FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120013569> ?p ?o ?g. }

• W2120013569 endingPage "330" @default.
• W2120013569 startingPage "322" @default.
• W2120013569 abstract "Translational inhibitors such as the trichothecene mycotoxin deoxynivalenol (DON) and ribosomal inhibitory proteins (RIPs) induce mitogen-activated protein kinase (MAPK)–driven chemokine and cytokine production by a mechanism known as the ribotoxic stress response (RSR). Double-stranded RNA–activated protein kinase (PKR) associates with the ribosome making it uniquely positioned to sense 28S ribosomal RNA damage and initiate the RSR. We have previously shown that PKR mediates DON-induced MAPK phosphorylation in macrophages and monocytes. The purpose of this study was to test the hypothesis that PKR is essential for induction of interleukin (IL)-8 expression in monocytes by DON and two prototypical RIPs, ricin, and Shiga toxin 1 (Stx1). Preincubation of human monocytic U937 cells with the PKR inhibitors C16 and 2-aminopurine (2-AP) blocked DON-induced expression of IL-8 protein and mRNA. Induction of IL-8 expression was similarly impaired in U937 cells stably transfected with a dominant negative PKR plasmid (UK9M) as compared with cells transfected with control plasmid (UK9C). Nuclear factor-kappa B binding, which has been previously shown to be a requisite for DON-induced IL-8 transcription, was markedly reduced in UK9M cells as compared with UK9C cells. As observed for DON, ricin-, and Stx1–induced IL-8 expression was suppressed by the PKR inhibitors C16 and 2-AP as well as impaired in UK9M cells. Taken together, these data indicate that PKR plays a common role in IL-8 induction by DON and the two RIPs, suggesting that this kinase might be a critical factor in RSR." @default.
• W2120013569 created "2016-06-24" @default.
• W2120013569 creator A5048823930 @default.
• W2120013569 creator A5060677752 @default.
• W2120013569 creator A5069829237 @default.
• W2120013569 creator A5073293066 @default.
• W2120013569 creator A5087322853 @default.
• W2120013569 date "2008-07-28" @default.
• W2120013569 modified "2023-10-14" @default.
• W2120013569 title "Double-Stranded RNA–Activated Protein Kinase Mediates Induction of Interleukin-8 Expression by Deoxynivalenol, Shiga Toxin 1, and Ricin in Monocytes" @default.
• W2120013569 cites W1504003784 @default.
• W2120013569 cites W1602538488 @default.
• W2120013569 cites W1907128661 @default.
• W2120013569 cites W1967333602 @default.
• W2120013569 cites W1975295728 @default.
• W2120013569 cites W1983310769 @default.
• W2120013569 cites W1984034531 @default.
• W2120013569 cites W1984364760 @default.
• W2120013569 cites W1986038921 @default.
• W2120013569 cites W1986134620 @default.
• W2120013569 cites W1986973183 @default.
• W2120013569 cites W1993250698 @default.
• W2120013569 cites W1994601555 @default.
• W2120013569 cites W1995874940 @default.
• W2120013569 cites W1998798221 @default.
• W2120013569 cites W2007245385 @default.
• W2120013569 cites W2014802742 @default.
• W2120013569 cites W2018700855 @default.
• W2120013569 cites W2023831963 @default.
• W2120013569 cites W2026494458 @default.
• W2120013569 cites W2027422803 @default.
• W2120013569 cites W2029575231 @default.
• W2120013569 cites W2031116438 @default.
• W2120013569 cites W2031495829 @default.
• W2120013569 cites W2035477349 @default.
• W2120013569 cites W2035737192 @default.
• W2120013569 cites W2036398018 @default.
• W2120013569 cites W2037087465 @default.
• W2120013569 cites W2062626858 @default.
• W2120013569 cites W2071609648 @default.
• W2120013569 cites W2076011104 @default.
• W2120013569 cites W2086855617 @default.
• W2120013569 cites W2093480401 @default.
• W2120013569 cites W2096786196 @default.
• W2120013569 cites W2100316337 @default.
• W2120013569 cites W2100875904 @default.
• W2120013569 cites W2107782714 @default.
• W2120013569 cites W2108736984 @default.
• W2120013569 cites W2111025555 @default.
• W2120013569 cites W2111304767 @default.
• W2120013569 cites W2112417442 @default.
• W2120013569 cites W2119928295 @default.
• W2120013569 cites W2122033270 @default.
• W2120013569 cites W2129232900 @default.
• W2120013569 cites W2133764756 @default.
• W2120013569 cites W2140796894 @default.
• W2120013569 cites W2149540111 @default.
• W2120013569 cites W2159648100 @default.
• W2120013569 cites W2162711679 @default.
• W2120013569 cites W2062850550 @default.
• W2120013569 doi "https://doi.org/10.1093/toxsci/kfn128" @default.
• W2120013569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2721672" @default.
• W2120013569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18599499" @default.
• W2120013569 hasPublicationYear "2008" @default.
• W2120013569 type Work @default.
• W2120013569 sameAs 2120013569 @default.
• W2120013569 citedByCount "52" @default.
• W2120013569 countsByYear W21200135692012 @default.
• W2120013569 countsByYear W21200135692013 @default.
• W2120013569 countsByYear W21200135692014 @default.
• W2120013569 countsByYear W21200135692015 @default.
• W2120013569 countsByYear W21200135692016 @default.
• W2120013569 countsByYear W21200135692017 @default.
• W2120013569 countsByYear W21200135692018 @default.
• W2120013569 countsByYear W21200135692019 @default.
• W2120013569 countsByYear W21200135692021 @default.
• W2120013569 countsByYear W21200135692022 @default.
• W2120013569 countsByYear W21200135692023 @default.
• W2120013569 crossrefType "journal-article" @default.
• W2120013569 hasAuthorship W2120013569A5048823930 @default.
• W2120013569 hasAuthorship W2120013569A5060677752 @default.
• W2120013569 hasAuthorship W2120013569A5069829237 @default.
• W2120013569 hasAuthorship W2120013569A5073293066 @default.
• W2120013569 hasAuthorship W2120013569A5087322853 @default.
• W2120013569 hasBestOaLocation W21200135691 @default.
• W2120013569 hasConcept C104317684 @default.
• W2120013569 hasConcept C153911025 @default.
• W2120013569 hasConcept C161238802 @default.
• W2120013569 hasConcept C184235292 @default.
• W2120013569 hasConcept C2777200438 @default.
• W2120013569 hasConcept C2777367657 @default.
• W2120013569 hasConcept C2777479484 @default.
• W2120013569 hasConcept C3675279 @default.
• W2120013569 hasConcept C54009773 @default.
• W2120013569 hasConcept C55493867 @default.
• W2120013569 hasConcept C67705224 @default.
• W2120013569 hasConcept C82495950 @default.
• W2120013569 hasConcept C86803240 @default.

• next