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• W2119960010 abstract "Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity for glycolytic glucose processing in astrocytes compared to neurons. Methylglyoxal, a highly reactive dicarbonyl compound, is inevitably formed as a by-product of glycolysis. Methylglyoxal is a major cell-permeant precursor of advanced glycation end-products (AGEs), which are associated with several pathologies including diabetes, aging and neurodegenerative diseases. The glyoxalase system is the most important pathway for the detoxification of methylglyoxal, and although the neurotoxic effects of methylglyoxal and AGEs are well characterized, less is known about the glyoxalase system in the brain. Considering the high energy requirements (i.e. glucose) of the brain, one should expect that the cerebral glyoxalase system is adequately fitted to handle methylglyoxal toxicity. This review focuses on our actual knowledge on the cellular aspects of the glyoxalase system in brain cells, in particular with regards to its activity in astrocytes and neurons. A main emerging concept is that a neuroenergetic specialization is taking place between these two cell types which may serve as a protective mechanism against methylglyoxal-induced toxicity." @default.
• W2119960010 created "2016-06-24" @default.
• W2119960010 creator A5019558455 @default.
• W2119960010 creator A5037451153 @default.
• W2119960010 creator A5061978582 @default.
• W2119960010 date "2015-02-09" @default.
• W2119960010 modified "2023-10-01" @default.
• W2119960010 title "Methylglyoxal, the dark side of glycolysis" @default.
• W2119960010 cites W120247693 @default.
• W2119960010 cites W1487835906 @default.
• W2119960010 cites W1823461212 @default.
• W2119960010 cites W1858755391 @default.
• W2119960010 cites W1906005106 @default.
• W2119960010 cites W1914653694 @default.
• W2119960010 cites W1952806621 @default.
• W2119960010 cites W1964343416 @default.
• W2119960010 cites W1965236376 @default.
• W2119960010 cites W1968051733 @default.
• W2119960010 cites W1969653601 @default.
• W2119960010 cites W1970789531 @default.
• W2119960010 cites W1970836174 @default.
• W2119960010 cites W1971395059 @default.
• W2119960010 cites W1973924126 @default.
• W2119960010 cites W1974420316 @default.
• W2119960010 cites W1975262997 @default.
• W2119960010 cites W1975533740 @default.
• W2119960010 cites W1980189058 @default.
• W2119960010 cites W1981319871 @default.
• W2119960010 cites W1981846387 @default.
• W2119960010 cites W1984929731 @default.
• W2119960010 cites W1985994475 @default.
• W2119960010 cites W1987236767 @default.
• W2119960010 cites W1989687638 @default.
• W2119960010 cites W1990158364 @default.
• W2119960010 cites W2000782226 @default.
• W2119960010 cites W2000867410 @default.
• W2119960010 cites W2002263665 @default.
• W2119960010 cites W2004586101 @default.
• W2119960010 cites W2004629434 @default.
• W2119960010 cites W2005925597 @default.
• W2119960010 cites W2009966509 @default.
• W2119960010 cites W2012601853 @default.
• W2119960010 cites W2013765317 @default.
• W2119960010 cites W2015092638 @default.
• W2119960010 cites W2016927879 @default.
• W2119960010 cites W2019078591 @default.
• W2119960010 cites W2022660408 @default.
• W2119960010 cites W2022908550 @default.
• W2119960010 cites W2026131755 @default.
• W2119960010 cites W2027054607 @default.
• W2119960010 cites W2027068697 @default.
• W2119960010 cites W2029686023 @default.
• W2119960010 cites W2032163981 @default.
• W2119960010 cites W2036829402 @default.
• W2119960010 cites W2036891300 @default.
• W2119960010 cites W2037140288 @default.
• W2119960010 cites W2038350512 @default.
• W2119960010 cites W2038774327 @default.
• W2119960010 cites W2041658170 @default.
• W2119960010 cites W2041874445 @default.
• W2119960010 cites W2043406394 @default.
• W2119960010 cites W2043946608 @default.
• W2119960010 cites W2044108809 @default.
• W2119960010 cites W2045689259 @default.
• W2119960010 cites W2047546483 @default.
• W2119960010 cites W2048360724 @default.
• W2119960010 cites W2052644645 @default.
• W2119960010 cites W2054275187 @default.
• W2119960010 cites W2056964101 @default.
• W2119960010 cites W2058961641 @default.
• W2119960010 cites W2059681268 @default.
• W2119960010 cites W2061204921 @default.
• W2119960010 cites W2062977811 @default.
• W2119960010 cites W2069987358 @default.
• W2119960010 cites W2072548440 @default.
• W2119960010 cites W2072756170 @default.
• W2119960010 cites W2076619655 @default.
• W2119960010 cites W2077319761 @default.
• W2119960010 cites W2080529335 @default.
• W2119960010 cites W2081269531 @default.
• W2119960010 cites W2083252150 @default.
• W2119960010 cites W2086899835 @default.
• W2119960010 cites W2092045636 @default.
• W2119960010 cites W2092635505 @default.
• W2119960010 cites W2092969356 @default.
• W2119960010 cites W2093439345 @default.
• W2119960010 cites W2094633691 @default.
• W2119960010 cites W2094784513 @default.
• W2119960010 cites W2095203090 @default.
• W2119960010 cites W2096066003 @default.
• W2119960010 cites W2098685543 @default.
• W2119960010 cites W2102697857 @default.
• W2119960010 cites W2108762011 @default.
• W2119960010 cites W2111261869 @default.
• W2119960010 cites W2113429577 @default.
• W2119960010 cites W2116641094 @default.
• W2119960010 cites W2116845452 @default.
• W2119960010 cites W2119255682 @default.
• W2119960010 cites W2123716968 @default.
• W2119960010 cites W2124940469 @default.

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