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- W2119958765 abstract "The AFTherapy study1 represents an ambitious project with the intention to settle a number of questions about pacemaker programming to prevent the start of atrial fibrillation (AF). This controversial but also promising and insufficiently understood non-pharmacological therapy of AF raises a number of questions.The first question concerns the ideal pacing rate. An individualized pacing rate of 10 bpm faster than the average intrinsic heart rate (taken from pacemaker memory2), a pacing rate 20% faster than the intrinsic rate,3 and a rate 10–19% faster than the average intrinsic sinus rate (in atrial single-chamber pacing4) have been reported to successfully prevent AF. In contrast, the PA3 trials showed no difference between pacing at a (non-individualized) rate of 30 and 70 bpm.5The second question concerns the use of rate-adaptive pacing. Bellocci et al .6 reported that in patients with chronotropic sinus node incompetence, pacing in the rate-adaptive mode was superior in suppressing AF than the DDD mode. However, this has never been reproduced.Finally, an AF-suppressive effect of pacing has been reported to require atrial stimulation during sinus rhythm for >80 or 90% of the time.7,8 This is best achieved by overdrive pacing algorithms that pace the heart dynamically just above the intrinsic rate. Similarly, Murgatroyd et al .9 found an antiarrhythmic effect of a pacing algorithm that prevented short–long cycles after atrial premature beats (APBs). … *Corresponding author. Tel: +49 69 6301 5579; fax: +49 69 6301 3813. E-mail address : c.w.israel{at}em.uni-frankfurt.de" @default.
- W2119958765 created "2016-06-24" @default.
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- W2119958765 date "2007-10-03" @default.
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- W2119958765 title "Studying atrial fibrillation: what can we learn from the AFTherapy study?" @default.
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- W2119958765 doi "https://doi.org/10.1093/europace/eum254" @default.
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