FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119847724> ?p ?o ?g. }

• W2119847724 endingPage "403" @default.
• W2119847724 startingPage "397" @default.
• W2119847724 abstract "<b>Background:</b> Eotaxin (CCL11) is a small protein produced in the lungs of patients with asthma, and is a potent chemoattractant for eosinophils. <b>Aim:</b> To elucidate the role of eotaxin in asthma by an association study of functional and novel <i>eotaxin</i> polymorphisms in case–control and family-based study designs. <b>Methods:</b><i>Eotaxin</i> +67G/A, –384A/G and –426C/T single-nucleotide polymorphisms and a hexanucleotide (<i>GAAGGA</i>)_n repeat 10.9 kb upstream of the gene were genotyped in a cohort of age, sex and ethnically matched patients with asthma (n = 235) and healthy controls (n = 239), and also in a study population of 230 families with asthma recruited from north/northwest India. Total serum IgE (TsIgE) and plasma eotaxin levels were measured using ELISA. <b>Results:</b> +67G/A polymorphism was found to be significantly associated with asthma in case–control (p = 0.009) and family-based studies (p = 0.006). Its functional role, as it was correlated with plasma eotaxin levels (p = 0.006), was also demonstrated. Further, –384C/T single-nucleotide polymorphism was found to be significantly associated with log₁₀ TsIgE (p = 0.016 in case–control and p = 0.018 in families) and eotaxin levels (p = 0.007). Most interestingly, for the first time, a highly significant association of the newly studied (<i>GAAGGA</i>)_n hexanucleotide repeat with asthma (p = 3×10⁻⁶), log₁₀TsIgE (p = 0.006) and eotaxin levels (p = 0.004) was observed. G_A_C_8 was also identified as an important risk haplotype associated with high TsIgE and plasma eotaxin levels. <b>Conclusions:</b> This study provides further evidence that <i>eotaxin</i> polymorphisms are associated with the development of asthma by regulating eotaxin levels and reinforces towards the scanning of other chemokine genes present at <i>17q21</i> locus for their association with asthma and related phenotypes." @default.
• W2119847724 created "2016-06-24" @default.
• W2119847724 creator A5003091077 @default.
• W2119847724 creator A5004934944 @default.
• W2119847724 creator A5009284223 @default.
• W2119847724 creator A5036638461 @default.
• W2119847724 creator A5040811919 @default.
• W2119847724 creator A5044100781 @default.
• W2119847724 creator A5057600067 @default.
• W2119847724 date "2007-02-27" @default.
• W2119847724 modified "2023-10-14" @default.
• W2119847724 title "A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels" @default.
• W2119847724 cites W1483013948 @default.
• W2119847724 cites W1833894873 @default.
• W2119847724 cites W1968836112 @default.
• W2119847724 cites W1973188423 @default.
• W2119847724 cites W1985264526 @default.
• W2119847724 cites W2013132903 @default.
• W2119847724 cites W2016226467 @default.
• W2119847724 cites W2024973823 @default.
• W2119847724 cites W2029268155 @default.
• W2119847724 cites W2037321991 @default.
• W2119847724 cites W2040783402 @default.
• W2119847724 cites W2046829995 @default.
• W2119847724 cites W2048988599 @default.
• W2119847724 cites W2052260815 @default.
• W2119847724 cites W2055527378 @default.
• W2119847724 cites W2058282328 @default.
• W2119847724 cites W2058385347 @default.
• W2119847724 cites W2067714902 @default.
• W2119847724 cites W2086286256 @default.
• W2119847724 cites W2087929235 @default.
• W2119847724 cites W2097504226 @default.
• W2119847724 cites W2110755408 @default.
• W2119847724 cites W2123478982 @default.
• W2119847724 cites W2131334015 @default.
• W2119847724 cites W2135466760 @default.
• W2119847724 cites W2164141929 @default.
• W2119847724 cites W2323128871 @default.
• W2119847724 cites W24520786 @default.
• W2119847724 cites W4240211429 @default.
• W2119847724 doi "https://doi.org/10.1136/jmg.2006.046607" @default.
• W2119847724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2740889" @default.
• W2119847724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17220216" @default.
• W2119847724 hasPublicationYear "2007" @default.
• W2119847724 type Work @default.
• W2119847724 sameAs 2119847724 @default.
• W2119847724 citedByCount "23" @default.
• W2119847724 countsByYear W21198477242012 @default.
• W2119847724 countsByYear W21198477242013 @default.
• W2119847724 countsByYear W21198477242014 @default.
• W2119847724 countsByYear W21198477242015 @default.
• W2119847724 countsByYear W21198477242016 @default.
• W2119847724 countsByYear W21198477242018 @default.
• W2119847724 countsByYear W21198477242022 @default.
• W2119847724 countsByYear W21198477242023 @default.
• W2119847724 crossrefType "journal-article" @default.
• W2119847724 hasAuthorship W2119847724A5003091077 @default.
• W2119847724 hasAuthorship W2119847724A5004934944 @default.
• W2119847724 hasAuthorship W2119847724A5009284223 @default.
• W2119847724 hasAuthorship W2119847724A5036638461 @default.
• W2119847724 hasAuthorship W2119847724A5040811919 @default.
• W2119847724 hasAuthorship W2119847724A5044100781 @default.
• W2119847724 hasAuthorship W2119847724A5057600067 @default.
• W2119847724 hasBestOaLocation W21198477242 @default.
• W2119847724 hasConcept C104317684 @default.
• W2119847724 hasConcept C135763542 @default.
• W2119847724 hasConcept C141105273 @default.
• W2119847724 hasConcept C153209595 @default.
• W2119847724 hasConcept C159654299 @default.
• W2119847724 hasConcept C203014093 @default.
• W2119847724 hasConcept C2776042228 @default.
• W2119847724 hasConcept C2777037409 @default.
• W2119847724 hasConcept C2777716647 @default.
• W2119847724 hasConcept C2780590879 @default.
• W2119847724 hasConcept C2908647359 @default.
• W2119847724 hasConcept C54355233 @default.
• W2119847724 hasConcept C71924100 @default.
• W2119847724 hasConcept C86803240 @default.
• W2119847724 hasConcept C99454951 @default.
• W2119847724 hasConceptScore W2119847724C104317684 @default.
• W2119847724 hasConceptScore W2119847724C135763542 @default.
• W2119847724 hasConceptScore W2119847724C141105273 @default.
• W2119847724 hasConceptScore W2119847724C153209595 @default.
• W2119847724 hasConceptScore W2119847724C159654299 @default.
• W2119847724 hasConceptScore W2119847724C203014093 @default.
• W2119847724 hasConceptScore W2119847724C2776042228 @default.
• W2119847724 hasConceptScore W2119847724C2777037409 @default.
• W2119847724 hasConceptScore W2119847724C2777716647 @default.
• W2119847724 hasConceptScore W2119847724C2780590879 @default.
• W2119847724 hasConceptScore W2119847724C2908647359 @default.
• W2119847724 hasConceptScore W2119847724C54355233 @default.
• W2119847724 hasConceptScore W2119847724C71924100 @default.
• W2119847724 hasConceptScore W2119847724C86803240 @default.
• W2119847724 hasConceptScore W2119847724C99454951 @default.
• W2119847724 hasIssue "6" @default.
• W2119847724 hasLocation W21198477241 @default.
• W2119847724 hasLocation W21198477242 @default.

• next