Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119682022> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2119682022 endingPage "467" @default.
- W2119682022 startingPage "460" @default.
- W2119682022 abstract "The motor, modulatory, and sensory neurotransmitters that mediate the peristaltic reflex in the mouse colon were identified by direct measurement, and their involvement in various pathways was determined by selective receptor antagonists. Mucosal stimulation in the central compartment of a three-compartment flat sheet preparation of mouse colon elicited ascending contraction and descending relaxation in the orad and caudad compartments, respectively. Ascending contraction was accompanied by substance P release, a marker for excitatory neurotransmitter release, into the orad compartment and was partly inhibited by atropine and spantide, and abolished by a combination of the two antagonists. Descending relaxation was accompanied by vasoactive intestinal peptide (VIP) release, a marker for inhibitory neurotransmitter release, into the caudad compartment, and was partly inhibited by VIP10-28 and NG-nitro-L-arginine, and abolished by a combination of the two agents. Somatostatin release increased during descending relaxation: immunoneutralization of somatostatin or blockade of its effect with a selective somatostatin type 2 receptor antagonist inhibited descending relaxation. The delta-opioid receptor antagonist naltrindole augmented descending relaxation and ascending contraction. Calcitonin gene-related peptide (CGRP) release increased in the central compartment and was mediated by concurrent release of 5-hydroxytryptamine (5-HT) because its release was blocked by a 5-HT4 receptor antagonist. Both the latter and the CGRP antagonist CGRP8-37, inhibited ascending contraction and descending relaxation. Thus, the reflex in mouse like that in rat and human intestine is initiated by mucosal release of 5-HT and activation of 5-HT4 receptors on CGRP sensory neurons and is relayed via somatostatin and opioid interneurons to VIP/nitric-oxide synthase inhibitory motor neurons and via cholinergic interneurons to acetylcholine/tachykinin excitatory motor neurons." @default.
- W2119682022 created "2016-06-24" @default.
- W2119682022 creator A5071470845 @default.
- W2119682022 date "2003-09-09" @default.
- W2119682022 modified "2023-09-25" @default.
- W2119682022 title "Neurotransmitters Mediating the Intestinal Peristaltic Reflex in the Mouse" @default.
- W2119682022 cites W1526437569 @default.
- W2119682022 cites W1898760913 @default.
- W2119682022 cites W1966358418 @default.
- W2119682022 cites W1977474594 @default.
- W2119682022 cites W2010900780 @default.
- W2119682022 cites W2013086524 @default.
- W2119682022 cites W2022138356 @default.
- W2119682022 cites W2023013875 @default.
- W2119682022 cites W2027056640 @default.
- W2119682022 cites W2030899236 @default.
- W2119682022 cites W2044473723 @default.
- W2119682022 cites W2050780404 @default.
- W2119682022 cites W2058278066 @default.
- W2119682022 cites W2094719038 @default.
- W2119682022 cites W2098976206 @default.
- W2119682022 cites W2138958995 @default.
- W2119682022 cites W2148699492 @default.
- W2119682022 cites W2158989951 @default.
- W2119682022 cites W2182586253 @default.
- W2119682022 cites W2410733370 @default.
- W2119682022 cites W2413676558 @default.
- W2119682022 cites W317382823 @default.
- W2119682022 doi "https://doi.org/10.1124/jpet.103.053512" @default.
- W2119682022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12966154" @default.
- W2119682022 hasPublicationYear "2003" @default.
- W2119682022 type Work @default.
- W2119682022 sameAs 2119682022 @default.
- W2119682022 citedByCount "154" @default.
- W2119682022 countsByYear W21196820222012 @default.
- W2119682022 countsByYear W21196820222013 @default.
- W2119682022 countsByYear W21196820222014 @default.
- W2119682022 countsByYear W21196820222015 @default.
- W2119682022 countsByYear W21196820222016 @default.
- W2119682022 countsByYear W21196820222017 @default.
- W2119682022 countsByYear W21196820222018 @default.
- W2119682022 countsByYear W21196820222019 @default.
- W2119682022 countsByYear W21196820222020 @default.
- W2119682022 countsByYear W21196820222021 @default.
- W2119682022 countsByYear W21196820222022 @default.
- W2119682022 countsByYear W21196820222023 @default.
- W2119682022 crossrefType "journal-article" @default.
- W2119682022 hasAuthorship W2119682022A5071470845 @default.
- W2119682022 hasConcept C118303440 @default.
- W2119682022 hasConcept C126322002 @default.
- W2119682022 hasConcept C134018914 @default.
- W2119682022 hasConcept C163170386 @default.
- W2119682022 hasConcept C170493617 @default.
- W2119682022 hasConcept C185592680 @default.
- W2119682022 hasConcept C2776219046 @default.
- W2119682022 hasConcept C2776297358 @default.
- W2119682022 hasConcept C2776885963 @default.
- W2119682022 hasConcept C2777953665 @default.
- W2119682022 hasConcept C2778122271 @default.
- W2119682022 hasConcept C71924100 @default.
- W2119682022 hasConcept C8330315 @default.
- W2119682022 hasConcept C86803240 @default.
- W2119682022 hasConceptScore W2119682022C118303440 @default.
- W2119682022 hasConceptScore W2119682022C126322002 @default.
- W2119682022 hasConceptScore W2119682022C134018914 @default.
- W2119682022 hasConceptScore W2119682022C163170386 @default.
- W2119682022 hasConceptScore W2119682022C170493617 @default.
- W2119682022 hasConceptScore W2119682022C185592680 @default.
- W2119682022 hasConceptScore W2119682022C2776219046 @default.
- W2119682022 hasConceptScore W2119682022C2776297358 @default.
- W2119682022 hasConceptScore W2119682022C2776885963 @default.
- W2119682022 hasConceptScore W2119682022C2777953665 @default.
- W2119682022 hasConceptScore W2119682022C2778122271 @default.
- W2119682022 hasConceptScore W2119682022C71924100 @default.
- W2119682022 hasConceptScore W2119682022C8330315 @default.
- W2119682022 hasConceptScore W2119682022C86803240 @default.
- W2119682022 hasIssue "2" @default.
- W2119682022 hasLocation W21196820221 @default.
- W2119682022 hasLocation W21196820222 @default.
- W2119682022 hasOpenAccess W2119682022 @default.
- W2119682022 hasPrimaryLocation W21196820221 @default.
- W2119682022 hasRelatedWork W1992928536 @default.
- W2119682022 hasRelatedWork W2000223190 @default.
- W2119682022 hasRelatedWork W2003450342 @default.
- W2119682022 hasRelatedWork W2013273018 @default.
- W2119682022 hasRelatedWork W2060795725 @default.
- W2119682022 hasRelatedWork W2067421416 @default.
- W2119682022 hasRelatedWork W2081856271 @default.
- W2119682022 hasRelatedWork W2113887941 @default.
- W2119682022 hasRelatedWork W2153058082 @default.
- W2119682022 hasRelatedWork W2393521223 @default.
- W2119682022 hasVolume "307" @default.
- W2119682022 isParatext "false" @default.
- W2119682022 isRetracted "false" @default.
- W2119682022 magId "2119682022" @default.
- W2119682022 workType "article" @default.