Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119725082> ?p ?o ?g. }
- W2119725082 endingPage "420" @default.
- W2119725082 startingPage "411" @default.
- W2119725082 abstract "During the last 20 years, our understanding of the mechanisms underlying Alzheimer’s disease (AD) has considerably improved, in part owing to both in vitro and in vivo model systems. Studies in mice expressing both human amyloid precursor protein and human tau have provided clear evidence that amyloid-β and tau interact in the pathogenesis of AD. Moreover, amyloid-β toxicity has been shown to be tau-dependent since reducing tau levels prevents behavioral deficits and sudden death in amyloid precursor protein transgenic mice. As tau pathology preferentially develops in specific sites and spreads in a predictable manner across the brain, understanding the mechanism underlying tau dysfunction should be a focus in AD mouse modeling. A defined effort must be made to develop therapies that directly address the impact of tau dysfunction in the pathogenesis of AD. Finally, early diagnosis of AD is essential and this must be made possible by identification of early biomarkers, behavioral changes or use of novel imaging techniques." @default.
- W2119725082 created "2016-06-24" @default.
- W2119725082 creator A5001609822 @default.
- W2119725082 creator A5013804286 @default.
- W2119725082 date "2010-05-01" @default.
- W2119725082 modified "2023-09-29" @default.
- W2119725082 title "Amyloid precursor protein and tau transgenic models of Alzheimer’s disease: insights from the past and directions for the future" @default.
- W2119725082 cites W1480786153 @default.
- W2119725082 cites W1511517753 @default.
- W2119725082 cites W1522789528 @default.
- W2119725082 cites W1528219518 @default.
- W2119725082 cites W1534001036 @default.
- W2119725082 cites W1584834830 @default.
- W2119725082 cites W1655404681 @default.
- W2119725082 cites W1940862436 @default.
- W2119725082 cites W1963568158 @default.
- W2119725082 cites W1965275873 @default.
- W2119725082 cites W1965709917 @default.
- W2119725082 cites W1966614543 @default.
- W2119725082 cites W1967061503 @default.
- W2119725082 cites W1967287827 @default.
- W2119725082 cites W1967464880 @default.
- W2119725082 cites W1968937229 @default.
- W2119725082 cites W1971744915 @default.
- W2119725082 cites W1972747973 @default.
- W2119725082 cites W1974760231 @default.
- W2119725082 cites W1983670592 @default.
- W2119725082 cites W1984320700 @default.
- W2119725082 cites W1991993391 @default.
- W2119725082 cites W1995344309 @default.
- W2119725082 cites W1995515835 @default.
- W2119725082 cites W1999631936 @default.
- W2119725082 cites W2001210466 @default.
- W2119725082 cites W2004538934 @default.
- W2119725082 cites W2005681172 @default.
- W2119725082 cites W2005873882 @default.
- W2119725082 cites W2010240177 @default.
- W2119725082 cites W2010925911 @default.
- W2119725082 cites W2012901990 @default.
- W2119725082 cites W2016390889 @default.
- W2119725082 cites W2016758992 @default.
- W2119725082 cites W2016811754 @default.
- W2119725082 cites W2018908557 @default.
- W2119725082 cites W2022816408 @default.
- W2119725082 cites W2024559246 @default.
- W2119725082 cites W2025561374 @default.
- W2119725082 cites W2034286717 @default.
- W2119725082 cites W2035156043 @default.
- W2119725082 cites W2036288989 @default.
- W2119725082 cites W2036362108 @default.
- W2119725082 cites W2039069312 @default.
- W2119725082 cites W2043618425 @default.
- W2119725082 cites W2046781319 @default.
- W2119725082 cites W2047240821 @default.
- W2119725082 cites W2048111211 @default.
- W2119725082 cites W2048139403 @default.
- W2119725082 cites W2052742260 @default.
- W2119725082 cites W2053535174 @default.
- W2119725082 cites W2057249855 @default.
- W2119725082 cites W2058723245 @default.
- W2119725082 cites W2062214806 @default.
- W2119725082 cites W2067267086 @default.
- W2119725082 cites W2067998641 @default.
- W2119725082 cites W2076482846 @default.
- W2119725082 cites W2084453905 @default.
- W2119725082 cites W2088341376 @default.
- W2119725082 cites W2088384294 @default.
- W2119725082 cites W2089331767 @default.
- W2119725082 cites W2095745901 @default.
- W2119725082 cites W2096410114 @default.
- W2119725082 cites W2096665275 @default.
- W2119725082 cites W2099340107 @default.
- W2119725082 cites W2105704879 @default.
- W2119725082 cites W2106919606 @default.
- W2119725082 cites W2110054485 @default.
- W2119725082 cites W2110888808 @default.
- W2119725082 cites W2118694086 @default.
- W2119725082 cites W2126800086 @default.
- W2119725082 cites W2129932730 @default.
- W2119725082 cites W2130723719 @default.
- W2119725082 cites W2133659563 @default.
- W2119725082 cites W2135309154 @default.
- W2119725082 cites W2135640564 @default.
- W2119725082 cites W2135661040 @default.
- W2119725082 cites W2141839336 @default.
- W2119725082 cites W2152446053 @default.
- W2119725082 cites W2153273744 @default.
- W2119725082 cites W2159237576 @default.
- W2119725082 cites W2163301650 @default.
- W2119725082 cites W2165725890 @default.
- W2119725082 cites W2166736363 @default.
- W2119725082 cites W2167064901 @default.
- W2119725082 cites W2168334242 @default.
- W2119725082 cites W2169152986 @default.
- W2119725082 cites W2169473035 @default.
- W2119725082 cites W2170725855 @default.
- W2119725082 cites W2171530504 @default.
- W2119725082 cites W2172007938 @default.