FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119669929> ?p ?o ?g. }

• W2119669929 endingPage "166" @default.
• W2119669929 startingPage "162" @default.
• W2119669929 abstract "Multiple myeloma (MM) is a B cell malignancy characterized by the expansion of monoclonal Ig-secreting plasma cells with low proliferative activity. It is postulated that inhibition of physiologic cell death is an underlying factor in the pathophysiology of MM. The development of chemoresistance is a common feature in patients with MM. In the present studies, hexamethylene bisacetamide (HMBA), a hybrid polar compound that is a potent inducer of terminal differentiation of various transformed cells, is shown to inhibit the growth of several human myeloma cell lines (ARP-1, U266, and RPMI 8226), including doxorubicin-resistant RPMI 8226 variants that overexpress the multidrug-resistance gene, MDR-1, and its product, p-glycoprotein. In addition to growth arrest and suppression of clonogenicity, HMBA induces apoptosis both in freshly isolated human myeloma cells and in cell lines, as determined by morphologic alterations, cell cycle distribution and endonucleosomal DNA fragmentation. Further, HMBA decreases BCL-2 protein expression in myeloma cells within 12–48 hr. Overexpression of BCL-2 protein in ARP-1 cells confers resistance to HMBA-induced apoptosis. Taken together, these data suggest that HMBA is a potent inducer of apoptosis in human myeloma cells, which may act through suppressing the anti-apoptotic function of the bcl-2 gene. HMBA, and related hybrid polar compounds, may prove useful in the management of this presently incurable disease." @default.
• W2119669929 created "2016-06-24" @default.
• W2119669929 creator A5023752321 @default.
• W2119669929 creator A5024371816 @default.
• W2119669929 creator A5027363771 @default.
• W2119669929 creator A5061964017 @default.
• W2119669929 creator A5065320270 @default.
• W2119669929 creator A5078159824 @default.
• W2119669929 creator A5079671192 @default.
• W2119669929 creator A5082113956 @default.
• W2119669929 creator A5085264531 @default.
• W2119669929 date "1998-01-06" @default.
• W2119669929 modified "2023-09-25" @default.
• W2119669929 title "Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells" @default.
• W2119669929 cites W139481359 @default.
• W2119669929 cites W1481484660 @default.
• W2119669929 cites W1483201954 @default.
• W2119669929 cites W1568814585 @default.
• W2119669929 cites W1591166893 @default.
• W2119669929 cites W1636279715 @default.
• W2119669929 cites W1652716702 @default.
• W2119669929 cites W1984866351 @default.
• W2119669929 cites W2000576198 @default.
• W2119669929 cites W2001917467 @default.
• W2119669929 cites W2007119824 @default.
• W2119669929 cites W2024902576 @default.
• W2119669929 cites W2043066069 @default.
• W2119669929 cites W2048428832 @default.
• W2119669929 cites W2059162919 @default.
• W2119669929 cites W2064508977 @default.
• W2119669929 cites W2128635872 @default.
• W2119669929 cites W2138302361 @default.
• W2119669929 cites W2165436746 @default.
• W2119669929 cites W2244764077 @default.
• W2119669929 cites W2406363927 @default.
• W2119669929 cites W2414723303 @default.
• W2119669929 cites W2415033983 @default.
• W2119669929 cites W2417660769 @default.
• W2119669929 cites W266859766 @default.
• W2119669929 cites W4293247451 @default.
• W2119669929 cites W53629506 @default.
• W2119669929 cites W68935274 @default.
• W2119669929 doi "https://doi.org/10.1073/pnas.95.1.162" @default.
• W2119669929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/18160" @default.
• W2119669929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9419346" @default.
• W2119669929 hasPublicationYear "1998" @default.
• W2119669929 type Work @default.
• W2119669929 sameAs 2119669929 @default.
• W2119669929 citedByCount "57" @default.
• W2119669929 countsByYear W21196699292013 @default.
• W2119669929 countsByYear W21196699292014 @default.
• W2119669929 countsByYear W21196699292015 @default.
• W2119669929 countsByYear W21196699292020 @default.
• W2119669929 countsByYear W21196699292021 @default.
• W2119669929 countsByYear W21196699292022 @default.
• W2119669929 crossrefType "journal-article" @default.
• W2119669929 hasAuthorship W2119669929A5023752321 @default.
• W2119669929 hasAuthorship W2119669929A5024371816 @default.
• W2119669929 hasAuthorship W2119669929A5027363771 @default.
• W2119669929 hasAuthorship W2119669929A5061964017 @default.
• W2119669929 hasAuthorship W2119669929A5065320270 @default.
• W2119669929 hasAuthorship W2119669929A5078159824 @default.
• W2119669929 hasAuthorship W2119669929A5079671192 @default.
• W2119669929 hasAuthorship W2119669929A5082113956 @default.
• W2119669929 hasAuthorship W2119669929A5085264531 @default.
• W2119669929 hasBestOaLocation W21196699291 @default.
• W2119669929 hasConcept C153911025 @default.
• W2119669929 hasConcept C190283241 @default.
• W2119669929 hasConcept C203014093 @default.
• W2119669929 hasConcept C2776364478 @default.
• W2119669929 hasConcept C31573885 @default.
• W2119669929 hasConcept C502942594 @default.
• W2119669929 hasConcept C54355233 @default.
• W2119669929 hasConcept C55493867 @default.
• W2119669929 hasConcept C62112901 @default.
• W2119669929 hasConcept C81885089 @default.
• W2119669929 hasConcept C86803240 @default.
• W2119669929 hasConcept C95444343 @default.
• W2119669929 hasConceptScore W2119669929C153911025 @default.
• W2119669929 hasConceptScore W2119669929C190283241 @default.
• W2119669929 hasConceptScore W2119669929C203014093 @default.
• W2119669929 hasConceptScore W2119669929C2776364478 @default.
• W2119669929 hasConceptScore W2119669929C31573885 @default.
• W2119669929 hasConceptScore W2119669929C502942594 @default.
• W2119669929 hasConceptScore W2119669929C54355233 @default.
• W2119669929 hasConceptScore W2119669929C55493867 @default.
• W2119669929 hasConceptScore W2119669929C62112901 @default.
• W2119669929 hasConceptScore W2119669929C81885089 @default.
• W2119669929 hasConceptScore W2119669929C86803240 @default.
• W2119669929 hasConceptScore W2119669929C95444343 @default.
• W2119669929 hasIssue "1" @default.
• W2119669929 hasLocation W21196699291 @default.
• W2119669929 hasLocation W21196699292 @default.
• W2119669929 hasLocation W21196699293 @default.
• W2119669929 hasLocation W21196699294 @default.
• W2119669929 hasOpenAccess W2119669929 @default.
• W2119669929 hasPrimaryLocation W21196699291 @default.
• W2119669929 hasRelatedWork W1987695408 @default.

• next