FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119753313> ?p ?o ?g. }

• W2119753313 endingPage "720" @default.
• W2119753313 startingPage "713" @default.
• W2119753313 abstract "Familial hypocalciuric hypercalcaemia (FHH) must be differentiated from primary hyperparathyroidism (PHPT) because prognosis and treatment differ. In daily practice this discrimination is often based on the renal calcium excretion or the calcium/creatinine clearance ratio (CCCR). However, the diagnostic performance of these variables is poorly documented.To appraise the power of various simple biochemical variables to differentiate between FHH and PHPT using calcium sensing receptor (CASR) gene analysis and histopathological findings as gold standards.Follow-up approach (direct design).We included 54 FHH patients (17 males and 37 females, aged 18-75 years) with clinically significant mutations in the CASR gene and 97 hypercalcaemic patients with histologically verified PHPT (17 males and 80 females, aged 19-86 years). All PHPT patients became normocalcaemic following successful neck exploration.Based on receiver operating characteristic (ROC) curve analysis, the CCCR was only marginally better, as judged by the area under curve (AUC = 0.923 +/- 0.021 (SE)), than the 24-h calcium/creatinine excretion ratio (AUC = 0.903 +/- 0.027) and the 24-h calcium excretion (AUC = 0.876 +/- 0.029). However, overlap performance analysis disclosed that the CCCR included fewer patients with PHPT together with the FHH patients than the other two variables at different cut-off points. Based on the ROC curve, the optimal cut-off point for diagnosing FHH using CCCR was < 0.0115, which yielded a diagnostic specificity of 0.88 and a sensitivity of 0.80. Overlap analysis revealed that a cut-off point for CCCR at < 0.020 would sample 98% (53/54) of all patients with FHH and include 35% (34/97) of the PHPT patients.Our results support the use of the CCCR as an initial screening test for FHH. We suggest a two-step diagnostic procedure, where the first step is based on the CCCR with a cut-off at < 0.020, and the second step is CASR gene analysis in patients with FHH or PHPT." @default.
• W2119753313 created "2016-06-24" @default.
• W2119753313 creator A5012244618 @default.
• W2119753313 creator A5022628217 @default.
• W2119753313 creator A5032270670 @default.
• W2119753313 creator A5048251955 @default.
• W2119753313 creator A5064914075 @default.
• W2119753313 creator A5074502655 @default.
• W2119753313 date "2008-11-01" @default.
• W2119753313 modified "2023-09-30" @default.
• W2119753313 title "Discriminative power of three indices of renal calcium excretion for the distinction between familial hypocalciuric hypercalcaemia and primary hyperparathyroidism: a follow-up study on methods" @default.
• W2119753313 cites W1515862717 @default.
• W2119753313 cites W1529750147 @default.
• W2119753313 cites W1973877046 @default.
• W2119753313 cites W1975297178 @default.
• W2119753313 cites W1980977888 @default.
• W2119753313 cites W1983966778 @default.
• W2119753313 cites W1988537358 @default.
• W2119753313 cites W1993154524 @default.
• W2119753313 cites W1998843632 @default.
• W2119753313 cites W2002072552 @default.
• W2119753313 cites W2005675355 @default.
• W2119753313 cites W2006500517 @default.
• W2119753313 cites W2006794593 @default.
• W2119753313 cites W2018861357 @default.
• W2119753313 cites W2024868345 @default.
• W2119753313 cites W2030731500 @default.
• W2119753313 cites W2041831912 @default.
• W2119753313 cites W2047030131 @default.
• W2119753313 cites W2055480926 @default.
• W2119753313 cites W2056497873 @default.
• W2119753313 cites W2067187074 @default.
• W2119753313 cites W2086695519 @default.
• W2119753313 cites W2091575199 @default.
• W2119753313 cites W2096812309 @default.
• W2119753313 cites W2097001761 @default.
• W2119753313 cites W2102398567 @default.
• W2119753313 cites W2105787596 @default.
• W2119753313 cites W2106856165 @default.
• W2119753313 cites W2111437902 @default.
• W2119753313 cites W2117821944 @default.
• W2119753313 cites W2121943809 @default.
• W2119753313 cites W2137266781 @default.
• W2119753313 cites W2139736883 @default.
• W2119753313 cites W2155880324 @default.
• W2119753313 cites W2412097855 @default.
• W2119753313 cites W4238148092 @default.
• W2119753313 doi "https://doi.org/10.1111/j.1365-2265.2008.03259.x" @default.
• W2119753313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18410554" @default.
• W2119753313 hasPublicationYear "2008" @default.
• W2119753313 type Work @default.
• W2119753313 sameAs 2119753313 @default.
• W2119753313 citedByCount "141" @default.
• W2119753313 countsByYear W21197533132012 @default.
• W2119753313 countsByYear W21197533132013 @default.
• W2119753313 countsByYear W21197533132014 @default.
• W2119753313 countsByYear W21197533132015 @default.
• W2119753313 countsByYear W21197533132016 @default.
• W2119753313 countsByYear W21197533132017 @default.
• W2119753313 countsByYear W21197533132018 @default.
• W2119753313 countsByYear W21197533132019 @default.
• W2119753313 countsByYear W21197533132020 @default.
• W2119753313 countsByYear W21197533132021 @default.
• W2119753313 countsByYear W21197533132022 @default.
• W2119753313 countsByYear W21197533132023 @default.
• W2119753313 crossrefType "journal-article" @default.
• W2119753313 hasAuthorship W2119753313A5012244618 @default.
• W2119753313 hasAuthorship W2119753313A5022628217 @default.
• W2119753313 hasAuthorship W2119753313A5032270670 @default.
• W2119753313 hasAuthorship W2119753313A5048251955 @default.
• W2119753313 hasAuthorship W2119753313A5064914075 @default.
• W2119753313 hasAuthorship W2119753313A5074502655 @default.
• W2119753313 hasConcept C10146269 @default.
• W2119753313 hasConcept C126322002 @default.
• W2119753313 hasConcept C126894567 @default.
• W2119753313 hasConcept C134018914 @default.
• W2119753313 hasConcept C142590548 @default.
• W2119753313 hasConcept C159641895 @default.
• W2119753313 hasConcept C178790620 @default.
• W2119753313 hasConcept C185592680 @default.
• W2119753313 hasConcept C2775945674 @default.
• W2119753313 hasConcept C2776183862 @default.
• W2119753313 hasConcept C2779053571 @default.
• W2119753313 hasConcept C2779674975 @default.
• W2119753313 hasConcept C2780306776 @default.
• W2119753313 hasConcept C2780643589 @default.
• W2119753313 hasConcept C2781208988 @default.
• W2119753313 hasConcept C519063684 @default.
• W2119753313 hasConcept C543218039 @default.
• W2119753313 hasConcept C58471807 @default.
• W2119753313 hasConcept C71924100 @default.
• W2119753313 hasConcept C76318530 @default.
• W2119753313 hasConcept C90924648 @default.
• W2119753313 hasConceptScore W2119753313C10146269 @default.
• W2119753313 hasConceptScore W2119753313C126322002 @default.
• W2119753313 hasConceptScore W2119753313C126894567 @default.
• W2119753313 hasConceptScore W2119753313C134018914 @default.
• W2119753313 hasConceptScore W2119753313C142590548 @default.

• next