Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119751640> ?p ?o ?g. }
- W2119751640 abstract "Although severe idiosyncratic drug-induced liver injury (DILI) is a rare event, it has a large impact on the fate of affected patients and the incriminated drug. Hepatic metabolism of drugs, which occurs in the generation of chemically reactive metabolites in critical amounts, seems to underlie most instances of DILI. Genetic polymorphisms in activating and detoxifying enzymes determine, in part, the extent of cellular stress. A cascade of events, where the pathogenetic relevance of single steps is likely to vary from drug to drug, leads to the disturbance of cellular homeostasis, to mitochondrial dysfunction, to the activation of cell death promoting pathways and the release of drug-modified macromolecules and/or danger signals that initiate an innate and/or adaptive immune response. The patient's response to the initial drug-induced cellular dysfunction determines whether adaptation to the drug-induced cellular stress or DILI in one of its many forms of clinical presentation occurs. Although risk factors for developing DILI have been identified and many pathogenetic mechanisms have been elucidated in model systems, idiosyncratic drug reactions remain unpredictable." @default.
- W2119751640 created "2016-06-24" @default.
- W2119751640 creator A5009952675 @default.
- W2119751640 creator A5080569684 @default.
- W2119751640 creator A5086832629 @default.
- W2119751640 date "2010-09-24" @default.
- W2119751640 modified "2023-09-26" @default.
- W2119751640 title "Liver injury caused by drugs: an update" @default.
- W2119751640 cites W1482264334 @default.
- W2119751640 cites W154273085 @default.
- W2119751640 cites W1963784839 @default.
- W2119751640 cites W1966268750 @default.
- W2119751640 cites W1967734409 @default.
- W2119751640 cites W1969780974 @default.
- W2119751640 cites W1970468480 @default.
- W2119751640 cites W1975440270 @default.
- W2119751640 cites W1979437648 @default.
- W2119751640 cites W1979893692 @default.
- W2119751640 cites W1982561289 @default.
- W2119751640 cites W1983598515 @default.
- W2119751640 cites W1985400979 @default.
- W2119751640 cites W1991417155 @default.
- W2119751640 cites W1992543987 @default.
- W2119751640 cites W1994235174 @default.
- W2119751640 cites W1996627962 @default.
- W2119751640 cites W1996684430 @default.
- W2119751640 cites W1997037955 @default.
- W2119751640 cites W1998048643 @default.
- W2119751640 cites W1998416434 @default.
- W2119751640 cites W1998618215 @default.
- W2119751640 cites W2000837493 @default.
- W2119751640 cites W2001689124 @default.
- W2119751640 cites W2003268732 @default.
- W2119751640 cites W2003856834 @default.
- W2119751640 cites W2004615056 @default.
- W2119751640 cites W2009648599 @default.
- W2119751640 cites W2017946433 @default.
- W2119751640 cites W2018070308 @default.
- W2119751640 cites W2020218381 @default.
- W2119751640 cites W2020976497 @default.
- W2119751640 cites W2025456566 @default.
- W2119751640 cites W2028992331 @default.
- W2119751640 cites W2031364396 @default.
- W2119751640 cites W2032322593 @default.
- W2119751640 cites W2032443752 @default.
- W2119751640 cites W2035709322 @default.
- W2119751640 cites W2036752080 @default.
- W2119751640 cites W2039895358 @default.
- W2119751640 cites W2040528293 @default.
- W2119751640 cites W2045335969 @default.
- W2119751640 cites W2047087938 @default.
- W2119751640 cites W2052941877 @default.
- W2119751640 cites W2053449731 @default.
- W2119751640 cites W2053997785 @default.
- W2119751640 cites W2055128986 @default.
- W2119751640 cites W2057657462 @default.
- W2119751640 cites W2060470911 @default.
- W2119751640 cites W2064599614 @default.
- W2119751640 cites W2069830104 @default.
- W2119751640 cites W2073725977 @default.
- W2119751640 cites W2074213282 @default.
- W2119751640 cites W2080211164 @default.
- W2119751640 cites W2085402052 @default.
- W2119751640 cites W2087598382 @default.
- W2119751640 cites W2089707005 @default.
- W2119751640 cites W2092375748 @default.
- W2119751640 cites W2095134596 @default.
- W2119751640 cites W2097535345 @default.
- W2119751640 cites W2097901599 @default.
- W2119751640 cites W2099753110 @default.
- W2119751640 cites W2099922198 @default.
- W2119751640 cites W2101893734 @default.
- W2119751640 cites W2107947237 @default.
- W2119751640 cites W2110440434 @default.
- W2119751640 cites W2112182958 @default.
- W2119751640 cites W2115540154 @default.
- W2119751640 cites W2122878868 @default.
- W2119751640 cites W2124012426 @default.
- W2119751640 cites W2135302201 @default.
- W2119751640 cites W2137577984 @default.
- W2119751640 cites W2142004616 @default.
- W2119751640 cites W2145137957 @default.
- W2119751640 cites W2147462014 @default.
- W2119751640 cites W2157791560 @default.
- W2119751640 cites W2158500407 @default.
- W2119751640 cites W2167322494 @default.
- W2119751640 cites W2171020828 @default.
- W2119751640 cites W2171421217 @default.
- W2119751640 cites W2172027870 @default.
- W2119751640 cites W2327070670 @default.
- W2119751640 cites W2395694920 @default.
- W2119751640 cites W2411143195 @default.
- W2119751640 cites W38847137 @default.
- W2119751640 doi "https://doi.org/10.4414/smw.2010.13080" @default.
- W2119751640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20927685" @default.
- W2119751640 hasPublicationYear "2010" @default.
- W2119751640 type Work @default.
- W2119751640 sameAs 2119751640 @default.
- W2119751640 citedByCount "52" @default.
- W2119751640 countsByYear W21197516402012 @default.