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- W2120068081 abstract "bir-1, a Caenorhabditis elegans inhibitor-of-apoptosis gene homologous to Survivin is organized in an operon with the transcription cofactor C. elegans SKIP (skp-1). Because genes arranged in operons are frequently linked functionally, we have asked whether BIR-1 also functions in transcription. bir-1 inhibition resulted in multiple developmental defects that overlapped with C. elegans SKIP loss-of-function phenotypes: retention of eggs, dumpy, movement defects, and lethality. bir-1 RNA-mediated interference decreased expression of several gfp transgenes and the endogenous genes dpy-7 and hlh-1. Immunoblot analysis revealed decreased phosphoacetylated histones in bir-1 RNA-mediated interference-treated worms. In a heterologous transfection system, BIR-1 augments thyroid hormone-regulated transcription and has an additive effect with SKIP. These results show that BIR-1 functions in the regulation of transcription and development." @default.
- W2120068081 created "2016-06-24" @default.
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- W2120068081 date "2003-04-07" @default.
- W2120068081 modified "2023-09-27" @default.
- W2120068081 title "BIR-1, a <i>Caenorhabditis elegans</i> homologue of Survivin, regulates transcription and development" @default.
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- W2120068081 doi "https://doi.org/10.1073/pnas.0730770100" @default.
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