FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119749069> ?p ?o ?g. }

• W2119749069 endingPage "326" @default.
• W2119749069 startingPage "317" @default.
• W2119749069 abstract "Renal expression of the peptide hormone urotensin II (UII) and its receptor (UTR) are dependent on kidney maturation and anatomical regions. However, renal regional hemodynamic effects of UII in neonates are unclear. Here, we investigated regional hemodynamic responses to acute intrarenal arterial administration of UII in newborn pigs. Western immunoblotting and immunofluorescence confirmed UTR expression and membrane localization in newborn pig renal afferent arterioles and afferent arteriolar smooth muscle cells respectively. Intrarenal arterial bolus injections of human UII (hUII; 1-100 ng/kg) resulted in a dose-dependent decrease in total renal blood flow (RBF) and an increase in mean arterial pressure (MAP) and renal vascular resistance (RVR) in newborn pigs. Moreover, hUII dose dependently reduced cortical blood flow (CBF) but increased medullary blood flow (MBF) in the piglets. hUII-induced MAP elevation and hemodynamic changes were inhibited by urantide, a UTR antagonist, but not losartan, a type 1 angiotensin II receptor antagonist. U-73122, a phospholipase C (PLC) inhibitor, and 2-aminoethoxydiphenyl borate, an inositol 1,4,5 trisphosphate (IP₃) receptor antagonist, attenuated hUII-induced MAP and RVR elevations, RBF and CBF reductions, but not MBF increase. These findings indicate that intrarenal arterial administration of hUII elevates blood pressure and induces region-selective renal hemodynamic changes in newborn pigs. Our data also suggest that the PLC/IP₃ signaling pathway contributes to hUII-induced alterations in MAP, RBF, RVR, and CBF but not MBF in newborn pigs." @default.
• W2119749069 created "2016-06-24" @default.
• W2119749069 creator A5016851807 @default.
• W2119749069 creator A5089800747 @default.
• W2119749069 date "2013-04-03" @default.
• W2119749069 modified "2023-10-17" @default.
• W2119749069 title "Pressor and renal regional hemodynamic effects of urotensin II in neonatal pigs" @default.
• W2119749069 cites W1970425755 @default.
• W2119749069 cites W1973273007 @default.
• W2119749069 cites W1974252618 @default.
• W2119749069 cites W1975972629 @default.
• W2119749069 cites W1978079833 @default.
• W2119749069 cites W1980166477 @default.
• W2119749069 cites W1984764772 @default.
• W2119749069 cites W1990334947 @default.
• W2119749069 cites W1993518928 @default.
• W2119749069 cites W1993580852 @default.
• W2119749069 cites W2001063121 @default.
• W2119749069 cites W2012564036 @default.
• W2119749069 cites W2020075835 @default.
• W2119749069 cites W2020466261 @default.
• W2119749069 cites W2025319034 @default.
• W2119749069 cites W2025748990 @default.
• W2119749069 cites W2048101110 @default.
• W2119749069 cites W2049784193 @default.
• W2119749069 cites W2056735945 @default.
• W2119749069 cites W2062779147 @default.
• W2119749069 cites W2065693868 @default.
• W2119749069 cites W2071726718 @default.
• W2119749069 cites W2082277504 @default.
• W2119749069 cites W2085855801 @default.
• W2119749069 cites W2088868787 @default.
• W2119749069 cites W2089065535 @default.
• W2119749069 cites W2089781939 @default.
• W2119749069 cites W2091968858 @default.
• W2119749069 cites W2092357572 @default.
• W2119749069 cites W2097017288 @default.
• W2119749069 cites W2114581064 @default.
• W2119749069 cites W2117226055 @default.
• W2119749069 cites W2118438418 @default.
• W2119749069 cites W2123269174 @default.
• W2119749069 cites W2130943352 @default.
• W2119749069 cites W2134346060 @default.
• W2119749069 cites W2135697313 @default.
• W2119749069 cites W2138443098 @default.
• W2119749069 cites W2139967491 @default.
• W2119749069 cites W2140530698 @default.
• W2119749069 cites W2141335461 @default.
• W2119749069 cites W2144950012 @default.
• W2119749069 cites W2145869779 @default.
• W2119749069 cites W2152996717 @default.
• W2119749069 cites W2157352021 @default.
• W2119749069 cites W2157815513 @default.
• W2119749069 cites W2162679716 @default.
• W2119749069 cites W2167960364 @default.
• W2119749069 cites W2281229447 @default.
• W2119749069 cites W2317147441 @default.
• W2119749069 doi "https://doi.org/10.1530/joe-12-0556" @default.
• W2119749069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23554507" @default.
• W2119749069 hasPublicationYear "2013" @default.
• W2119749069 type Work @default.
• W2119749069 sameAs 2119749069 @default.
• W2119749069 citedByCount "9" @default.
• W2119749069 countsByYear W21197490692013 @default.
• W2119749069 countsByYear W21197490692014 @default.
• W2119749069 countsByYear W21197490692016 @default.
• W2119749069 countsByYear W21197490692017 @default.
• W2119749069 countsByYear W21197490692019 @default.
• W2119749069 countsByYear W21197490692022 @default.
• W2119749069 countsByYear W21197490692023 @default.
• W2119749069 crossrefType "journal-article" @default.
• W2119749069 hasAuthorship W2119749069A5016851807 @default.
• W2119749069 hasAuthorship W2119749069A5089800747 @default.
• W2119749069 hasBestOaLocation W21197490691 @default.
• W2119749069 hasConcept C126322002 @default.
• W2119749069 hasConcept C134018914 @default.
• W2119749069 hasConcept C142225936 @default.
• W2119749069 hasConcept C170493617 @default.
• W2119749069 hasConcept C178853913 @default.
• W2119749069 hasConcept C2776452961 @default.
• W2119749069 hasConcept C2777953023 @default.
• W2119749069 hasConcept C2779935178 @default.
• W2119749069 hasConcept C2780091579 @default.
• W2119749069 hasConcept C2780288358 @default.
• W2119749069 hasConcept C2781073237 @default.
• W2119749069 hasConcept C2908929049 @default.
• W2119749069 hasConcept C71924100 @default.
• W2119749069 hasConcept C84393581 @default.
• W2119749069 hasConcept C86803240 @default.
• W2119749069 hasConceptScore W2119749069C126322002 @default.
• W2119749069 hasConceptScore W2119749069C134018914 @default.
• W2119749069 hasConceptScore W2119749069C142225936 @default.
• W2119749069 hasConceptScore W2119749069C170493617 @default.
• W2119749069 hasConceptScore W2119749069C178853913 @default.
• W2119749069 hasConceptScore W2119749069C2776452961 @default.
• W2119749069 hasConceptScore W2119749069C2777953023 @default.
• W2119749069 hasConceptScore W2119749069C2779935178 @default.
• W2119749069 hasConceptScore W2119749069C2780091579 @default.

• next