FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119933271> ?p ?o ?g. }

• W2119933271 abstract "CAPE, one of the most active compounds in propolis, is the perfect illustration of a natural compound exhibiting diverse biological activities. However, rapid decomposition by esterase leads to its low bioavailability in vivo. The aim of the present study is to synthesis and investigates the antioxidant and protective activities of novel derivative of caffeic acid, CAMBA against STZ-induced diabetic complications in diabetic rats. Since amide is more resistant to esterase enzyme. CAMBA was synthesized by reacting the amino group of methyl anthranilate with caffeic acid in the presence of PCl 3 . Diabetic rats was induced by injection of STZ (55 mg/kg, i.p.) and diabetes was confirmed 48 h after induction, and then allowed for 7 days to stabilize blood glucose level. CAMBA (25 and 50 mg/kg b.w daily for 28 days) treated diabetic rats significantly reduced elevated blood glucose, TC, TG, atherogenic index, LDL-c, vLDL-c, hepatic, renal and cardiac TBARs and HP. The treatment also resulted in improved the insulin and insulin resistance and significantly increased serumHDL-c and GSH, SOD, CAT and GPx in the liver, kidney and heart of diabetic rats. The results clearly suggest that CAMBA treated group may effectively normalize the impaired antioxidant status in streptozotocin induced diabetes than the glibenclamide-treated groups. CAMBA exerted rapid protective effects against lipid peroxidation by scavenging of free radicals by reducing the risk of diabetic complications. Taken together, CAMBA has potential as an antioxidant agent for diabetes and deserves clinical trial in the near future as an adjuvant therapy in diabetic patients" @default.
• W2119933271 created "2016-06-24" @default.
• W2119933271 creator A5064652037 @default.
• W2119933271 date "2013-01-01" @default.
• W2119933271 modified "2023-09-30" @default.
• W2119933271 title "CAMBA, a New Synthesized and Promising Protector against STZ-Induced Diabetic Complications in Rats" @default.
• W2119933271 cites W106107227 @default.
• W2119933271 cites W1599342152 @default.
• W2119933271 cites W1771441866 @default.
• W2119933271 cites W1775749144 @default.
• W2119933271 cites W1920653771 @default.
• W2119933271 cites W1946263363 @default.
• W2119933271 cites W1969047006 @default.
• W2119933271 cites W1976191764 @default.
• W2119933271 cites W1984642803 @default.
• W2119933271 cites W1985733683 @default.
• W2119933271 cites W1993506825 @default.
• W2119933271 cites W1995382021 @default.
• W2119933271 cites W1995533037 @default.
• W2119933271 cites W1998627784 @default.
• W2119933271 cites W2006370393 @default.
• W2119933271 cites W2006853439 @default.
• W2119933271 cites W2019778386 @default.
• W2119933271 cites W2021341118 @default.
• W2119933271 cites W2022271344 @default.
• W2119933271 cites W2024636345 @default.
• W2119933271 cites W2035576567 @default.
• W2119933271 cites W2040653574 @default.
• W2119933271 cites W2043498277 @default.
• W2119933271 cites W2055780054 @default.
• W2119933271 cites W2057522312 @default.
• W2119933271 cites W2057698030 @default.
• W2119933271 cites W2060194897 @default.
• W2119933271 cites W2061333433 @default.
• W2119933271 cites W2070245925 @default.
• W2119933271 cites W2080355327 @default.
• W2119933271 cites W2085502292 @default.
• W2119933271 cites W2088012387 @default.
• W2119933271 cites W2096795975 @default.
• W2119933271 cites W2101518804 @default.
• W2119933271 cites W2108250096 @default.
• W2119933271 cites W2112790234 @default.
• W2119933271 cites W2113421153 @default.
• W2119933271 cites W2115100047 @default.
• W2119933271 cites W2116404316 @default.
• W2119933271 cites W2116688308 @default.
• W2119933271 cites W2130814871 @default.
• W2119933271 cites W2151716122 @default.
• W2119933271 cites W2152919855 @default.
• W2119933271 cites W2154774609 @default.
• W2119933271 cites W2159611626 @default.
• W2119933271 cites W2160234571 @default.
• W2119933271 cites W2163227283 @default.
• W2119933271 cites W2167543749 @default.
• W2119933271 cites W2325058373 @default.
• W2119933271 cites W2407240037 @default.
• W2119933271 cites W2419397704 @default.
• W2119933271 cites W2473955337 @default.
• W2119933271 cites W2496629516 @default.
• W2119933271 cites W208459642 @default.
• W2119933271 cites W2187975915 @default.
• W2119933271 doi "https://doi.org/10.4172/2161-0444.1000153" @default.
• W2119933271 hasPublicationYear "2013" @default.
• W2119933271 type Work @default.
• W2119933271 sameAs 2119933271 @default.
• W2119933271 citedByCount "2" @default.
• W2119933271 countsByYear W21199332712021 @default.
• W2119933271 crossrefType "journal-article" @default.
• W2119933271 hasAuthorship W2119933271A5064652037 @default.
• W2119933271 hasBestOaLocation W21199332711 @default.
• W2119933271 hasConcept C126322002 @default.
• W2119933271 hasConcept C134018914 @default.
• W2119933271 hasConcept C185592680 @default.
• W2119933271 hasConcept C2777352226 @default.
• W2119933271 hasConcept C2777391703 @default.
• W2119933271 hasConcept C2778004101 @default.
• W2119933271 hasConcept C2778224086 @default.
• W2119933271 hasConcept C2779280383 @default.
• W2119933271 hasConcept C2779306644 @default.
• W2119933271 hasConcept C2779768347 @default.
• W2119933271 hasConcept C2779922275 @default.
• W2119933271 hasConcept C2780829032 @default.
• W2119933271 hasConcept C55493867 @default.
• W2119933271 hasConcept C555293320 @default.
• W2119933271 hasConcept C71924100 @default.
• W2119933271 hasConcept C98274493 @default.
• W2119933271 hasConceptScore W2119933271C126322002 @default.
• W2119933271 hasConceptScore W2119933271C134018914 @default.
• W2119933271 hasConceptScore W2119933271C185592680 @default.
• W2119933271 hasConceptScore W2119933271C2777352226 @default.
• W2119933271 hasConceptScore W2119933271C2777391703 @default.
• W2119933271 hasConceptScore W2119933271C2778004101 @default.
• W2119933271 hasConceptScore W2119933271C2778224086 @default.
• W2119933271 hasConceptScore W2119933271C2779280383 @default.
• W2119933271 hasConceptScore W2119933271C2779306644 @default.
• W2119933271 hasConceptScore W2119933271C2779768347 @default.
• W2119933271 hasConceptScore W2119933271C2779922275 @default.
• W2119933271 hasConceptScore W2119933271C2780829032 @default.
• W2119933271 hasConceptScore W2119933271C55493867 @default.
• W2119933271 hasConceptScore W2119933271C555293320 @default.

• next