Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119790151> ?p ?o ?g. }
- W2119790151 endingPage "7286" @default.
- W2119790151 startingPage "7281" @default.
- W2119790151 abstract "Tissue engineering of large bone defects is approached through implantation of autologous osteogenic cells, generally referred to as multipotent stromal cells or mesenchymal stem cells (MSCs). Animal-derived MSCs successfully bridge large bone defects, but models for ectopic bone formation as well as recent clinical trials demonstrate that bone formation by human MSCs (hMSCs) is inadequate. The expansion phase presents an attractive window to direct hMSCs by pharmacological manipulation, even though no profound effect on bone formation in vivo has been described so far using this approach. We report that activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines such as BMP-2, IGF-1, and IL-11. As a consequence, PKA activation results in robust in vivo bone formation by hMSCs derived from orthopedic patients." @default.
- W2119790151 created "2016-06-24" @default.
- W2119790151 creator A5000290629 @default.
- W2119790151 creator A5006132210 @default.
- W2119790151 creator A5038463863 @default.
- W2119790151 creator A5051045968 @default.
- W2119790151 creator A5051658337 @default.
- W2119790151 creator A5058224640 @default.
- W2119790151 creator A5060184516 @default.
- W2119790151 creator A5061712508 @default.
- W2119790151 creator A5068092989 @default.
- W2119790151 creator A5076565413 @default.
- W2119790151 creator A5077647224 @default.
- W2119790151 creator A5079436788 @default.
- W2119790151 date "2008-05-20" @default.
- W2119790151 modified "2023-10-16" @default.
- W2119790151 title "cAMP/PKA pathway activation in human mesenchymal stem cells <i>in vitro</i> results in robust bone formation <i>in vivo</i>" @default.
- W2119790151 cites W1607413909 @default.
- W2119790151 cites W1846468431 @default.
- W2119790151 cites W1970728706 @default.
- W2119790151 cites W1974973994 @default.
- W2119790151 cites W1983232134 @default.
- W2119790151 cites W1991162692 @default.
- W2119790151 cites W1994596418 @default.
- W2119790151 cites W2004247546 @default.
- W2119790151 cites W2004982583 @default.
- W2119790151 cites W2009861852 @default.
- W2119790151 cites W2017394391 @default.
- W2119790151 cites W2029143606 @default.
- W2119790151 cites W2031675589 @default.
- W2119790151 cites W2032740145 @default.
- W2119790151 cites W2033514910 @default.
- W2119790151 cites W2036122797 @default.
- W2119790151 cites W2037499635 @default.
- W2119790151 cites W2037536118 @default.
- W2119790151 cites W2037810763 @default.
- W2119790151 cites W2039140214 @default.
- W2119790151 cites W2040905054 @default.
- W2119790151 cites W2044456636 @default.
- W2119790151 cites W2045372041 @default.
- W2119790151 cites W2058226743 @default.
- W2119790151 cites W2060202533 @default.
- W2119790151 cites W2067045707 @default.
- W2119790151 cites W2069758652 @default.
- W2119790151 cites W2070466054 @default.
- W2119790151 cites W2074121447 @default.
- W2119790151 cites W2078489918 @default.
- W2119790151 cites W2080447461 @default.
- W2119790151 cites W2083116970 @default.
- W2119790151 cites W2090309504 @default.
- W2119790151 cites W2099028287 @default.
- W2119790151 cites W2107277218 @default.
- W2119790151 cites W2107477393 @default.
- W2119790151 cites W2122367477 @default.
- W2119790151 cites W2125916510 @default.
- W2119790151 cites W2134614924 @default.
- W2119790151 cites W2139171962 @default.
- W2119790151 cites W2144023435 @default.
- W2119790151 cites W2159999899 @default.
- W2119790151 cites W2163419242 @default.
- W2119790151 cites W262912863 @default.
- W2119790151 doi "https://doi.org/10.1073/pnas.0711190105" @default.
- W2119790151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2387183" @default.
- W2119790151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18490653" @default.
- W2119790151 hasPublicationYear "2008" @default.
- W2119790151 type Work @default.
- W2119790151 sameAs 2119790151 @default.
- W2119790151 citedByCount "187" @default.
- W2119790151 countsByYear W21197901512012 @default.
- W2119790151 countsByYear W21197901512013 @default.
- W2119790151 countsByYear W21197901512014 @default.
- W2119790151 countsByYear W21197901512015 @default.
- W2119790151 countsByYear W21197901512016 @default.
- W2119790151 countsByYear W21197901512017 @default.
- W2119790151 countsByYear W21197901512018 @default.
- W2119790151 countsByYear W21197901512019 @default.
- W2119790151 countsByYear W21197901512020 @default.
- W2119790151 countsByYear W21197901512021 @default.
- W2119790151 countsByYear W21197901512022 @default.
- W2119790151 countsByYear W21197901512023 @default.
- W2119790151 crossrefType "journal-article" @default.
- W2119790151 hasAuthorship W2119790151A5000290629 @default.
- W2119790151 hasAuthorship W2119790151A5006132210 @default.
- W2119790151 hasAuthorship W2119790151A5038463863 @default.
- W2119790151 hasAuthorship W2119790151A5051045968 @default.
- W2119790151 hasAuthorship W2119790151A5051658337 @default.
- W2119790151 hasAuthorship W2119790151A5058224640 @default.
- W2119790151 hasAuthorship W2119790151A5060184516 @default.
- W2119790151 hasAuthorship W2119790151A5061712508 @default.
- W2119790151 hasAuthorship W2119790151A5068092989 @default.
- W2119790151 hasAuthorship W2119790151A5076565413 @default.
- W2119790151 hasAuthorship W2119790151A5077647224 @default.
- W2119790151 hasAuthorship W2119790151A5079436788 @default.
- W2119790151 hasBestOaLocation W21197901511 @default.
- W2119790151 hasConcept C150903083 @default.
- W2119790151 hasConcept C185592680 @default.
- W2119790151 hasConcept C198826908 @default.
- W2119790151 hasConcept C202751555 @default.