FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119723730> ?p ?o ?g. }

• W2119723730 endingPage "314" @default.
• W2119723730 startingPage "309" @default.
• W2119723730 abstract "Brain tumors almost universally have fatal outcomes; new therapeutics are desperately needed and will only come from improved understandins of glioma biology.Exosomes are endosomally derived 30~100 nm membranous vesicles released from many cell types. Examples from GL26 cells were here purified using density gradient ultracentrifugation and monitored for effects on GL26 tumor growth in C57BL/6j mice (H-2b). Lactate dehydrogenase release assays were used to detect the cytotoxic activity of CD8+T and NK cells. Percentages of immune cells producing intracellular cytokines were analyzed by FACS.In this study, exosomes from murine-derived GL26 cells significantly promoted in vivo tumor growth in GL26-bearing B6 mice. Then we further analyzed the effects of the GL26 cells-derived exosomes on immune cells including CD8+T, CD4+T and NK cells. Inhibition of CD8+T cell cytotoxic activity was demonstrated by CD8+T cell depletion assays in vivo and LDH release assays in vitro. The treatment of mice with exosomes also led to a reduction in the percentages of CD8+T cells in splenocytes as determined by FACS analysis. Key features of CD8+T cell activity were inhibited, including release of IFN-gamma and granzyme B. There were no effects of exosomes on CD4+T cells and NK cells.Based on our data, for the first time we demonstrated that exosomes from murine derived GL26 cells promote the tumor growth by inhibition of CD8+T cells in vivo and thus may be a potential therapeutic target." @default.
• W2119723730 created "2016-06-24" @default.
• W2119723730 creator A5052769199 @default.
• W2119723730 creator A5054484090 @default.
• W2119723730 creator A5077458638 @default.
• W2119723730 date "2013-01-31" @default.
• W2119723730 modified "2023-09-23" @default.
• W2119723730 title "Exosomes from Murine-derived GL26 Cells Promote Glioblastoma Tumor Growth by Reducing Number and Function of CD8+T Cells" @default.
• W2119723730 cites W1598843567 @default.
• W2119723730 cites W1904412191 @default.
• W2119723730 cites W1945775323 @default.
• W2119723730 cites W1976952519 @default.
• W2119723730 cites W1985540981 @default.
• W2119723730 cites W1991198008 @default.
• W2119723730 cites W1996354576 @default.
• W2119723730 cites W1996398553 @default.
• W2119723730 cites W1996877529 @default.
• W2119723730 cites W2015601897 @default.
• W2119723730 cites W2036109237 @default.
• W2119723730 cites W2042751187 @default.
• W2119723730 cites W2045792615 @default.
• W2119723730 cites W2048883725 @default.
• W2119723730 cites W2060625207 @default.
• W2119723730 cites W2082386398 @default.
• W2119723730 cites W2087025867 @default.
• W2119723730 cites W2097514147 @default.
• W2119723730 cites W2103872250 @default.
• W2119723730 cites W2106175063 @default.
• W2119723730 cites W2116291089 @default.
• W2119723730 cites W2124104087 @default.
• W2119723730 cites W2125066454 @default.
• W2119723730 cites W2146470803 @default.
• W2119723730 cites W2153092839 @default.
• W2119723730 cites W2156106286 @default.
• W2119723730 cites W2159312193 @default.
• W2119723730 cites W2160328215 @default.
• W2119723730 cites W2165957370 @default.
• W2119723730 cites W2166370041 @default.
• W2119723730 cites W2281508338 @default.
• W2119723730 cites W2993894574 @default.
• W2119723730 doi "https://doi.org/10.7314/apjcp.2013.14.1.309" @default.
• W2119723730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23534743" @default.
• W2119723730 hasPublicationYear "2013" @default.
• W2119723730 type Work @default.
• W2119723730 sameAs 2119723730 @default.
• W2119723730 citedByCount "48" @default.
• W2119723730 countsByYear W21197237302014 @default.
• W2119723730 countsByYear W21197237302015 @default.
• W2119723730 countsByYear W21197237302016 @default.
• W2119723730 countsByYear W21197237302017 @default.
• W2119723730 countsByYear W21197237302018 @default.
• W2119723730 countsByYear W21197237302019 @default.
• W2119723730 countsByYear W21197237302020 @default.
• W2119723730 countsByYear W21197237302021 @default.
• W2119723730 countsByYear W21197237302022 @default.
• W2119723730 countsByYear W21197237302023 @default.
• W2119723730 crossrefType "journal-article" @default.
• W2119723730 hasAuthorship W2119723730A5052769199 @default.
• W2119723730 hasAuthorship W2119723730A5054484090 @default.
• W2119723730 hasAuthorship W2119723730A5077458638 @default.
• W2119723730 hasBestOaLocation W21197237301 @default.
• W2119723730 hasConcept C104317684 @default.
• W2119723730 hasConcept C129374314 @default.
• W2119723730 hasConcept C145059251 @default.
• W2119723730 hasConcept C149532602 @default.
• W2119723730 hasConcept C150903083 @default.
• W2119723730 hasConcept C153911025 @default.
• W2119723730 hasConcept C154317977 @default.
• W2119723730 hasConcept C167672396 @default.
• W2119723730 hasConcept C185592680 @default.
• W2119723730 hasConcept C202751555 @default.
• W2119723730 hasConcept C203014093 @default.
• W2119723730 hasConcept C20518536 @default.
• W2119723730 hasConcept C207001950 @default.
• W2119723730 hasConcept C2776090121 @default.
• W2119723730 hasConcept C2780380082 @default.
• W2119723730 hasConcept C502942594 @default.
• W2119723730 hasConcept C55493867 @default.
• W2119723730 hasConcept C86803240 @default.
• W2119723730 hasConcept C8891405 @default.
• W2119723730 hasConcept C95444343 @default.
• W2119723730 hasConceptScore W2119723730C104317684 @default.
• W2119723730 hasConceptScore W2119723730C129374314 @default.
• W2119723730 hasConceptScore W2119723730C145059251 @default.
• W2119723730 hasConceptScore W2119723730C149532602 @default.
• W2119723730 hasConceptScore W2119723730C150903083 @default.
• W2119723730 hasConceptScore W2119723730C153911025 @default.
• W2119723730 hasConceptScore W2119723730C154317977 @default.
• W2119723730 hasConceptScore W2119723730C167672396 @default.
• W2119723730 hasConceptScore W2119723730C185592680 @default.
• W2119723730 hasConceptScore W2119723730C202751555 @default.
• W2119723730 hasConceptScore W2119723730C203014093 @default.
• W2119723730 hasConceptScore W2119723730C20518536 @default.
• W2119723730 hasConceptScore W2119723730C207001950 @default.
• W2119723730 hasConceptScore W2119723730C2776090121 @default.
• W2119723730 hasConceptScore W2119723730C2780380082 @default.
• W2119723730 hasConceptScore W2119723730C502942594 @default.
• W2119723730 hasConceptScore W2119723730C55493867 @default.

• next