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- W2119700184 abstract "Amphotericin B therapy is hampered by numerous adverse effects but remains the treatment of choice for disseminated fungal infections. A new form of amphotericin B delivery, which utilizes liposome vesicles, is currently under investigation. Preliminary evidence suggests that liposome-encapsulated amphotericin B has a wider therapeutic index than free amphotericin B and allows for the use of larger total doses. The mechanism of reduced toxicity and enhanced activity may be associated with a liposome donor effect, an erythrocyte protective effect, and a liposome-targeting ability. Liposome-encapsulated amphotericin B tends to be entrapped or taken up by organs rich in reticuloendothelial cells--a particular advantage since disseminated fungal infections localize in these areas. This liposome-encapsulated preparation appears to represent a promising new form of antifungal therapy that may reduce the dose-limiting toxicities of amphotericin B and improve treatment response." @default.
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- W2119700184 date "1988-11-01" @default.
- W2119700184 modified "2023-09-23" @default.
- W2119700184 title "Liposome-Encapsulated Amphotericin B: A Promising New Treatment for Disseminated Fungal Infections" @default.
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- W2119700184 doi "https://doi.org/10.1093/clinids/10.6.1097" @default.
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