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- W2119876318 endingPage "6957" @default.
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- W2119876318 abstract "ABSTRACT In yeast, the transcriptional adaptor yeast Ada2 (yAda2) is a part of the multicomponent SAGA complex, which possesses histone acetyltransferase activity through action of the yGcn5 catalytic enzyme. yAda2, among several SAGA proteins, serves to recruit SAGA to genes via interactions with promoter-bound transcription factors. Here we report identification of a new human Ada2 homologue, hAda2β. Ada2β differs both biochemically and functionally from the previously characterized hAda2α, which is a stable component of the human PCAF (human Gcn5 homologue) acetylase complex. Ada2β, relative to Ada2α, interacted selectively, although not stably, with the Gcn5-containing histone acetylation complex TFTC/STAGA. In addition, Ada2β interacted with Baf57 (a component of the human Swi/Snf complex) in a yeast two-hybrid screen and associated with human Swi/Snf in vitro. In functional assays, hAda2β (but not Ada2α), working in concert with Gcn5 (but not PCAF) or Brg1 (the catalytic component of hSwi/Snf complex), increased transcription via the B-cell-specific transcription factor Pax5/BSAP. These findings support the view that Gcn5 and PCAF have distinct roles in vivo and suggest a new mechanism of coactivator function, in which a single adaptor protein (Ada2β) can coordinate targeting of both histone acetylation and chromatin remodeling activities." @default.
- W2119876318 created "2016-06-24" @default.
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- W2119876318 date "2003-10-01" @default.
- W2119876318 modified "2023-10-18" @default.
- W2119876318 title "A Novel Human Ada2 Homologue Functions with Gcn5 or Brg1 To Coactivate Transcription" @default.
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- W2119876318 cites W1863364305 @default.
- W2119876318 cites W1954246782 @default.
- W2119876318 cites W1963506471 @default.
- W2119876318 cites W1963553696 @default.
- W2119876318 cites W1967046460 @default.
- W2119876318 cites W1968029309 @default.
- W2119876318 cites W1968044233 @default.
- W2119876318 cites W1971842995 @default.
- W2119876318 cites W1975580948 @default.
- W2119876318 cites W1986263057 @default.
- W2119876318 cites W1991258942 @default.
- W2119876318 cites W1992593700 @default.
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- W2119876318 cites W2008738118 @default.
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- W2119876318 cites W2023437193 @default.
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- W2119876318 cites W2032645409 @default.
- W2119876318 cites W2034427054 @default.
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- W2119876318 cites W2066696278 @default.
- W2119876318 cites W2073905722 @default.
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- W2119876318 doi "https://doi.org/10.1128/mcb.23.19.6944-6957.2003" @default.
- W2119876318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/193946" @default.
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