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• W2119735087 abstract "Abstract The specific role of ON and OFF retinal information channels in the generation of the horizontal optokinetic nystagmus (OKN) of the frog was studied. Coil recordings of monocular eye and head OKN were obtained before and after intravitreal injection of two drugs that block either ON or OFF channels. The intravitreal injection of 2-amino-4-phosphonobutyrate (APB), a glutamate analog that selectively blocks the ON retinal channel, strongly reduced or even cancelled the monocular OKN of the head and of the eye. The intravitreal injection of another glutamate analog, the cis-2, 3-piperidine dicarboxylic acid (PDA) that especially blocks the OFF retinal channel, did not affect the gain velocity of the slow phase of both the horizontal monocular head and eye OKN, for low stimulus velocities. Our results suggest that the retinal ON information channel, but not the OFF channel, is involved in the generation of the slow phase of the OKN of the frog, at least at low drum velocities." @default.
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• W2119735087 date "1989-04-01" @default.
• W2119735087 modified "2023-10-14" @default.
• W2119735087 title "Involvement of ON and OFF retinal channels in the eye and head horizontal optokinetic nystagmus of the frog" @default.
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• W2119735087 doi "https://doi.org/10.1017/s0952523800002169" @default.
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