Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119828989> ?p ?o ?g. }
- W2119828989 endingPage "1956" @default.
- W2119828989 startingPage "1945" @default.
- W2119828989 abstract "Although numerous studies have implicated the sphingolipid ceramide in the induction of cell death, a causative function of ceramide in caspase-dependent apoptosis remains a highly debated issue. Here, we show that ceramide is a key mediator of a distinct route to programmed cell death (PCD), i.e., caspase-independent PCD. Under conditions where apoptosis is either not initiated or actively inhibited, TNF induces caspase-independent PCD in L929 fibrosarcoma cells, NIH3T3 fibroblasts, human leukemic Jurkat T cells, and lung fibroblasts by increasing intracellular ceramide levels prior to the onset of cell death. Survival is significantly enhanced when ceramide accumulation is prevented, as demonstrated in fibroblasts genetically deficient for acid sphingomyelinase, in L929 cells overexpressing acid ceramidase, by pharmacological intervention, or by RNA interference. Jurkat cells deficient for receptor-interacting protein 1 (RIP1) do not accumulate ceramide and therefore are fully resistant to caspase-independent PCD whereas Jurkat cells overexpressing the mitochondrial protein Bcl-2 are partially protected, implicating RIP1 and mitochondria as components of the ceramide death pathway. Our data point to a role of caspases (but not cathepsins) in suppressing the ceramide death pathway under physiological conditions. Moreover, clonogenic survival of tumor cells is clearly reduced by induction of the ceramide death pathway, promising additional options for the development of novel tumor therapies." @default.
- W2119828989 created "2016-06-24" @default.
- W2119828989 creator A5033710694 @default.
- W2119828989 creator A5040120305 @default.
- W2119828989 creator A5049862048 @default.
- W2119828989 creator A5057105110 @default.
- W2119828989 creator A5064246652 @default.
- W2119828989 creator A5064926977 @default.
- W2119828989 creator A5069823119 @default.
- W2119828989 creator A5070597784 @default.
- W2119828989 creator A5087688135 @default.
- W2119828989 date "2005-12-01" @default.
- W2119828989 modified "2023-10-07" @default.
- W2119828989 title "Ceramide mediates caspase‐independent programmed cell death" @default.
- W2119828989 cites W135294775 @default.
- W2119828989 cites W1510210099 @default.
- W2119828989 cites W1523845694 @default.
- W2119828989 cites W1535433473 @default.
- W2119828989 cites W1604468403 @default.
- W2119828989 cites W1976133860 @default.
- W2119828989 cites W1981356615 @default.
- W2119828989 cites W1985225201 @default.
- W2119828989 cites W1988728998 @default.
- W2119828989 cites W1990084557 @default.
- W2119828989 cites W2000973050 @default.
- W2119828989 cites W2008265157 @default.
- W2119828989 cites W2009936156 @default.
- W2119828989 cites W2013765881 @default.
- W2119828989 cites W2015541389 @default.
- W2119828989 cites W2019107970 @default.
- W2119828989 cites W2023073081 @default.
- W2119828989 cites W2034915619 @default.
- W2119828989 cites W2035839114 @default.
- W2119828989 cites W2041576624 @default.
- W2119828989 cites W2047482683 @default.
- W2119828989 cites W2053736456 @default.
- W2119828989 cites W2054260525 @default.
- W2119828989 cites W2062359158 @default.
- W2119828989 cites W2066237635 @default.
- W2119828989 cites W2070005836 @default.
- W2119828989 cites W2076875353 @default.
- W2119828989 cites W2091286689 @default.
- W2119828989 cites W2092562916 @default.
- W2119828989 cites W2096012158 @default.
- W2119828989 cites W2096378217 @default.
- W2119828989 cites W2104205504 @default.
- W2119828989 cites W2107468514 @default.
- W2119828989 cites W2114348299 @default.
- W2119828989 cites W2114557817 @default.
- W2119828989 cites W2123149430 @default.
- W2119828989 cites W2130007939 @default.
- W2119828989 cites W2133821029 @default.
- W2119828989 cites W2135233980 @default.
- W2119828989 cites W2135687585 @default.
- W2119828989 cites W2149388384 @default.
- W2119828989 cites W2152184881 @default.
- W2119828989 cites W2166766769 @default.
- W2119828989 cites W4248474603 @default.
- W2119828989 doi "https://doi.org/10.1096/fj.05-3726com" @default.
- W2119828989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16319138" @default.
- W2119828989 hasPublicationYear "2005" @default.
- W2119828989 type Work @default.
- W2119828989 sameAs 2119828989 @default.
- W2119828989 citedByCount "113" @default.
- W2119828989 countsByYear W21198289892012 @default.
- W2119828989 countsByYear W21198289892013 @default.
- W2119828989 countsByYear W21198289892014 @default.
- W2119828989 countsByYear W21198289892015 @default.
- W2119828989 countsByYear W21198289892016 @default.
- W2119828989 countsByYear W21198289892017 @default.
- W2119828989 countsByYear W21198289892018 @default.
- W2119828989 countsByYear W21198289892019 @default.
- W2119828989 countsByYear W21198289892020 @default.
- W2119828989 countsByYear W21198289892021 @default.
- W2119828989 countsByYear W21198289892022 @default.
- W2119828989 countsByYear W21198289892023 @default.
- W2119828989 crossrefType "journal-article" @default.
- W2119828989 hasAuthorship W2119828989A5033710694 @default.
- W2119828989 hasAuthorship W2119828989A5040120305 @default.
- W2119828989 hasAuthorship W2119828989A5049862048 @default.
- W2119828989 hasAuthorship W2119828989A5057105110 @default.
- W2119828989 hasAuthorship W2119828989A5064246652 @default.
- W2119828989 hasAuthorship W2119828989A5064926977 @default.
- W2119828989 hasAuthorship W2119828989A5069823119 @default.
- W2119828989 hasAuthorship W2119828989A5070597784 @default.
- W2119828989 hasAuthorship W2119828989A5087688135 @default.
- W2119828989 hasConcept C170493617 @default.
- W2119828989 hasConcept C179464577 @default.
- W2119828989 hasConcept C180899940 @default.
- W2119828989 hasConcept C190283241 @default.
- W2119828989 hasConcept C203014093 @default.
- W2119828989 hasConcept C2776090121 @default.
- W2119828989 hasConcept C2777851122 @default.
- W2119828989 hasConcept C2781457462 @default.
- W2119828989 hasConcept C31573885 @default.
- W2119828989 hasConcept C48297814 @default.
- W2119828989 hasConcept C502942594 @default.
- W2119828989 hasConcept C55493867 @default.