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- W2119813866 abstract "This review deals with a newly-developed category of antithrombotic drugs – the direct thrombin inhibitors. These agents interact with thrombin and block its catalytic activity on fibrinogen, platelets and other substrates. Heparin and its derivatives (low molecular weight heparins and the active pentasaccharide) inhibit thrombin and/or other coagulation serine proteases indirectly via antithrombin, and the warfarin-type drugs interfere with the synthesis of the precursors of the coagulation serine proteases. The direct thrombin inhibitors approved for clinical use at present (lepirudin, desirudin, bivalirudin, argatroban) and another in the advanced clinical testing stage (melagatran/ximelagatran), are the subject of this review. The chemical structure; kinetics of thrombin inhibition; pharmacokinetics and clinical use of each of these is discussed." @default.
- W2119813866 created "2016-06-24" @default.
- W2119813866 creator A5062864323 @default.
- W2119813866 date "2003-05-01" @default.
- W2119813866 modified "2023-09-25" @default.
- W2119813866 title "Direct thrombin inhibitors" @default.
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- W2119813866 doi "https://doi.org/10.1517/14656566.4.5.653" @default.
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