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- W2119910004 abstract "Significance The high-density packaging of DNA in many viruses is a process that requires the action of powerful molecular motor complexes. Besides being a key step in viral assembly, DNA packaging is a general model for understanding the physics of tightly confined polymers. A fundamental question raised in the literature is whether packaging can be modeled as a quasistatic thermodynamic process, in which the DNA relaxes quickly to equilibrium, or whether it involves nonequilibrium dynamics. In this study, we show that the confined DNA undergoes nonequilibrium dynamics with an extremely long relaxation time and this slows the motor, causes significant heterogeneity in packaging rates of individual viruses, and causes frequent pausing in DNA translocation by the motor." @default.
- W2119910004 created "2016-06-24" @default.
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- W2119910004 date "2014-05-27" @default.
- W2119910004 modified "2023-10-16" @default.
- W2119910004 title "Nonequilibrium dynamics and ultraslow relaxation of confined DNA during viral packaging" @default.
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- W2119910004 doi "https://doi.org/10.1073/pnas.1405109111" @default.
- W2119910004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4060647" @default.
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