FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119713108> ?p ?o ?g. }

• W2119713108 endingPage "E701" @default.
• W2119713108 startingPage "E690" @default.
• W2119713108 abstract "There are strong links between obesity, elevated free fatty acids, and type 2 diabetes. Specifically, the saturated fatty acid palmitate has pleiotropic effects on β-cell function and survival. In the present study, we sought to determine the mechanism by which palmitate affects intracellular Ca 2+ , and in particular the role of the endoplasmic reticulum (ER). In human β-cells and MIN6 cells, palmitate rapidly increased cytosolic Ca 2+ through a combination of Ca 2+ store release and extracellular Ca 2+ influx. Palmitate caused a reversible lowering of ER Ca 2+ , measured directly with the fluorescent protein-based ER Ca 2+ sensor D1ER. Using another genetically encoded indicator, we observed long-lasting oscillations of cytosolic Ca 2+ in palmitate-treated cells. In keeping with this observed ER Ca 2+ depletion, palmitate induced rapid phosphorylation of the ER Ca 2+ sensor protein kinase R-like ER kinase (PERK) and subsequently ER stress and β-cell death. We detected little palmitate-induced insulin secretion, suggesting that these Ca 2+ signals are poorly coupled to exocytosis. In summary, we have characterized Ca 2+ -dependent mechanisms involved in altered β-cell function and survival induced by the free fatty acid palmitate. We present the first direct evidence that free fatty acids reduce ER Ca 2+ and shed light on pathways involved in lipotoxicity and the pathogenesis of type 2 diabetes." @default.
• W2119713108 created "2016-06-24" @default.
• W2119713108 creator A5010661210 @default.
• W2119713108 creator A5018499087 @default.
• W2119713108 creator A5065636025 @default.
• W2119713108 creator A5088834028 @default.
• W2119713108 date "2009-04-01" @default.
• W2119713108 modified "2023-10-15" @default.
• W2119713108 title "Effects of palmitate on ER and cytosolic Ca²⁺homeostasis in β-cells" @default.
• W2119713108 cites W1826492881 @default.
• W2119713108 cites W1843919112 @default.
• W2119713108 cites W1851126014 @default.
• W2119713108 cites W1964914253 @default.
• W2119713108 cites W1966467373 @default.
• W2119713108 cites W1967307466 @default.
• W2119713108 cites W1967626349 @default.
• W2119713108 cites W1967659527 @default.
• W2119713108 cites W1970303002 @default.
• W2119713108 cites W1970420856 @default.
• W2119713108 cites W1971639453 @default.
• W2119713108 cites W2002056541 @default.
• W2119713108 cites W2005754586 @default.
• W2119713108 cites W2007078899 @default.
• W2119713108 cites W2015143141 @default.
• W2119713108 cites W2019925176 @default.
• W2119713108 cites W2020098267 @default.
• W2119713108 cites W2020468088 @default.
• W2119713108 cites W2027197889 @default.
• W2119713108 cites W2028279084 @default.
• W2119713108 cites W2030903086 @default.
• W2119713108 cites W2036848107 @default.
• W2119713108 cites W2041888630 @default.
• W2119713108 cites W2052311839 @default.
• W2119713108 cites W2052347872 @default.
• W2119713108 cites W2053984056 @default.
• W2119713108 cites W2054333415 @default.
• W2119713108 cites W2057692152 @default.
• W2119713108 cites W2068034774 @default.
• W2119713108 cites W2074549465 @default.
• W2119713108 cites W2077032611 @default.
• W2119713108 cites W2080483538 @default.
• W2119713108 cites W2081368176 @default.
• W2119713108 cites W2084862721 @default.
• W2119713108 cites W2086482350 @default.
• W2119713108 cites W2089894176 @default.
• W2119713108 cites W2092835169 @default.
• W2119713108 cites W2093021792 @default.
• W2119713108 cites W2094306529 @default.
• W2119713108 cites W2095226510 @default.
• W2119713108 cites W2096273239 @default.
• W2119713108 cites W2102964449 @default.
• W2119713108 cites W2103637713 @default.
• W2119713108 cites W2105497606 @default.
• W2119713108 cites W2108709856 @default.
• W2119713108 cites W2112115574 @default.
• W2119713108 cites W2112286580 @default.
• W2119713108 cites W2113544353 @default.
• W2119713108 cites W2120653342 @default.
• W2119713108 cites W2125871871 @default.
• W2119713108 cites W2126610675 @default.
• W2119713108 cites W2127825630 @default.
• W2119713108 cites W2128326754 @default.
• W2119713108 cites W2128473384 @default.
• W2119713108 cites W2135805245 @default.
• W2119713108 cites W2141063928 @default.
• W2119713108 cites W2145869245 @default.
• W2119713108 cites W2153535707 @default.
• W2119713108 cites W2153696453 @default.
• W2119713108 cites W2157894448 @default.
• W2119713108 cites W2158554737 @default.
• W2119713108 cites W2162664501 @default.
• W2119713108 cites W2162918952 @default.
• W2119713108 cites W2163216300 @default.
• W2119713108 cites W2165064047 @default.
• W2119713108 cites W4230095346 @default.
• W2119713108 doi "https://doi.org/10.1152/ajpendo.90525.2008" @default.
• W2119713108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19141690" @default.
• W2119713108 hasPublicationYear "2009" @default.
• W2119713108 type Work @default.
• W2119713108 sameAs 2119713108 @default.
• W2119713108 citedByCount "175" @default.
• W2119713108 countsByYear W21197131082012 @default.
• W2119713108 countsByYear W21197131082013 @default.
• W2119713108 countsByYear W21197131082014 @default.
• W2119713108 countsByYear W21197131082015 @default.
• W2119713108 countsByYear W21197131082016 @default.
• W2119713108 countsByYear W21197131082017 @default.
• W2119713108 countsByYear W21197131082018 @default.
• W2119713108 countsByYear W21197131082019 @default.
• W2119713108 countsByYear W21197131082020 @default.
• W2119713108 countsByYear W21197131082021 @default.
• W2119713108 countsByYear W21197131082022 @default.
• W2119713108 countsByYear W21197131082023 @default.
• W2119713108 crossrefType "journal-article" @default.
• W2119713108 hasAuthorship W2119713108A5010661210 @default.
• W2119713108 hasAuthorship W2119713108A5018499087 @default.
• W2119713108 hasAuthorship W2119713108A5065636025 @default.
• W2119713108 hasAuthorship W2119713108A5088834028 @default.

• next