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- W2120085697 abstract "Abstract The influence of subclinical nematodosis on the kinetic disposition of albendazole was evaluated in goats following oral and intraruminal administration. The disposition curves of its metabolites indicated increased uptake of the drug in parasitized goats following intraruminal compared to oral dosing ( P < 0.05). The midpoint for the pharmacologically active metabolite, albendazole sulphoxide, in the circulatory compartment was around 0.6 μg ml − 1 both in parasitized and naïve goats. The period of exposure to this concentration was around 14 h (oral route), 18 h (intraruminal route) and 16 h (oral route), 17 h (intraruminal route) in parasitized and naïve goats, respectively. As the duration of exposure of parasites to the toxic concentration of the anthelmintically active metabolite was prolonged, it could be assumed that intraruminal delivery of the drug would improve the efficacy of albendazole in parasitized goats." @default.
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- W2120085697 date "2008-03-01" @default.
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- W2120085697 title "Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration" @default.
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- W2120085697 doi "https://doi.org/10.1017/s0022149x07870817" @default.
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