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• W2119807130 endingPage "874" @default.
• W2119807130 startingPage "870" @default.
• W2119807130 abstract "The c-Jun NH 2 -terminal kinase (JNK) is activated when cells are exposed to ultraviolet (UV) radiation. However, the functional consequence of JNK activation in UV-irradiated cells has not been established. It is shown here that JNK is required for UV-induced apoptosis in primary murine embryonic fibroblasts. Fibroblasts with simultaneous targeted disruptions of all the functional Jnk genes were protected against UV-stimulated apoptosis. The absence of JNK caused a defect in the mitochondrial death signaling pathway, including the failure to release cytochrome c. These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway." @default.
• W2119807130 created "2016-06-24" @default.
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• W2119807130 date "2000-05-05" @default.
• W2119807130 modified "2023-10-17" @default.
• W2119807130 title "Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway" @default.
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• W2119807130 doi "https://doi.org/10.1126/science.288.5467.870" @default.
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