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- W2119869146 abstract "The pharmacokinetics of triamcinolone acetonide were studied after intravenous (2 mg), oral (5 mg), and inhaled (2 mg) administration. Triamcinolone acetonide concentrations were measured in plasma by high‐performance liquid chromatography/radioimmunoassay. After intravenous administration, triamcinolone acetonide was eliminated with a total body clearance of 37 L/h and a half‐life of 2.0 hours. The volume of distribution was 103 L, and oral bioavailability averaged 23%. Absorption was rapid, achieving maximum triamcinolone acetonide levels of 10.5 ng/mL after 1 hour. After inhalation, bioavailability averaged 22% with maximum levels of 2.0 ng/mL observed after 2.1 hours. The resulting systemic levels for all three treatments caused a significant decrease in the number of lymphocytes in blood." @default.
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- W2119869146 date "1995-03-01" @default.
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- W2119869146 title "Pharmacokinetics of Triamcinolone Acetonide After Intravenous, Oral, and Inhaled Administration" @default.
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- W2119869146 doi "https://doi.org/10.1002/j.1552-4604.1995.tb04064.x" @default.
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