Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119931361> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2119931361 endingPage "52" @default.
- W2119931361 startingPage "46" @default.
- W2119931361 abstract "Proliferative vascular lesions of the heart were found in mice exposed chronically to 1,3-butadiene by inhalation with an overall incidence of 30% in males and 43% in females. Based on histological criteria, the lesions were subclassified as endothelial hyperplasia with an incidence of 7% in males and 13% in females and hemangiosarcoma with an incidence of 23% and 30%, respectively. A dose-relationship for both lesions was observed in females, but not in males. The absence of a dose response in males was most likely due to the lower survival rate for high-dose animals (14%) when compared to the lower-dose animals (22%). Endothelial hyperplasia was characterized by widened vascular spaces lined by a single layer of plump endothelial cells. When cellular pleomorphism and piling up of endothelial nuclei were observed the lesion was diagnosed as hemangiosarcoma. Ultrastructural examination of hemangiosarcomas revealed lumen formation, intercellular junctions and cytoplasmic filaments. Pinocytotic vesicles which are 1 of the characteristics of endothelial cells could not be identified with certainty. Weibel-Palade bodies were not detected in the neoplastic endothelium. Metastatic lesions were observed in liver, lung and kidney. To date, 1,3-butadiene is the only carcinogen reported that induces proliferative vascular lesions in the heart of mice." @default.
- W2119931361 created "2016-06-24" @default.
- W2119931361 creator A5006308140 @default.
- W2119931361 creator A5015189447 @default.
- W2119931361 creator A5052670791 @default.
- W2119931361 creator A5073137170 @default.
- W2119931361 date "1988-01-01" @default.
- W2119931361 modified "2023-09-27" @default.
- W2119931361 title "Primary Cardiac Hemangiosarcomas Induced by 1,3-Butadiene in B6C3F1 Hybrid Mice" @default.
- W2119931361 cites W171476770 @default.
- W2119931361 cites W1982765102 @default.
- W2119931361 cites W2004286331 @default.
- W2119931361 cites W2028241170 @default.
- W2119931361 cites W2051679924 @default.
- W2119931361 cites W2073623140 @default.
- W2119931361 cites W2152243544 @default.
- W2119931361 doi "https://doi.org/10.1177/019262338801600106" @default.
- W2119931361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3375747" @default.
- W2119931361 hasPublicationYear "1988" @default.
- W2119931361 type Work @default.
- W2119931361 sameAs 2119931361 @default.
- W2119931361 citedByCount "14" @default.
- W2119931361 countsByYear W21199313612013 @default.
- W2119931361 countsByYear W21199313612016 @default.
- W2119931361 countsByYear W21199313612017 @default.
- W2119931361 countsByYear W21199313612019 @default.
- W2119931361 crossrefType "journal-article" @default.
- W2119931361 hasAuthorship W2119931361A5006308140 @default.
- W2119931361 hasAuthorship W2119931361A5015189447 @default.
- W2119931361 hasAuthorship W2119931361A5052670791 @default.
- W2119931361 hasAuthorship W2119931361A5073137170 @default.
- W2119931361 hasConcept C123012128 @default.
- W2119931361 hasConcept C126322002 @default.
- W2119931361 hasConcept C131631996 @default.
- W2119931361 hasConcept C134018914 @default.
- W2119931361 hasConcept C142724271 @default.
- W2119931361 hasConcept C202751555 @default.
- W2119931361 hasConcept C2776992346 @default.
- W2119931361 hasConcept C2777562237 @default.
- W2119931361 hasConcept C2779217266 @default.
- W2119931361 hasConcept C2781082889 @default.
- W2119931361 hasConcept C55493867 @default.
- W2119931361 hasConcept C71924100 @default.
- W2119931361 hasConcept C86803240 @default.
- W2119931361 hasConceptScore W2119931361C123012128 @default.
- W2119931361 hasConceptScore W2119931361C126322002 @default.
- W2119931361 hasConceptScore W2119931361C131631996 @default.
- W2119931361 hasConceptScore W2119931361C134018914 @default.
- W2119931361 hasConceptScore W2119931361C142724271 @default.
- W2119931361 hasConceptScore W2119931361C202751555 @default.
- W2119931361 hasConceptScore W2119931361C2776992346 @default.
- W2119931361 hasConceptScore W2119931361C2777562237 @default.
- W2119931361 hasConceptScore W2119931361C2779217266 @default.
- W2119931361 hasConceptScore W2119931361C2781082889 @default.
- W2119931361 hasConceptScore W2119931361C55493867 @default.
- W2119931361 hasConceptScore W2119931361C71924100 @default.
- W2119931361 hasConceptScore W2119931361C86803240 @default.
- W2119931361 hasIssue "1" @default.
- W2119931361 hasLocation W21199313611 @default.
- W2119931361 hasLocation W21199313612 @default.
- W2119931361 hasOpenAccess W2119931361 @default.
- W2119931361 hasPrimaryLocation W21199313611 @default.
- W2119931361 hasRelatedWork W1246004351 @default.
- W2119931361 hasRelatedWork W1892146161 @default.
- W2119931361 hasRelatedWork W1930941909 @default.
- W2119931361 hasRelatedWork W2020733013 @default.
- W2119931361 hasRelatedWork W2085115310 @default.
- W2119931361 hasRelatedWork W2092212153 @default.
- W2119931361 hasRelatedWork W2148756102 @default.
- W2119931361 hasRelatedWork W2348730634 @default.
- W2119931361 hasRelatedWork W2357572431 @default.
- W2119931361 hasRelatedWork W2371388415 @default.
- W2119931361 hasVolume "16" @default.
- W2119931361 isParatext "false" @default.
- W2119931361 isRetracted "false" @default.
- W2119931361 magId "2119931361" @default.
- W2119931361 workType "article" @default.