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• W2119961969 abstract "Spin-labeling studies of membrane-contaminant interaction are being conducted by biochemists at the Northwest Fisheries Center in Seattle, Washington. The aim of these studies is to gain a better understanding of the mode of action of hydrocarbon contaminants at the molecular level. Basic spin-labeling theory together with experimental results are presented and discussed. Spin-labeling holds great promise not only for environmental studies but also for drug research, toxicology, and pharmacology as well. The interaction between contaminants and living systems commences when contaminants combine with so-called active sites in living tissue. Active sites are varied in nature, but often they are groups of molecules assembled in a special fashion such as those which comprise membranes and as­ sociated enzymes or other biopolymers. Although the exact nature of contaminant-host interaction may not be known in each and every case, experimental data from biochemical/bio­ physical studies allow us to draw certain conclusions about interactions. With detailed investigations, collected data may even allow us to draw a fairly accurate picture concerning the molecular basis of physiological changes which contaminants are able to induce. Admittedly, investigations such as these are difficult to perform. The molecular complexity of living systems defies ready characterization, and it is even more difficult to relate alterations in molecular organization to the subsequent physiological changes wrought by this con­ taminant-host interaction. Recent years have seen an upsurge of interest in membranes and how membrane structure is modified when invaded by such things as drugs and insecticides. The reasons are several: membranes house cells, control the influx and efflux of nutrients and metabolites; membranes" @default.
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• W2119961969 date "1975-04-01" @default.
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• W2119961969 title "SPIN-LABELING TECHNIQUES FOR STUDYING MODE OF ACTION OF PETROLEUM HYDROCARBONS ON MARINE ORGANISMS" @default.
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