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• W2119945057 endingPage "H440" @default.
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• W2119945057 abstract "We have reported that eucapnic intermittent hypoxia (E-IH) causes systemic hypertension, elevates plasma endothelin 1 (ET-1) levels, and augments vascular reactivity to ET-1 and that a nonspecific ET-1 receptor antagonist acutely lowers blood pressure in E-IH-exposed rats. However, the effect of chronic ET-1 receptor inhibition has not been evaluated, and the ET receptor subtype mediating the vascular effects has not been established. We hypothesized that E-IH causes systemic hypertension through the increased ET-1 activation of vascular ET type A (ET A ) receptors. We found that mean arterial pressure (MAP) increased after 14 days of 7 h/day E-IH exposure (109 ± 2 to 137 ± 4 mmHg; P < 0.005) but did not change in sham-exposed rats. The ET A receptor antagonist BQ-123 (10 to 1,000 nmol/kg iv) acutely decreased MAP dose dependently in conscious E-IH but not sham rats, and continuous infusion of BQ-123 (100 nmol·kg −1 ·day −1 sc for 14 days) prevented E-IH-induced increases in MAP. ET-1-induced constriction was augmented in small mesenteric arteries from rats exposed 14 days to E-IH compared with those from sham rats. Constriction was blocked by the ET A receptor antagonist BQ-123 (10 μM) but not by the ET type B (ET B ) receptor antagonist BQ-788 (100 μM). ET A receptor mRNA content was greater in renal medulla and coronary arteries from E-IH rats. ET B receptor mRNA was not different in any tissues examined, whereas ET-1 mRNA was increased in the heart and in the renal medulla. Thus augmented ET-1-dependent vasoconstriction via vascular ET A receptors appears to elevate blood pressure in E-IH-exposed rats." @default.
• W2119945057 created "2016-06-24" @default.
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• W2119945057 date "2008-07-01" @default.
• W2119945057 modified "2023-09-27" @default.
• W2119945057 title "Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia" @default.
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• W2119945057 doi "https://doi.org/10.1152/ajpheart.91477.2007" @default.
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