FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119821797> ?p ?o ?g. }

• W2119821797 endingPage "2187" @default.
• W2119821797 startingPage "2187" @default.
• W2119821797 abstract "Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: a systematic review Flora Zagouri,1 Theodoros N Sergentanis,2 Dimosthenis Chrysikos,2 Meletios-Athanassios Dimopoulos,1 Aristotle Bamias1 1Department of Clinical Therapeutics, Alexandra Hospital, 2First Propaedeutic Surgical Department, Hippokration Hospital, University of Athens, Athens, Greece Abstract: Ovarian cancer is the most lethal gynecologic malignancy; consequently, there is a need for effective therapies. Epothilones are microtubule-stabilizing agents that inhibit cell growth. Currently, patupilone and its four synthetic derivatives ixabepilone, BMS-310705, sagopilone, 20-desmethyl-20-methylsulfanyl epothilone B and epothilone D, as well as its derivative KOS-1584, are under clinical evaluation. This is the first systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines that synthesizes all available data emerging from trials and evaluates the efficacy and safety of epothilones in epithelial ovarian, primary fallopian tube, and primary peritoneal cancer. Despite the fact that epothilones have proven active in taxane-resistant settings in preclinical models, it is not yet clear from Phase II/III studies reviewed here that their clinical activity is superior to that of taxanes. Nevertheless, responses to epothilones have been observed in platinum-refractory/resistant ovarian cancer patients. Moreover, despite the shared mechanism of action of epothilones, their clinical profile seems clearly different, with diarrhea being the most common dose-limiting toxicity encountered with patupilone, whereas neutropenia and sensory neuropathy are the most common toxic effects observed with the other epothilones. In any case, randomized trials comparing epothilones with standard treatments seem warranted to define further the role of these agents, whereas biomarker analysis might further optimize patient selection. Keywords: ovarian cancer, epothilone, patupilone, ixabepilone, systematic review" @default.
• W2119821797 created "2016-06-24" @default.
• W2119821797 creator A5017011213 @default.
• W2119821797 creator A5033573338 @default.
• W2119821797 creator A5046758725 @default.
• W2119821797 creator A5047824781 @default.
• W2119821797 creator A5084731195 @default.
• W2119821797 date "2015-08-01" @default.
• W2119821797 modified "2023-09-25" @default.
• W2119821797 title "Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: a systematic review" @default.
• W2119821797 cites W1916389172 @default.
• W2119821797 cites W1979721718 @default.
• W2119821797 cites W2000779382 @default.
• W2119821797 cites W2011857790 @default.
• W2119821797 cites W2011950626 @default.
• W2119821797 cites W2012681221 @default.
• W2119821797 cites W2017807909 @default.
• W2119821797 cites W2020369220 @default.
• W2119821797 cites W2035908704 @default.
• W2119821797 cites W2051531718 @default.
• W2119821797 cites W2072090706 @default.
• W2119821797 cites W2075677078 @default.
• W2119821797 cites W2076811098 @default.
• W2119821797 cites W2088807388 @default.
• W2119821797 cites W2099243119 @default.
• W2119821797 cites W2101819946 @default.
• W2119821797 cites W2104966951 @default.
• W2119821797 cites W2109589295 @default.
• W2119821797 cites W2112913657 @default.
• W2119821797 cites W2115037148 @default.
• W2119821797 cites W2116059435 @default.
• W2119821797 cites W2116285792 @default.
• W2119821797 cites W2116928781 @default.
• W2119821797 cites W2127756768 @default.
• W2119821797 cites W2134169247 @default.
• W2119821797 cites W2139060364 @default.
• W2119821797 cites W2154812064 @default.
• W2119821797 cites W2158749015 @default.
• W2119821797 cites W2162645859 @default.
• W2119821797 cites W2165708803 @default.
• W2119821797 cites W2576440140 @default.
• W2119821797 cites W2588681363 @default.
• W2119821797 doi "https://doi.org/10.2147/ott.s77342" @default.
• W2119821797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4550178" @default.
• W2119821797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26316786" @default.
• W2119821797 hasPublicationYear "2015" @default.
• W2119821797 type Work @default.
• W2119821797 sameAs 2119821797 @default.
• W2119821797 citedByCount "11" @default.
• W2119821797 countsByYear W21198217972016 @default.
• W2119821797 countsByYear W21198217972017 @default.
• W2119821797 countsByYear W21198217972018 @default.
• W2119821797 countsByYear W21198217972019 @default.
• W2119821797 countsByYear W21198217972021 @default.
• W2119821797 crossrefType "journal-article" @default.
• W2119821797 hasAuthorship W2119821797A5017011213 @default.
• W2119821797 hasAuthorship W2119821797A5033573338 @default.
• W2119821797 hasAuthorship W2119821797A5046758725 @default.
• W2119821797 hasAuthorship W2119821797A5047824781 @default.
• W2119821797 hasAuthorship W2119821797A5084731195 @default.
• W2119821797 hasBestOaLocation W21198217971 @default.
• W2119821797 hasConcept C121608353 @default.
• W2119821797 hasConcept C126322002 @default.
• W2119821797 hasConcept C143998085 @default.
• W2119821797 hasConcept C185592680 @default.
• W2119821797 hasConcept C21951064 @default.
• W2119821797 hasConcept C2775883341 @default.
• W2119821797 hasConcept C2775930923 @default.
• W2119821797 hasConcept C2777249960 @default.
• W2119821797 hasConcept C2777511904 @default.
• W2119821797 hasConcept C2777526313 @default.
• W2119821797 hasConcept C2779194965 @default.
• W2119821797 hasConcept C2780427987 @default.
• W2119821797 hasConcept C2908737170 @default.
• W2119821797 hasConcept C29456083 @default.
• W2119821797 hasConcept C502942594 @default.
• W2119821797 hasConcept C530470458 @default.
• W2119821797 hasConcept C54355233 @default.
• W2119821797 hasConcept C71924100 @default.
• W2119821797 hasConcept C86803240 @default.
• W2119821797 hasConceptScore W2119821797C121608353 @default.
• W2119821797 hasConceptScore W2119821797C126322002 @default.
• W2119821797 hasConceptScore W2119821797C143998085 @default.
• W2119821797 hasConceptScore W2119821797C185592680 @default.
• W2119821797 hasConceptScore W2119821797C21951064 @default.
• W2119821797 hasConceptScore W2119821797C2775883341 @default.
• W2119821797 hasConceptScore W2119821797C2775930923 @default.
• W2119821797 hasConceptScore W2119821797C2777249960 @default.
• W2119821797 hasConceptScore W2119821797C2777511904 @default.
• W2119821797 hasConceptScore W2119821797C2777526313 @default.
• W2119821797 hasConceptScore W2119821797C2779194965 @default.
• W2119821797 hasConceptScore W2119821797C2780427987 @default.
• W2119821797 hasConceptScore W2119821797C2908737170 @default.
• W2119821797 hasConceptScore W2119821797C29456083 @default.
• W2119821797 hasConceptScore W2119821797C502942594 @default.
• W2119821797 hasConceptScore W2119821797C530470458 @default.
• W2119821797 hasConceptScore W2119821797C54355233 @default.
• W2119821797 hasConceptScore W2119821797C71924100 @default.

• next