FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119906557> ?p ?o ?g. }

• W2119906557 endingPage "414" @default.
• W2119906557 startingPage "405" @default.
• W2119906557 abstract "Evidence indicates that subtle abnormalities in GC (glucocorticoid) plasma concentrations and/or in tissue sensitivity to GCs are important in the metabolic syndrome, and it is generally agreed that GCs induce insulin resistance. In addition, it was recently reported that short-term exposure to GCs reduced the insulinotropic effects of the incretin GLP-1 (glucagon-like peptide 1). However, although defective GLP-1 secretion has been correlated with insulin resistance, potential direct effects of GCs on GLP-1-producing L-cell function in terms of GLP-1 secretion and apoptosis have not been studied in any greater detail. In the present study, we sought to determine whether GCs could exert direct effects on GLP-1-producing L-cells in terms of GLP-1 secretion and cell viability. We demonstrate that the GR (glucocorticoid receptor) is expressed in GLP-1-producing cells, where GR activation in response to dexamethasone induces SGK1 (serum- and glucocorticoid-inducible kinase 1) expression, but did not influence preproglucagon expression or cell viability. In addition, dexamethasone treatment of enteroendocrine GLUTag cells reduced GLP-1 secretion induced by glucose, 2-deoxy-D-glucose, fructose and potassium, whereas the secretory response to a phorbol ester was unaltered. Furthermore, in vivo administration of dexamethasone to rats reduced the circulating levels of GLP-1 concurrent with induction of insulin resistance and glucose intolerance. We can conclude that GR activation in GLP-1-producing cells will diminish the secretory responsiveness of these cells to subsequent carbohydrate stimulation. These effects may not only elucidate the pathogenesis of steroid diabetes, but could ultimately contribute to the identification of novel molecular targets for controlling incretin secretion." @default.
• W2119906557 created "2016-06-24" @default.
• W2119906557 creator A5040559748 @default.
• W2119906557 creator A5040633767 @default.
• W2119906557 creator A5072693959 @default.
• W2119906557 creator A5073458837 @default.
• W2119906557 date "2015-06-11" @default.
• W2119906557 modified "2023-10-10" @default.
• W2119906557 title "Glucocorticoids suppress GLP-1 secretion: possible contribution to their diabetogenic effects" @default.
• W2119906557 cites W1488594793 @default.
• W2119906557 cites W1610975395 @default.
• W2119906557 cites W1775749144 @default.
• W2119906557 cites W1943482912 @default.
• W2119906557 cites W1964439024 @default.
• W2119906557 cites W1964995085 @default.
• W2119906557 cites W1983013527 @default.
• W2119906557 cites W1986869382 @default.
• W2119906557 cites W1991178295 @default.
• W2119906557 cites W1991905992 @default.
• W2119906557 cites W2010671489 @default.
• W2119906557 cites W2031820342 @default.
• W2119906557 cites W2038148790 @default.
• W2119906557 cites W2045600065 @default.
• W2119906557 cites W2048876290 @default.
• W2119906557 cites W2078115857 @default.
• W2119906557 cites W2095395905 @default.
• W2119906557 cites W2095491277 @default.
• W2119906557 cites W2095831813 @default.
• W2119906557 cites W2096689446 @default.
• W2119906557 cites W2100232797 @default.
• W2119906557 cites W2104572166 @default.
• W2119906557 cites W2104954391 @default.
• W2119906557 cites W2105726125 @default.
• W2119906557 cites W2106798564 @default.
• W2119906557 cites W2112292567 @default.
• W2119906557 cites W2121497054 @default.
• W2119906557 cites W2125943439 @default.
• W2119906557 cites W2130517208 @default.
• W2119906557 cites W2145818242 @default.
• W2119906557 cites W2155881904 @default.
• W2119906557 cites W2161163854 @default.
• W2119906557 cites W2161358527 @default.
• W2119906557 cites W2165403578 @default.
• W2119906557 cites W2166637902 @default.
• W2119906557 cites W2764852464 @default.
• W2119906557 cites W4231664412 @default.
• W2119906557 doi "https://doi.org/10.1042/cs20140719" @default.
• W2119906557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25853863" @default.
• W2119906557 hasPublicationYear "2015" @default.
• W2119906557 type Work @default.
• W2119906557 sameAs 2119906557 @default.
• W2119906557 citedByCount "20" @default.
• W2119906557 countsByYear W21199065572015 @default.
• W2119906557 countsByYear W21199065572016 @default.
• W2119906557 countsByYear W21199065572017 @default.
• W2119906557 countsByYear W21199065572018 @default.
• W2119906557 countsByYear W21199065572019 @default.
• W2119906557 countsByYear W21199065572020 @default.
• W2119906557 countsByYear W21199065572021 @default.
• W2119906557 countsByYear W21199065572022 @default.
• W2119906557 countsByYear W21199065572023 @default.
• W2119906557 crossrefType "journal-article" @default.
• W2119906557 hasAuthorship W2119906557A5040559748 @default.
• W2119906557 hasAuthorship W2119906557A5040633767 @default.
• W2119906557 hasAuthorship W2119906557A5072693959 @default.
• W2119906557 hasAuthorship W2119906557A5073458837 @default.
• W2119906557 hasConcept C103395026 @default.
• W2119906557 hasConcept C126322002 @default.
• W2119906557 hasConcept C134018914 @default.
• W2119906557 hasConcept C1491633281 @default.
• W2119906557 hasConcept C2776398474 @default.
• W2119906557 hasConcept C2777180221 @default.
• W2119906557 hasConcept C2777391703 @default.
• W2119906557 hasConcept C2778881409 @default.
• W2119906557 hasConcept C2779306644 @default.
• W2119906557 hasConcept C2780401358 @default.
• W2119906557 hasConcept C2780841215 @default.
• W2119906557 hasConcept C46699223 @default.
• W2119906557 hasConcept C49039625 @default.
• W2119906557 hasConcept C53227056 @default.
• W2119906557 hasConcept C55493867 @default.
• W2119906557 hasConcept C555293320 @default.
• W2119906557 hasConcept C71315377 @default.
• W2119906557 hasConcept C71924100 @default.
• W2119906557 hasConcept C86803240 @default.
• W2119906557 hasConceptScore W2119906557C103395026 @default.
• W2119906557 hasConceptScore W2119906557C126322002 @default.
• W2119906557 hasConceptScore W2119906557C134018914 @default.
• W2119906557 hasConceptScore W2119906557C1491633281 @default.
• W2119906557 hasConceptScore W2119906557C2776398474 @default.
• W2119906557 hasConceptScore W2119906557C2777180221 @default.
• W2119906557 hasConceptScore W2119906557C2777391703 @default.
• W2119906557 hasConceptScore W2119906557C2778881409 @default.
• W2119906557 hasConceptScore W2119906557C2779306644 @default.
• W2119906557 hasConceptScore W2119906557C2780401358 @default.
• W2119906557 hasConceptScore W2119906557C2780841215 @default.
• W2119906557 hasConceptScore W2119906557C46699223 @default.
• W2119906557 hasConceptScore W2119906557C49039625 @default.

• next