FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120061907> ?p ?o ?g. }

• W2120061907 abstract "Hepatocellular carcinoma is the fifth most common neoplasm and the most important cause of death in patients with liver cirrhosis in the world. lipopolysaccharide (LPS) stimulates the hepatocyte cells and increases the production of inducible cytokine with the high production of nitric oxide and ROS. Chronic inflammation caused by lipopolysaccharide directly activates immune system and indirectly, through COX-2 interferes in the formation of malignant disease. In this study, the rate change of COX-2 was searched by adding LPS and also the effect of inhibition of this inflammatory enzyme by Celecoxib and combined effect of this in HepG2 cancer cells was assessed. Salmonellaenteritidis lipopolysaccharide is extracted by methanol-chloroform method and the Sodium dodesyl sulfate poly acryl-amide gel electrophoresis (SDS-PAGE) electrophoresis bands were stained by silver nitrate. Four treatment groups of HepG2 cells were stimulated with 100 ng/ml LPS, 500 µM Celecoxib as inhibitor and were incubated for 12 and 24 h. Variables including both increase and decrease inflammatory factor, COX-2, was assayed. The obtained results showed that initial activity of COX-2 in not stimulated in HepG2 cell, 1.957 ng/ml after stimulation  with LPS for 12 and 24 h (1.383 and 0.618 ng/ml) decreased and the effect of this inhibitor was also studied. The data showed that the reduction of COX-2 in HepG2 cells was correlated with the cell density and duration of incubation with LPS. Inhibition of enzyme associated with inflammation, with inhibitor substance; celecoxib, observed as well as LPS. We can potentially design drugs to treat a variety of diseases and cancers. Key words: Cyclooxygenase-2, HepG2 Cell, Salmonella enteritidis,lipopolysaccharide, Sodium dodesyl sulfate poly acryl-amide gel electrophoresis (SDS-PAGE)." @default.
• W2120061907 created "2016-06-24" @default.
• W2120061907 creator A5068395866 @default.
• W2120061907 date "2011-11-16" @default.
• W2120061907 modified "2023-09-26" @default.
• W2120061907 title "The effect of extracted bacterial LPS from Salmonella enteritidis on COX-2 in hepg2 cell line in induction and inhibition conditions" @default.
• W2120061907 cites W1753891167 @default.
• W2120061907 cites W1971041045 @default.
• W2120061907 cites W1987797584 @default.
• W2120061907 cites W2003951344 @default.
• W2120061907 cites W2010682360 @default.
• W2120061907 cites W2017969259 @default.
• W2120061907 cites W2026403400 @default.
• W2120061907 cites W2030027307 @default.
• W2120061907 cites W2040380614 @default.
• W2120061907 cites W2045195614 @default.
• W2120061907 cites W2048699584 @default.
• W2120061907 cites W2059080581 @default.
• W2120061907 cites W2069465836 @default.
• W2120061907 cites W2093595670 @default.
• W2120061907 cites W2094433183 @default.
• W2120061907 cites W2105372476 @default.
• W2120061907 cites W2110283088 @default.
• W2120061907 cites W2113324284 @default.
• W2120061907 cites W2117580825 @default.
• W2120061907 cites W2133644846 @default.
• W2120061907 cites W2145894904 @default.
• W2120061907 cites W2149789821 @default.
• W2120061907 cites W2172176302 @default.
• W2120061907 cites W2173405796 @default.
• W2120061907 cites W2508669736 @default.
• W2120061907 cites W311477833 @default.
• W2120061907 doi "https://doi.org/10.5897/sre11.991" @default.
• W2120061907 hasPublicationYear "2011" @default.
• W2120061907 type Work @default.
• W2120061907 sameAs 2120061907 @default.
• W2120061907 citedByCount "0" @default.
• W2120061907 crossrefType "journal-article" @default.
• W2120061907 hasAuthorship W2120061907A5068395866 @default.
• W2120061907 hasConcept C185592680 @default.
• W2120061907 hasConcept C198352243 @default.
• W2120061907 hasConcept C2524010 @default.
• W2120061907 hasConcept C2781065037 @default.
• W2120061907 hasConcept C2992956773 @default.
• W2120061907 hasConcept C33923547 @default.
• W2120061907 hasConcept C523546767 @default.
• W2120061907 hasConcept C54355233 @default.
• W2120061907 hasConcept C86803240 @default.
• W2120061907 hasConcept C89423630 @default.
• W2120061907 hasConceptScore W2120061907C185592680 @default.
• W2120061907 hasConceptScore W2120061907C198352243 @default.
• W2120061907 hasConceptScore W2120061907C2524010 @default.
• W2120061907 hasConceptScore W2120061907C2781065037 @default.
• W2120061907 hasConceptScore W2120061907C2992956773 @default.
• W2120061907 hasConceptScore W2120061907C33923547 @default.
• W2120061907 hasConceptScore W2120061907C523546767 @default.
• W2120061907 hasConceptScore W2120061907C54355233 @default.
• W2120061907 hasConceptScore W2120061907C86803240 @default.
• W2120061907 hasConceptScore W2120061907C89423630 @default.
• W2120061907 hasIssue "27" @default.
• W2120061907 hasLocation W21200619071 @default.
• W2120061907 hasOpenAccess W2120061907 @default.
• W2120061907 hasPrimaryLocation W21200619071 @default.
• W2120061907 hasRelatedWork W1990465409 @default.
• W2120061907 hasRelatedWork W2007247366 @default.
• W2120061907 hasRelatedWork W2083341468 @default.
• W2120061907 hasRelatedWork W2402580131 @default.
• W2120061907 hasRelatedWork W2623667421 @default.
• W2120061907 hasRelatedWork W2767270188 @default.
• W2120061907 hasRelatedWork W2790132051 @default.
• W2120061907 hasRelatedWork W3095052098 @default.
• W2120061907 hasRelatedWork W4242650965 @default.
• W2120061907 hasRelatedWork W611279721 @default.
• W2120061907 hasVolume "6" @default.
• W2120061907 isParatext "false" @default.
• W2120061907 isRetracted "false" @default.
• W2120061907 magId "2120061907" @default.
• W2120061907 workType "article" @default.