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- W2119785384 startingPage "93" @default.
- W2119785384 abstract "In this review, I will suggest to divide all the approaches united now under common term “gene therapy” into two broad strategies of which the first one uses the methodology of targeted therapy with all its characteristics, but with genes in the role of agents targeted at a certain molecular component(s) presumably crucial for cancer maintenance. In contrast, the techniques of the other strategy are aimed at the destruction of tumors as a whole using the features shared by all cancers, for example relatively fast mitotic cell division or active angiogenesis. While the first strategy is “true” gene therapy, the second one is more like genetic surgery when a surgeon just cuts off a tumor with his scalpel and has no interest in knowing delicate mechanisms of cancer emergence and progression. I will try to substantiate the idea that the last strategy is the only right one, and its simplicity is paradoxically adequate to the super-complexity of tumors that originates from general complexity of cell regulation, strongly disturbed in tumor cells, and especially from the complexity of tumors as evolving cell populations, affecting also their ecological niche formed by neighboring normal cells and tissues. An analysis of the most widely used for such a “surgery” suicide gene/prodrug combinations will be presented in some more details." @default.
- W2119785384 created "2016-06-24" @default.
- W2119785384 creator A5045861044 @default.
- W2119785384 date "2009-09-01" @default.
- W2119785384 modified "2023-10-16" @default.
- W2119785384 title "Not gene therapy, but genetic surgery—the right strategy to attack cancer" @default.
- W2119785384 cites W121119440 @default.
- W2119785384 cites W1482809148 @default.
- W2119785384 cites W1489144311 @default.
- W2119785384 cites W1494984023 @default.
- W2119785384 cites W1540542144 @default.
- W2119785384 cites W1541316156 @default.
- W2119785384 cites W1544232861 @default.
- W2119785384 cites W1556094015 @default.
- W2119785384 cites W1565518567 @default.
- W2119785384 cites W1581549015 @default.
- W2119785384 cites W1650984530 @default.
- W2119785384 cites W1791027840 @default.
- W2119785384 cites W1915631065 @default.
- W2119785384 cites W1963729009 @default.
- W2119785384 cites W1966538775 @default.
- W2119785384 cites W1970949498 @default.
- W2119785384 cites W1970953413 @default.
- W2119785384 cites W1971092719 @default.
- W2119785384 cites W1971180252 @default.
- W2119785384 cites W1972265894 @default.
- W2119785384 cites W1973177211 @default.
- W2119785384 cites W1975278913 @default.
- W2119785384 cites W1978298636 @default.
- W2119785384 cites W1979127187 @default.
- W2119785384 cites W1980973208 @default.
- W2119785384 cites W1981748118 @default.
- W2119785384 cites W1981940030 @default.
- W2119785384 cites W1982118505 @default.
- W2119785384 cites W1982942806 @default.
- W2119785384 cites W1983080805 @default.
- W2119785384 cites W1983988727 @default.
- W2119785384 cites W1984209453 @default.
- W2119785384 cites W1987377236 @default.
- W2119785384 cites W1988450448 @default.
- W2119785384 cites W1988734973 @default.
- W2119785384 cites W1988946212 @default.
- W2119785384 cites W1990386018 @default.
- W2119785384 cites W1998543559 @default.
- W2119785384 cites W1999356404 @default.
- W2119785384 cites W1999782631 @default.
- W2119785384 cites W2004263531 @default.
- W2119785384 cites W2004273407 @default.
- W2119785384 cites W2004332616 @default.
- W2119785384 cites W2005540553 @default.
- W2119785384 cites W2006680407 @default.
- W2119785384 cites W2006922381 @default.
- W2119785384 cites W2008905972 @default.
- W2119785384 cites W2012124753 @default.
- W2119785384 cites W2012532522 @default.
- W2119785384 cites W2014780970 @default.
- W2119785384 cites W2017322644 @default.
- W2119785384 cites W2017482101 @default.
- W2119785384 cites W2017523822 @default.
- W2119785384 cites W2018614123 @default.
- W2119785384 cites W2022725703 @default.
- W2119785384 cites W2023200249 @default.
- W2119785384 cites W2024422011 @default.
- W2119785384 cites W2025822934 @default.
- W2119785384 cites W2027042410 @default.
- W2119785384 cites W2028074588 @default.
- W2119785384 cites W2031056725 @default.
- W2119785384 cites W2033133775 @default.
- W2119785384 cites W2033364737 @default.
- W2119785384 cites W2034269086 @default.
- W2119785384 cites W2035253718 @default.
- W2119785384 cites W2035867525 @default.
- W2119785384 cites W2039606117 @default.
- W2119785384 cites W2042026190 @default.
- W2119785384 cites W2042198997 @default.
- W2119785384 cites W2044063294 @default.
- W2119785384 cites W2046928699 @default.
- W2119785384 cites W2049309316 @default.
- W2119785384 cites W2051250328 @default.
- W2119785384 cites W2052845628 @default.
- W2119785384 cites W2054792292 @default.
- W2119785384 cites W2055628787 @default.
- W2119785384 cites W2056257137 @default.
- W2119785384 cites W2059815171 @default.
- W2119785384 cites W2060752753 @default.
- W2119785384 cites W2062809449 @default.
- W2119785384 cites W2062920754 @default.
- W2119785384 cites W2064208463 @default.
- W2119785384 cites W2065307682 @default.
- W2119785384 cites W2065543158 @default.
- W2119785384 cites W2068305486 @default.
- W2119785384 cites W2068932629 @default.
- W2119785384 cites W2069158666 @default.
- W2119785384 cites W2070898966 @default.
- W2119785384 cites W2071260213 @default.
- W2119785384 cites W2071663634 @default.
- W2119785384 cites W2074092467 @default.
- W2119785384 cites W2076429505 @default.