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- W2119599480 abstract "We present simulation results from a new computational model of DNA flow in microfluidic devices. This work is important because computational models are needed to design miniaturized biomedical devices that are becoming the state-of-the-art in many significant applications including pathogen detection as well as continuous monitoring and drug delivery. Currently advanced algorithms in design tools are non-existent but necessary to understand the complex fluid and polymer dynamics involved in biological flow at small scales. Our model is based on a fully coupled fluid-particle numerical algorithm with both stochastic and deterministic components in a bead-rod polymer representation. We have applied this work to DNA extraction configurations in a microfluidic PCR chamber used in a pathogen detection system. We demonstrate our method on the test problem of flow of a single DNA molecule in a 2D packed array microchannel. We are also investigating mechanisms for molecular sticking using short range forces." @default.
- W2119599480 created "2016-06-24" @default.
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- W2119599480 date "2005-12-10" @default.
- W2119599480 modified "2023-09-28" @default.
- W2119599480 title "Modeling and simulation of DNA flow in a microfluidic-based pathogen detection system" @default.
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- W2119599480 doi "https://doi.org/10.1109/mmb.2005.1548471" @default.
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