FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119587634> ?p ?o ?g. }

• W2119587634 endingPage "2305" @default.
• W2119587634 startingPage "2291" @default.
• W2119587634 abstract "The extended synaptotagmins (E-Syts) are ER proteins that act as Ca(2+)-regulated tethers between the ER and the plasma membrane (PM) and have a putative role in lipid transport between the two membranes. Ca(2+) regulation of their tethering function, as well as the interplay of their different domains in such function, remains poorly understood. By exposing semi-intact cells to buffers of variable Ca(2+) concentrations, we found that binding of E-Syt1 to the PI(4,5)P2-rich PM critically requires its C2C and C2E domains and that the EC50 of such binding is in the low micromolar Ca(2+) range. Accordingly, E-Syt1 accumulation at ER-PM contact sites occurred only upon experimental manipulations known to achieve these levels of Ca(2+) via its influx from the extracellular medium, such as store-operated Ca(2+) entry in fibroblasts and membrane depolarization in β-cells. We also show that in spite of their very different physiological functions, membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2+)." @default.
• W2119587634 created "2016-06-24" @default.
• W2119587634 creator A5037459294 @default.
• W2119587634 creator A5061235654 @default.
• W2119587634 creator A5061775082 @default.
• W2119587634 creator A5079217136 @default.
• W2119587634 date "2015-07-22" @default.
• W2119587634 modified "2023-10-18" @default.
• W2119587634 title "Triggered Ca ²⁺ influx is required for extended synaptotagmin 1‐induced <scp>ER</scp> ‐plasma membrane tethering" @default.
• W2119587634 cites W1591133722 @default.
• W2119587634 cites W1593385535 @default.
• W2119587634 cites W1938591788 @default.
• W2119587634 cites W1958742527 @default.
• W2119587634 cites W1964375147 @default.
• W2119587634 cites W1969288514 @default.
• W2119587634 cites W1976283234 @default.
• W2119587634 cites W1976421151 @default.
• W2119587634 cites W1978302530 @default.
• W2119587634 cites W1980939512 @default.
• W2119587634 cites W1990076574 @default.
• W2119587634 cites W1992163176 @default.
• W2119587634 cites W1997142270 @default.
• W2119587634 cites W2001831734 @default.
• W2119587634 cites W2003992236 @default.
• W2119587634 cites W2012057989 @default.
• W2119587634 cites W2014005588 @default.
• W2119587634 cites W2016633763 @default.
• W2119587634 cites W2022680688 @default.
• W2119587634 cites W2030530833 @default.
• W2119587634 cites W2047612054 @default.
• W2119587634 cites W2051025707 @default.
• W2119587634 cites W2051420724 @default.
• W2119587634 cites W2059412195 @default.
• W2119587634 cites W2060259273 @default.
• W2119587634 cites W2060384627 @default.
• W2119587634 cites W2062699559 @default.
• W2119587634 cites W2066781376 @default.
• W2119587634 cites W2073405263 @default.
• W2119587634 cites W2093883442 @default.
• W2119587634 cites W2102893344 @default.
• W2119587634 cites W2105729094 @default.
• W2119587634 cites W2111097328 @default.
• W2119587634 cites W2111332270 @default.
• W2119587634 cites W2115873650 @default.
• W2119587634 cites W2128292852 @default.
• W2119587634 cites W2139932131 @default.
• W2119587634 cites W2143479755 @default.
• W2119587634 cites W2143830427 @default.
• W2119587634 cites W2149528921 @default.
• W2119587634 cites W2149743336 @default.
• W2119587634 cites W2160894386 @default.
• W2119587634 cites W2165231575 @default.
• W2119587634 cites W2167279371 @default.
• W2119587634 cites W2397741376 @default.
• W2119587634 cites W4245533688 @default.
• W2119587634 doi "https://doi.org/10.15252/embj.201591565" @default.
• W2119587634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4585464" @default.
• W2119587634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26202220" @default.
• W2119587634 hasPublicationYear "2015" @default.
• W2119587634 type Work @default.
• W2119587634 sameAs 2119587634 @default.
• W2119587634 citedByCount "139" @default.
• W2119587634 countsByYear W21195876342015 @default.
• W2119587634 countsByYear W21195876342016 @default.
• W2119587634 countsByYear W21195876342017 @default.
• W2119587634 countsByYear W21195876342018 @default.
• W2119587634 countsByYear W21195876342019 @default.
• W2119587634 countsByYear W21195876342020 @default.
• W2119587634 countsByYear W21195876342021 @default.
• W2119587634 countsByYear W21195876342022 @default.
• W2119587634 countsByYear W21195876342023 @default.
• W2119587634 crossrefType "journal-article" @default.
• W2119587634 hasAuthorship W2119587634A5037459294 @default.
• W2119587634 hasAuthorship W2119587634A5061235654 @default.
• W2119587634 hasAuthorship W2119587634A5061775082 @default.
• W2119587634 hasAuthorship W2119587634A5079217136 @default.
• W2119587634 hasBestOaLocation W21195876342 @default.
• W2119587634 hasConcept C12554922 @default.
• W2119587634 hasConcept C130316041 @default.
• W2119587634 hasConcept C148785051 @default.
• W2119587634 hasConcept C181199279 @default.
• W2119587634 hasConcept C201815810 @default.
• W2119587634 hasConcept C28406088 @default.
• W2119587634 hasConcept C41625074 @default.
• W2119587634 hasConcept C55493867 @default.
• W2119587634 hasConcept C86473631 @default.
• W2119587634 hasConcept C86803240 @default.
• W2119587634 hasConcept C95444343 @default.
• W2119587634 hasConcept C98539663 @default.
• W2119587634 hasConceptScore W2119587634C12554922 @default.
• W2119587634 hasConceptScore W2119587634C130316041 @default.
• W2119587634 hasConceptScore W2119587634C148785051 @default.
• W2119587634 hasConceptScore W2119587634C181199279 @default.
• W2119587634 hasConceptScore W2119587634C201815810 @default.
• W2119587634 hasConceptScore W2119587634C28406088 @default.
• W2119587634 hasConceptScore W2119587634C41625074 @default.
• W2119587634 hasConceptScore W2119587634C55493867 @default.
• W2119587634 hasConceptScore W2119587634C86473631 @default.

• next