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• W2119723863 abstract "Animal models of human diseases are essentially required to investigate the pathophysiological mechanisms of the diseases, and to test potential therapies for the clinics. However, neurodegenerative diseases including Parkinson’s disease (PD) are particularly difficult to model or to recapitulate the features because most of them have multifactorial etiologies and chronically progressive symptoms, although Huntington’s disease (HD) has an identified etiology such as an excessive expansion of CAG repeats. In this review, PD and HD which were typical neurodegenerative diseases were studied. The animals of PD were roughly classified into a neurotoxic model and a genetic model, and those of HD were divided into excitotoxic, transgenic, knock-in, and knock-out models. Insights obtained from these animal models of neurodegenerative diseases will guide us toward the understanding of the disease mechanisms, the design of new therapeutic strategies, and finally translation into the clinics. (Brain & NeuroRehabilitation 2011; 4: 30-34)" @default.
• W2119723863 created "2016-06-24" @default.
• W2119723863 creator A5073657262 @default.
• W2119723863 date "2011-01-01" @default.
• W2119723863 modified "2023-09-25" @default.
• W2119723863 title "Animal Models of Neurodegenerative Diseases" @default.
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• W2119723863 doi "https://doi.org/10.12786/bn.2011.4.1.30" @default.
• W2119723863 hasPublicationYear "2011" @default.
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