FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119882867> ?p ?o ?g. }

• W2119882867 endingPage "R417" @default.
• W2119882867 startingPage "R408" @default.
• W2119882867 abstract "A change in mRNA stability alters the abundance of mRNA available for translation and is emerging as a critical pathway influencing gene expression. Variations in the stability of functional and regulatory mitochondrial proteins may contribute to the divergent mitochondrial densities observed in striated muscle. Thus we hypothesized that the stability of mRNAs encoding for regulatory nuclear and mitochondrial transcription factors would be inversely proportional to muscle oxidative capacity and would be facilitated by the activity of RNA binding proteins (RBPs). The stability of mitochondrial transcription factor A (Tfam), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), and nuclear respiratory factor 2α (NRF-2α) mRNA was assessed in striated muscles with distinct oxidative capacities using in vitro decay assays. All three mitochondrial regulators were rapidly degraded in cardiac and slow-twitch red (STR) muscle, resulting in a ∼60–65% lower ( P < 0.05) mRNA half-life ( t 1/2 ) compared with fast-twitch white (FTW) fibers. This accelerated rate of Tfam mRNA decay was matched by a 2.5-fold increase in Tfam transcription in slow- compared with fast-twitch muscle ( P = 0.05). Protein expression of four unique RBPs [AU-rich binding factor 1 (AUF1), human antigen R (HuR), KH-homology splicing regulatory protein (KSRP), and CUG binding protein 1 (CUGBP1)] believed to modulate mRNA stability was elevated in cardiac and STR muscles ( P < 0.05) and was moderately associated with the decay of Tfam, PGC-1α, and NRF-2α mRNA. Variable rates of transcript degradation were apparent when comparing all transcripts within the same muscle type. Thus the distribution of RBPs appears to follow a fiber-type specific pattern and subsequently functions to alter the stability of specific mitochondrial regulators in a transcript- and tissue-specific fashion." @default.
• W2119882867 created "2016-06-24" @default.
• W2119882867 creator A5029188041 @default.
• W2119882867 creator A5076563879 @default.
• W2119882867 creator A5082704800 @default.
• W2119882867 creator A5083134945 @default.
• W2119882867 date "2012-08-15" @default.
• W2119882867 modified "2023-10-18" @default.
• W2119882867 title "mRNA stability as a function of striated muscle oxidative capacity" @default.
• W2119882867 cites W147388322 @default.
• W2119882867 cites W1579386532 @default.
• W2119882867 cites W1790510139 @default.
• W2119882867 cites W1797307354 @default.
• W2119882867 cites W1877856201 @default.
• W2119882867 cites W1965589095 @default.
• W2119882867 cites W1967470178 @default.
• W2119882867 cites W1970491226 @default.
• W2119882867 cites W19715912 @default.
• W2119882867 cites W1973555390 @default.
• W2119882867 cites W1979614091 @default.
• W2119882867 cites W1983342911 @default.
• W2119882867 cites W1989504358 @default.
• W2119882867 cites W1992264649 @default.
• W2119882867 cites W1995586763 @default.
• W2119882867 cites W1997312454 @default.
• W2119882867 cites W1999793652 @default.
• W2119882867 cites W2002203989 @default.
• W2119882867 cites W2006768369 @default.
• W2119882867 cites W2008320899 @default.
• W2119882867 cites W2014209078 @default.
• W2119882867 cites W2015397524 @default.
• W2119882867 cites W2021583109 @default.
• W2119882867 cites W2026011189 @default.
• W2119882867 cites W2027325614 @default.
• W2119882867 cites W2029706883 @default.
• W2119882867 cites W2033665082 @default.
• W2119882867 cites W2037079787 @default.
• W2119882867 cites W2039357236 @default.
• W2119882867 cites W2045342567 @default.
• W2119882867 cites W2048357928 @default.
• W2119882867 cites W2050324319 @default.
• W2119882867 cites W2054791134 @default.
• W2119882867 cites W2061443977 @default.
• W2119882867 cites W2063572593 @default.
• W2119882867 cites W2066961060 @default.
• W2119882867 cites W2073289591 @default.
• W2119882867 cites W2073424121 @default.
• W2119882867 cites W2076510291 @default.
• W2119882867 cites W2077415858 @default.
• W2119882867 cites W2077643233 @default.
• W2119882867 cites W2080532845 @default.
• W2119882867 cites W2086510997 @default.
• W2119882867 cites W2096259566 @default.
• W2119882867 cites W2102726577 @default.
• W2119882867 cites W2107945166 @default.
• W2119882867 cites W2113515610 @default.
• W2119882867 cites W2118397007 @default.
• W2119882867 cites W2121453437 @default.
• W2119882867 cites W2127337265 @default.
• W2119882867 cites W2128551987 @default.
• W2119882867 cites W2128688272 @default.
• W2119882867 cites W2130932394 @default.
• W2119882867 cites W2138348512 @default.
• W2119882867 cites W2140751228 @default.
• W2119882867 cites W2145796537 @default.
• W2119882867 cites W2148599023 @default.
• W2119882867 cites W2153401206 @default.
• W2119882867 cites W2153696328 @default.
• W2119882867 cites W2155984955 @default.
• W2119882867 cites W2156933957 @default.
• W2119882867 cites W2159376549 @default.
• W2119882867 cites W2164533103 @default.
• W2119882867 cites W2165700891 @default.
• W2119882867 cites W2167635085 @default.
• W2119882867 cites W2168760462 @default.
• W2119882867 cites W2169276115 @default.
• W2119882867 cites W2170542547 @default.
• W2119882867 cites W2173518786 @default.
• W2119882867 cites W2182383789 @default.
• W2119882867 cites W2288839112 @default.
• W2119882867 cites W2474050726 @default.
• W2119882867 cites W4214816144 @default.
• W2119882867 cites W4235711277 @default.
• W2119882867 cites W4292399258 @default.
• W2119882867 cites W4293247451 @default.
• W2119882867 cites W58743570 @default.
• W2119882867 doi "https://doi.org/10.1152/ajpregu.00085.2012" @default.
• W2119882867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22718808" @default.
• W2119882867 hasPublicationYear "2012" @default.
• W2119882867 type Work @default.
• W2119882867 sameAs 2119882867 @default.
• W2119882867 citedByCount "19" @default.
• W2119882867 countsByYear W21198828672012 @default.
• W2119882867 countsByYear W21198828672013 @default.
• W2119882867 countsByYear W21198828672014 @default.
• W2119882867 countsByYear W21198828672015 @default.
• W2119882867 countsByYear W21198828672018 @default.
• W2119882867 countsByYear W21198828672019 @default.

• next