FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119682588> ?p ?o ?g. }

• W2119682588 endingPage "201" @default.
• W2119682588 startingPage "201" @default.
• W2119682588 abstract "To determine, in a cross-sectional evaluation of nondemented individuals, if age-related memory decline is influenced by apolipoprotein E (apoE) genotype.The apoE-4 allele is an important risk factor for AD. PET in cognitively normal apoE-4 carriers (mean age, 56 years) shows reduced cerebral metabolism suggestive of very early AD that precedes clinically evident memory loss or MRI-based hippocampal atrophy.Tests of immediate and delayed recall (primary outcome measures) and other neuropsychological measures (secondary outcome measures) were given to three genetically defined groups of cognitively normal individuals (age, 49 to 69 years) including apoE-4 homozygotes (n = 25), apoE-4 heterozygotes (n = 25, all epsilon3/4), and apoE-4 noncarriers (n = 50). Groups were matched for age, gender, and educational background. Cross-sectional comparisons between the genetic subgroups of the relationship between age and test score were performed for each neuropsychological measure.There were no intergroup differences in mean scores on any neuropsychological measure, but tests sensitive to immediate and delayed recall showed a significant negative correlation with age in the apoE-4 homozygote group relative to the noncarrier group.Consistent with previous neuropsychological studies of early AD, this cross-sectional study suggests that age-related memory decline occurs earlier in cognitively healthy apoE-4 homozygotes than in apoE-4 heterozygotes and noncarriers, and precedes clinically detectable AD." @default.
• W2119682588 created "2016-06-24" @default.
• W2119682588 creator A5013775467 @default.
• W2119682588 creator A5039106156 @default.
• W2119682588 creator A5047768726 @default.
• W2119682588 creator A5047885227 @default.
• W2119682588 creator A5054041565 @default.
• W2119682588 creator A5074086871 @default.
• W2119682588 creator A5090473173 @default.
• W2119682588 creator A5091046259 @default.
• W2119682588 date "1999-07-01" @default.
• W2119682588 modified "2023-09-27" @default.
• W2119682588 title "Preclinical memory decline in cognitively normal apolipoprotein E- 4 homozygotes" @default.
• W2119682588 cites W1989297865 @default.
• W2119682588 cites W1992007228 @default.
• W2119682588 cites W1995006422 @default.
• W2119682588 cites W1996433268 @default.
• W2119682588 cites W1999631936 @default.
• W2119682588 cites W2006603160 @default.
• W2119682588 cites W2009904690 @default.
• W2119682588 cites W2017231145 @default.
• W2119682588 cites W2020411164 @default.
• W2119682588 cites W2024612094 @default.
• W2119682588 cites W2025290060 @default.
• W2119682588 cites W2036362108 @default.
• W2119682588 cites W2039664444 @default.
• W2119682588 cites W2042266730 @default.
• W2119682588 cites W2042410778 @default.
• W2119682588 cites W2081579603 @default.
• W2119682588 cites W2084221243 @default.
• W2119682588 cites W2086363884 @default.
• W2119682588 cites W2099905211 @default.
• W2119682588 cites W2104934386 @default.
• W2119682588 cites W2106900897 @default.
• W2119682588 cites W2107901465 @default.
• W2119682588 cites W2108958131 @default.
• W2119682588 cites W2111709425 @default.
• W2119682588 cites W2111774300 @default.
• W2119682588 cites W2126974689 @default.
• W2119682588 cites W2156220037 @default.
• W2119682588 cites W2232548624 @default.
• W2119682588 doi "https://doi.org/10.1212/wnl.53.1.201" @default.
• W2119682588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10408560" @default.
• W2119682588 hasPublicationYear "1999" @default.
• W2119682588 type Work @default.
• W2119682588 sameAs 2119682588 @default.
• W2119682588 citedByCount "117" @default.
• W2119682588 countsByYear W21196825882012 @default.
• W2119682588 countsByYear W21196825882013 @default.
• W2119682588 countsByYear W21196825882014 @default.
• W2119682588 countsByYear W21196825882015 @default.
• W2119682588 countsByYear W21196825882016 @default.
• W2119682588 countsByYear W21196825882017 @default.
• W2119682588 countsByYear W21196825882018 @default.
• W2119682588 countsByYear W21196825882019 @default.
• W2119682588 countsByYear W21196825882020 @default.
• W2119682588 countsByYear W21196825882021 @default.
• W2119682588 countsByYear W21196825882022 @default.
• W2119682588 countsByYear W21196825882023 @default.
• W2119682588 crossrefType "journal-article" @default.
• W2119682588 hasAuthorship W2119682588A5013775467 @default.
• W2119682588 hasAuthorship W2119682588A5039106156 @default.
• W2119682588 hasAuthorship W2119682588A5047768726 @default.
• W2119682588 hasAuthorship W2119682588A5047885227 @default.
• W2119682588 hasAuthorship W2119682588A5054041565 @default.
• W2119682588 hasAuthorship W2119682588A5074086871 @default.
• W2119682588 hasAuthorship W2119682588A5090473173 @default.
• W2119682588 hasAuthorship W2119682588A5091046259 @default.
• W2119682588 hasConcept C100660578 @default.
• W2119682588 hasConcept C104317684 @default.
• W2119682588 hasConcept C118552586 @default.
• W2119682588 hasConcept C126322002 @default.
• W2119682588 hasConcept C14216870 @default.
• W2119682588 hasConcept C15744967 @default.
• W2119682588 hasConcept C169900460 @default.
• W2119682588 hasConcept C180747234 @default.
• W2119682588 hasConcept C180754005 @default.
• W2119682588 hasConcept C2776811091 @default.
• W2119682588 hasConcept C2779134260 @default.
• W2119682588 hasConcept C2779483572 @default.
• W2119682588 hasConcept C2984863031 @default.
• W2119682588 hasConcept C54355233 @default.
• W2119682588 hasConcept C57089818 @default.
• W2119682588 hasConcept C71924100 @default.
• W2119682588 hasConcept C86803240 @default.
• W2119682588 hasConceptScore W2119682588C100660578 @default.
• W2119682588 hasConceptScore W2119682588C104317684 @default.
• W2119682588 hasConceptScore W2119682588C118552586 @default.
• W2119682588 hasConceptScore W2119682588C126322002 @default.
• W2119682588 hasConceptScore W2119682588C14216870 @default.
• W2119682588 hasConceptScore W2119682588C15744967 @default.
• W2119682588 hasConceptScore W2119682588C169900460 @default.
• W2119682588 hasConceptScore W2119682588C180747234 @default.
• W2119682588 hasConceptScore W2119682588C180754005 @default.
• W2119682588 hasConceptScore W2119682588C2776811091 @default.
• W2119682588 hasConceptScore W2119682588C2779134260 @default.
• W2119682588 hasConceptScore W2119682588C2779483572 @default.
• W2119682588 hasConceptScore W2119682588C2984863031 @default.

• next