FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119612227> ?p ?o ?g. }

• W2119612227 endingPage "1447" @default.
• W2119612227 startingPage "1444" @default.
• W2119612227 abstract "To report a case of elevated blood tacrolimus concentration after application of topical tacrolimus ointment in an erythrodermic patient.A 44-year-old man developed generalized erythroderma and itching due to infection with human T-cell lymphotropic virus. Despite application of strong glucocorticosteroid ointments, the symptoms and area of erythroderma were not alleviated. Daily topical application of tacrolimus 0.1% ointment was added and therapeutic drug monitoring was started. The dose and applied area of tacrolimus were gradually increased from 2.5 to 12.5 g/d and from 10% to 90% of body surface area, respectively. Because the trough concentration of tacrolimus in whole blood increased from 7.5 ng/mL on treatment day 9 to 15.4 ng/mL on day 13, the dose was reduced to 10 g/d. However, the concentration further elevated to 16.5 ng/mL. Therefore, the applied area was reduced to 20% of body surface area, and the tacrolimus concentration decreased gradually thereafter. Although the transient increase of blood tacrolimus concentration was observed on day 23, treatment with 20% applied area and 5 g/d were maintained.Topically applied tacrolimus was substantially absorbed with the expansion of its applied area and dose. Increased tacrolimus concentrations may have a tendency to depend on the increase of the percent of body surface area per dose. Our findings showing the elevation of blood tacrolimus concentration after application of the ointment to a large area of the body suggest that the applied area should be as narrow as possible in a barrier-disrupted condition such as erythroderma. However, the safety of tacrolimus ointment has not been established in patients with generalized erythroderma.Tacrolimus concentrations in whole blood should be carefully monitored to prevent nephrotoxicity. Based on the results of that monitoring, the application area and dose of tacrolimus ointment should be closely adjusted, especially in generalized erythrodermic cases." @default.
• W2119612227 created "2016-06-24" @default.
• W2119612227 creator A5000785399 @default.
• W2119612227 creator A5007218728 @default.
• W2119612227 creator A5013232618 @default.
• W2119612227 creator A5023687497 @default.
• W2119612227 creator A5039054605 @default.
• W2119612227 creator A5043225877 @default.
• W2119612227 date "2003-10-01" @default.
• W2119612227 modified "2023-10-17" @default.
• W2119612227 title "Increased Topical Tacrolimus Absorption in Generalized Leukemic Erythroderma" @default.
• W2119612227 cites W1971860511 @default.
• W2119612227 cites W1972950270 @default.
• W2119612227 cites W1991393598 @default.
• W2119612227 cites W2007009297 @default.
• W2119612227 cites W2030886807 @default.
• W2119612227 cites W2071932650 @default.
• W2119612227 cites W2155569462 @default.
• W2119612227 cites W2156488305 @default.
• W2119612227 cites W2160867096 @default.
• W2119612227 doi "https://doi.org/10.1345/aph.1d082" @default.
• W2119612227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14519034" @default.
• W2119612227 hasPublicationYear "2003" @default.
• W2119612227 type Work @default.
• W2119612227 sameAs 2119612227 @default.
• W2119612227 citedByCount "14" @default.
• W2119612227 countsByYear W21196122272012 @default.
• W2119612227 countsByYear W21196122272014 @default.
• W2119612227 countsByYear W21196122272018 @default.
• W2119612227 crossrefType "journal-article" @default.
• W2119612227 hasAuthorship W2119612227A5000785399 @default.
• W2119612227 hasAuthorship W2119612227A5007218728 @default.
• W2119612227 hasAuthorship W2119612227A5013232618 @default.
• W2119612227 hasAuthorship W2119612227A5023687497 @default.
• W2119612227 hasAuthorship W2119612227A5039054605 @default.
• W2119612227 hasAuthorship W2119612227A5043225877 @default.
• W2119612227 hasConcept C126322002 @default.
• W2119612227 hasConcept C16005928 @default.
• W2119612227 hasConcept C2777501473 @default.
• W2119612227 hasConcept C2778784858 @default.
• W2119612227 hasConcept C2909675724 @default.
• W2119612227 hasConcept C2911091166 @default.
• W2119612227 hasConcept C71924100 @default.
• W2119612227 hasConcept C98274493 @default.
• W2119612227 hasConceptScore W2119612227C126322002 @default.
• W2119612227 hasConceptScore W2119612227C16005928 @default.
• W2119612227 hasConceptScore W2119612227C2777501473 @default.
• W2119612227 hasConceptScore W2119612227C2778784858 @default.
• W2119612227 hasConceptScore W2119612227C2909675724 @default.
• W2119612227 hasConceptScore W2119612227C2911091166 @default.
• W2119612227 hasConceptScore W2119612227C71924100 @default.
• W2119612227 hasConceptScore W2119612227C98274493 @default.
• W2119612227 hasIssue "10" @default.
• W2119612227 hasLocation W21196122271 @default.
• W2119612227 hasLocation W21196122272 @default.
• W2119612227 hasOpenAccess W2119612227 @default.
• W2119612227 hasPrimaryLocation W21196122271 @default.
• W2119612227 hasRelatedWork W1818772542 @default.
• W2119612227 hasRelatedWork W1975930240 @default.
• W2119612227 hasRelatedWork W2018085374 @default.
• W2119612227 hasRelatedWork W2050230731 @default.
• W2119612227 hasRelatedWork W2111975076 @default.
• W2119612227 hasRelatedWork W2391047294 @default.
• W2119612227 hasRelatedWork W3095799824 @default.
• W2119612227 hasRelatedWork W3207196874 @default.
• W2119612227 hasRelatedWork W3211572932 @default.
• W2119612227 hasRelatedWork W4200557508 @default.
• W2119612227 hasVolume "37" @default.
• W2119612227 isParatext "false" @default.
• W2119612227 isRetracted "false" @default.
• W2119612227 magId "2119612227" @default.
• W2119612227 workType "article" @default.