FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120072015> ?p ?o ?g. }

• W2120072015 endingPage "F1696" @default.
• W2120072015 startingPage "F1689" @default.
• W2120072015 abstract "Cyclooxygenase-2 activity is required for the development of lithium-induced polyuria. However, the involvement of a specific, terminal prostaglandin (PG) isomerase has not been evaluated. The present study was undertaken to assess lithium-induced polyuria in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1). A 2-wk administration of LiCl (4 mmol·kg −1 ·day −1 ip) in mPGES-1 +/+ mice led to a marked polyuria with hyposmotic urine. This was associated with elevated renal mPGES-1 protein expression and increased urine PGE 2 excretion. In contrast, mPGES-1 −/− mice were largely resistant to lithium-induced polyuria and a urine concentrating defect, accompanied by nearly complete blockade of high urine PGE 2 and cAMP output. Immunoblotting, immunohistochemistry, and quantitative (q) RT-PCR consistently detected a significant decrease in aquaporin-2 (AQP2) protein expression in both the renal cortex and medulla of lithium-treated +/+ mice. This decrease was significantly attenuated in the −/− mice. qRT-PCR detected similar patterns of changes in AQP2 mRNA in the medulla but not in the cortex. Similarly, the total protein abundance of the Na-K-2Cl cotransporter (NKCC2) in the medulla but not in the cortex of the +/+ mice was significantly reduced by lithium treatment. In contrast, the dowregulation of renal medullary NKCC2 expression was significantly attenuated in the −/− mice. We conclude that mPGES-1-derived PGE 2 mediates lithium-induced polyuria likely via inhibition of AQP2 and NKCC2 expression." @default.
• W2120072015 created "2016-06-24" @default.
• W2120072015 creator A5035502209 @default.
• W2120072015 creator A5055615940 @default.
• W2120072015 creator A5068800226 @default.
• W2120072015 date "2009-12-01" @default.
• W2120072015 modified "2023-10-16" @default.
• W2120072015 title "Mice lacking mPGES-1 are resistant to lithium-induced polyuria" @default.
• W2120072015 cites W148860974 @default.
• W2120072015 cites W1521613920 @default.
• W2120072015 cites W160047280 @default.
• W2120072015 cites W1819269509 @default.
• W2120072015 cites W1968374401 @default.
• W2120072015 cites W1968946701 @default.
• W2120072015 cites W1974558855 @default.
• W2120072015 cites W1987518750 @default.
• W2120072015 cites W1998390912 @default.
• W2120072015 cites W2010743798 @default.
• W2120072015 cites W2011389860 @default.
• W2120072015 cites W2018779154 @default.
• W2120072015 cites W2020233709 @default.
• W2120072015 cites W2031414067 @default.
• W2120072015 cites W2035522549 @default.
• W2120072015 cites W2036357581 @default.
• W2120072015 cites W2041430298 @default.
• W2120072015 cites W2050586022 @default.
• W2120072015 cites W2052851574 @default.
• W2120072015 cites W2053755284 @default.
• W2120072015 cites W2057201827 @default.
• W2120072015 cites W2065520293 @default.
• W2120072015 cites W2070502223 @default.
• W2120072015 cites W2070609164 @default.
• W2120072015 cites W2072469560 @default.
• W2120072015 cites W2076510126 @default.
• W2120072015 cites W2078395115 @default.
• W2120072015 cites W2082414348 @default.
• W2120072015 cites W2084015052 @default.
• W2120072015 cites W2107172074 @default.
• W2120072015 cites W2114077097 @default.
• W2120072015 cites W2115150457 @default.
• W2120072015 cites W2117267381 @default.
• W2120072015 cites W2118955716 @default.
• W2120072015 cites W2119791966 @default.
• W2120072015 cites W2126816448 @default.
• W2120072015 cites W2127931326 @default.
• W2120072015 cites W2128629380 @default.
• W2120072015 cites W2129161450 @default.
• W2120072015 cites W2130846098 @default.
• W2120072015 cites W2133367977 @default.
• W2120072015 cites W2147451620 @default.
• W2120072015 cites W2147858025 @default.
• W2120072015 cites W2149791342 @default.
• W2120072015 cites W2150736343 @default.
• W2120072015 cites W2155913937 @default.
• W2120072015 cites W2156205428 @default.
• W2120072015 cites W2159973565 @default.
• W2120072015 cites W2161740453 @default.
• W2120072015 cites W2166629377 @default.
• W2120072015 cites W2169906890 @default.
• W2120072015 cites W2170671509 @default.
• W2120072015 cites W2171772418 @default.
• W2120072015 cites W2326791508 @default.
• W2120072015 cites W2402285594 @default.
• W2120072015 cites W2411907620 @default.
• W2120072015 cites W2417791538 @default.
• W2120072015 cites W4248590234 @default.
• W2120072015 cites W43291129 @default.
• W2120072015 doi "https://doi.org/10.1152/ajprenal.00117.2009" @default.
• W2120072015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2801334" @default.
• W2120072015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19692487" @default.
• W2120072015 hasPublicationYear "2009" @default.
• W2120072015 type Work @default.
• W2120072015 sameAs 2120072015 @default.
• W2120072015 citedByCount "32" @default.
• W2120072015 countsByYear W21200720152012 @default.
• W2120072015 countsByYear W21200720152013 @default.
• W2120072015 countsByYear W21200720152014 @default.
• W2120072015 countsByYear W21200720152015 @default.
• W2120072015 countsByYear W21200720152016 @default.
• W2120072015 countsByYear W21200720152017 @default.
• W2120072015 countsByYear W21200720152018 @default.
• W2120072015 countsByYear W21200720152019 @default.
• W2120072015 countsByYear W21200720152020 @default.
• W2120072015 countsByYear W21200720152022 @default.
• W2120072015 crossrefType "journal-article" @default.
• W2120072015 hasAuthorship W2120072015A5035502209 @default.
• W2120072015 hasAuthorship W2120072015A5055615940 @default.
• W2120072015 hasAuthorship W2120072015A5068800226 @default.
• W2120072015 hasBestOaLocation W21200720152 @default.
• W2120072015 hasConcept C126322002 @default.
• W2120072015 hasConcept C127413603 @default.
• W2120072015 hasConcept C134018914 @default.
• W2120072015 hasConcept C185592680 @default.
• W2120072015 hasConcept C201289731 @default.
• W2120072015 hasConcept C2775845273 @default.
• W2120072015 hasConcept C2777956040 @default.
• W2120072015 hasConcept C2778541603 @default.
• W2120072015 hasConcept C2778577996 @default.

• next