FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120097364> ?p ?o ?g. }

• W2120097364 endingPage "364" @default.
• W2120097364 startingPage "356" @default.
• W2120097364 abstract "Background. Morbidity and mortality from Pseudomonas aeruginosa sepsis remain high despite the availability of antibiotics to which the microorganism is sensitive. Methods. The in vitro activity of histatin derivative P-113d was investigated against Pseudomonas aeruginosa. In addition, its in vivo efficacy was studied in 3 rat models of infection: intraperitoneal injection of 1 mg of P. aeruginosa 10 lipopolysachharide, intraperitoneal injection of 2×1010 cfu of P. aeruginosa ATCC 27853, and intraabdominal sepsis induced by cecal ligation and puncture. Rats received isotonic sodium chloride solution parenterally (control groups), 1 mg of P-113d/kg of body weight, 1 mg of polymyxin B/kg of body weight, or 20 mg of imipenem/kg of body weight. Main outcomes measured were abdominal exudate and plasma bacterial growth, plasma concentrations of endotoxin and tumor necrosis factor (TNF)-α, and lethality. Results. The in vivo studies showed that all compounds reduced lethality, when compared with results forthe control group. Overall, P-113D exhibited a slightly lower antimicrobial activity than did imipenem, even thoughP-113d achieved a substantial decrease in plasma concentrations of endotoxin and TNF-α, compared with the imipenem. No statistically significant differences for antimicrobial and antiendotoxin activities were noted between P-113d and polymyxin B. Discussion. These results provide evidence for double antiendotoxin and antimicrobial activity for P-113d and point to its potential use for the treatment of severe infections." @default.
• W2120097364 created "2016-06-24" @default.
• W2120097364 creator A5009153069 @default.
• W2120097364 creator A5011531140 @default.
• W2120097364 creator A5032792725 @default.
• W2120097364 creator A5034315350 @default.
• W2120097364 creator A5043887609 @default.
• W2120097364 creator A5048127995 @default.
• W2120097364 creator A5062908020 @default.
• W2120097364 creator A5069140624 @default.
• W2120097364 creator A5076387912 @default.
• W2120097364 creator A5076696730 @default.
• W2120097364 creator A5080038571 @default.
• W2120097364 date "2004-07-15" @default.
• W2120097364 modified "2023-10-12" @default.
• W2120097364 title "Potential Therapeutic Role of Histatin Derivative P‐113<scp>d</scp>in Experimental Rat Models of<i>Pseudomonas aeruginosa</i>Sepsis" @default.
• W2120097364 cites W1505626160 @default.
• W2120097364 cites W1531531679 @default.
• W2120097364 cites W1543943621 @default.
• W2120097364 cites W167063456 @default.
• W2120097364 cites W194494035 @default.
• W2120097364 cites W1967628584 @default.
• W2120097364 cites W1975383446 @default.
• W2120097364 cites W1992755960 @default.
• W2120097364 cites W2002815984 @default.
• W2120097364 cites W2019566871 @default.
• W2120097364 cites W2021299645 @default.
• W2120097364 cites W2024437261 @default.
• W2120097364 cites W2031083926 @default.
• W2120097364 cites W2031250079 @default.
• W2120097364 cites W2037455416 @default.
• W2120097364 cites W2055429514 @default.
• W2120097364 cites W2061283656 @default.
• W2120097364 cites W2083563630 @default.
• W2120097364 cites W208372907 @default.
• W2120097364 cites W2085136523 @default.
• W2120097364 cites W2090888775 @default.
• W2120097364 cites W2096630634 @default.
• W2120097364 cites W2110313322 @default.
• W2120097364 cites W2120807334 @default.
• W2120097364 cites W2121105123 @default.
• W2120097364 cites W2128156980 @default.
• W2120097364 cites W2131192673 @default.
• W2120097364 cites W2131219772 @default.
• W2120097364 cites W2131443556 @default.
• W2120097364 cites W2138629986 @default.
• W2120097364 cites W2141380939 @default.
• W2120097364 cites W2145509829 @default.
• W2120097364 cites W2159729475 @default.
• W2120097364 cites W2161452784 @default.
• W2120097364 cites W2161781239 @default.
• W2120097364 cites W2169062060 @default.
• W2120097364 cites W2171951314 @default.
• W2120097364 cites W63034058 @default.
• W2120097364 doi "https://doi.org/10.1086/421913" @default.
• W2120097364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15216473" @default.
• W2120097364 hasPublicationYear "2004" @default.
• W2120097364 type Work @default.
• W2120097364 sameAs 2120097364 @default.
• W2120097364 citedByCount "23" @default.
• W2120097364 countsByYear W21200973642013 @default.
• W2120097364 countsByYear W21200973642015 @default.
• W2120097364 countsByYear W21200973642016 @default.
• W2120097364 countsByYear W21200973642017 @default.
• W2120097364 countsByYear W21200973642020 @default.
• W2120097364 countsByYear W21200973642021 @default.
• W2120097364 countsByYear W21200973642022 @default.
• W2120097364 countsByYear W21200973642023 @default.
• W2120097364 crossrefType "journal-article" @default.
• W2120097364 hasAuthorship W2120097364A5009153069 @default.
• W2120097364 hasAuthorship W2120097364A5011531140 @default.
• W2120097364 hasAuthorship W2120097364A5032792725 @default.
• W2120097364 hasAuthorship W2120097364A5034315350 @default.
• W2120097364 hasAuthorship W2120097364A5043887609 @default.
• W2120097364 hasAuthorship W2120097364A5048127995 @default.
• W2120097364 hasAuthorship W2120097364A5062908020 @default.
• W2120097364 hasAuthorship W2120097364A5069140624 @default.
• W2120097364 hasAuthorship W2120097364A5076387912 @default.
• W2120097364 hasAuthorship W2120097364A5076696730 @default.
• W2120097364 hasAuthorship W2120097364A5080038571 @default.
• W2120097364 hasBestOaLocation W21200973641 @default.
• W2120097364 hasConcept C150903083 @default.
• W2120097364 hasConcept C17991360 @default.
• W2120097364 hasConcept C185592680 @default.
• W2120097364 hasConcept C203014093 @default.
• W2120097364 hasConcept C207001950 @default.
• W2120097364 hasConcept C2777637488 @default.
• W2120097364 hasConcept C2778384902 @default.
• W2120097364 hasConcept C2779631663 @default.
• W2120097364 hasConcept C2780026444 @default.
• W2120097364 hasConcept C2780159080 @default.
• W2120097364 hasConcept C2780675486 @default.
• W2120097364 hasConcept C4937899 @default.
• W2120097364 hasConcept C501593827 @default.
• W2120097364 hasConcept C523546767 @default.
• W2120097364 hasConcept C54355233 @default.
• W2120097364 hasConcept C71924100 @default.
• W2120097364 hasConcept C86803240 @default.

• next