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• W2120125432 abstract "The effects of two beta 2-adrenoceptor agonists with different lipophilicities were studied on tremor induced by L-5-hydroxytryptophan (L-5-HTP) in pargyline- and carbidopa-pretreated rats. Tremor was recorded and analysed by an objective method based on accelerometry. Clenbuterol, a lipophilic beta 2-selective agonist, dose-dependently enhanced tremor intensity, whereas the hydrophilic beta 2-agonist terbutaline had no effect. The clenbuterol-induced enhancement of tremor was completely abolished by the beta 2-selective antagonist ICI 118,551 but unchanged by the beta 1-selective antagonist metoprolol. The results suggest that centrally located beta 2-adrenoceptors can mediate a modulation of 5-hydroxytryptamine-induced tremor in rats." @default.
• W2120125432 created "2016-06-24" @default.
• W2120125432 creator A5072265533 @default.
• W2120125432 date "1986-02-01" @default.
• W2120125432 modified "2023-09-25" @default.
• W2120125432 title "Central β-adrenoceptors can modulate 5-hydroxytryptamine-induced tremor in rats" @default.
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• W2120125432 doi "https://doi.org/10.1111/j.1476-5381.1986.tb10830.x" @default.
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