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• W2119786790 endingPage "565" @default.
• W2119786790 startingPage "532" @default.
• W2119786790 abstract "Mecamylamine hydrochloride was initially developed for its ganglion-blocking activity and has been marketed as an antihypertensive agent in the United States for >40 years. Several other potential therapeutic applications are being investigated, most of them focusing on the drug's ability to cross the blood-brain barrier and selectively antagonize neuronal nicotinic acetylcholine receptors. This central activity of mecamylamine is demonstrable at much lower doses than the effective antihypertensive dose, thus avoiding many of the bothersome side effects associated with the drug's inhibition of parasympathetic activity.Because investigations are being conducted in new patient populations, including pediatric patients, an update of the toxicity/risk profile of mecamylamine is timely. This review describes nonclinical and clinical data pertaining to the pharmacology, toxicity, and tolerability of mecamylamine, including some previously unpublished toxicology and clinical pharmacokinetics data. Potential new therapeutic applications are discussed, including the use of mecamylamine in treating autonomic dysreflexia; dependencies on nicotine, cocaine, and other substances of abuse; Tourette's syndrome; and other neuropsychiatric disorders.Information for this review of mecamylamine was identified through a search of MEDLINE from 1966 to the present, as well as from the master files of Merck & Co, Inc, the drug's original manufacturer, and Layton BioScience, Inc, its present manufacturer.The available data concerning potential new applications of mecamylamine, although sparse, suggest that the drug's toxicity/risk profile may be much improved at lower doses." @default.
• W2119786790 created "2016-06-24" @default.
• W2119786790 creator A5015972111 @default.
• W2119786790 date "2001-04-01" @default.
• W2119786790 modified "2023-10-16" @default.
• W2119786790 title "Mecamylamine: new therapeutic uses and toxicity/risk profile" @default.
• W2119786790 cites W1536211056 @default.
• W2119786790 cites W1554440479 @default.
• W2119786790 cites W1782902465 @default.
• W2119786790 cites W1799536240 @default.
• W2119786790 cites W1912050742 @default.
• W2119786790 cites W1920680810 @default.
• W2119786790 cites W1924882872 @default.
• W2119786790 cites W1948328726 @default.
• W2119786790 cites W1951152631 @default.
• W2119786790 cites W1952904147 @default.
• W2119786790 cites W1963679546 @default.
• W2119786790 cites W1963949960 @default.
• W2119786790 cites W1967402003 @default.
• W2119786790 cites W1968900945 @default.
• W2119786790 cites W1969169809 @default.
• W2119786790 cites W1969232823 @default.
• W2119786790 cites W1969661654 @default.
• W2119786790 cites W1970168883 @default.
• W2119786790 cites W1970797800 @default.
• W2119786790 cites W1972151658 @default.
• W2119786790 cites W1973170077 @default.
• W2119786790 cites W1974715317 @default.
• W2119786790 cites W1977171463 @default.
• W2119786790 cites W1979910403 @default.
• W2119786790 cites W1980052057 @default.
• W2119786790 cites W1981827116 @default.
• W2119786790 cites W1985448600 @default.
• W2119786790 cites W1987440991 @default.
• W2119786790 cites W1987994284 @default.
• W2119786790 cites W1995049152 @default.
• W2119786790 cites W1998292591 @default.
• W2119786790 cites W1998381966 @default.
• W2119786790 cites W1999504727 @default.
• W2119786790 cites W2003284269 @default.
• W2119786790 cites W2003499899 @default.
• W2119786790 cites W2003662972 @default.
• W2119786790 cites W2005807520 @default.
• W2119786790 cites W2007061188 @default.
• W2119786790 cites W2009879085 @default.
• W2119786790 cites W2011511235 @default.
• W2119786790 cites W2013001640 @default.
• W2119786790 cites W2014671682 @default.
• W2119786790 cites W2016105050 @default.
• W2119786790 cites W2020736970 @default.
• W2119786790 cites W2023016804 @default.
• W2119786790 cites W2026261866 @default.
• W2119786790 cites W2030144716 @default.
• W2119786790 cites W2034173380 @default.
• W2119786790 cites W2034477352 @default.
• W2119786790 cites W2034947167 @default.
• W2119786790 cites W2035663078 @default.
• W2119786790 cites W2035930525 @default.
• W2119786790 cites W2044381447 @default.
• W2119786790 cites W2045247843 @default.
• W2119786790 cites W2049302871 @default.
• W2119786790 cites W2050726047 @default.
• W2119786790 cites W2050836827 @default.
• W2119786790 cites W2051606745 @default.
• W2119786790 cites W2053198346 @default.
• W2119786790 cites W2056816471 @default.
• W2119786790 cites W2057831654 @default.
• W2119786790 cites W2059534793 @default.
• W2119786790 cites W2060438726 @default.
• W2119786790 cites W2061771087 @default.
• W2119786790 cites W2064706623 @default.
• W2119786790 cites W2064808023 @default.
• W2119786790 cites W2065537363 @default.
• W2119786790 cites W2065846404 @default.
• W2119786790 cites W2066790266 @default.
• W2119786790 cites W2066951615 @default.
• W2119786790 cites W2067524793 @default.
• W2119786790 cites W2068126223 @default.
• W2119786790 cites W2070075734 @default.
• W2119786790 cites W2070658602 @default.
• W2119786790 cites W2070840066 @default.
• W2119786790 cites W2074830812 @default.
• W2119786790 cites W2077445378 @default.
• W2119786790 cites W2077465343 @default.
• W2119786790 cites W2077496557 @default.
• W2119786790 cites W2079042918 @default.
• W2119786790 cites W2079373311 @default.
• W2119786790 cites W2081391428 @default.
• W2119786790 cites W2083068758 @default.
• W2119786790 cites W2087726392 @default.
• W2119786790 cites W2090817271 @default.
• W2119786790 cites W2094244493 @default.
• W2119786790 cites W2095191590 @default.
• W2119786790 cites W2105233285 @default.
• W2119786790 cites W2109789351 @default.
• W2119786790 cites W2118014735 @default.
• W2119786790 cites W2134056016 @default.
• W2119786790 cites W2136206420 @default.

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