activity of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase in plasma. In addition, K 2 Cr 2 O 7 induced oxidative damage in liver and isolated mitochondria, which was evident by the increase in the content of malondialdehyde and protein carbonyl and decrease in the glutathione content and in the activity of several antioxidant enzymes. Moreover, K 2 Cr 2 O 7 induced decrease in mitochondrial oxygen consumption, in the activity of respiratory complex I, and permeability transition pore opening. All the above-mentioned alterations were prevented by curcumin pretreatment. The beneficial effects of curcumin against K 2 Cr 2 O 7 -induced liver oxidative damage were associated with prevention of mitochondrial dysfunction." @default.
- W2119554941 created "2016-06-24" @default.
- W2119554941 creator A5003093357 @default.
- W2119554941 creator A5005490164 @default.
- W2119554941 creator A5026722432 @default.
- W2119554941 creator A5031796133 @default.
- W2119554941 creator A5037638939 @default.
- W2119554941 creator A5059846027 @default.
- W2119554941 creator A5068702152 @default.
- W2119554941 date "2013-01-01" @default.
- W2119554941 modified "2023-10-17" @default.
- W2119554941 title "Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening" @default.
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