FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120153721> ?p ?o ?g. }

• W2120153721 endingPage "74" @default.
• W2120153721 startingPage "67" @default.
• W2120153721 abstract "Most orofacial clefts are nonsyndromic, isolated defects, and are classified into two groups: cleft lip (CL) with or without cleft palate and cleft palate (CP) only. Both are genetically complex traits, the genetic cause is stil elusive, it is genetically complex and enviromental factors are also responsible for the pathogenesis. Epithelial transformation to mesenchyme is an important event during the process of palatogenesis. Specifically, epithelial-mesenchymal transformation is thought to be critical for the disappearance of the seam and mesenchymal confluence. In palate formation, apoptosis is thought to facilitate adherence, or touching, of the opposing epithelium to form a seam. Apoptosis is important to sculpt the organelles in the body during development. We hypothesize that oxidative stress promotes epithelial cell apoptosis during palate formation. Oxidative stress occurs when the production of reactive oxygen species (ROS), including free radicals, exceeds the handling capability of intracellular antioxidant enzymes and extracellular antioxidant defenses. Excessive oxidative stress leads to peroxidative damage to cells, altered cellular function, and pathologic effects. Paraoxonase (PON) is a serum enzyme that is associated with antioxidant mechanism. We aim to determine the prevalance of the PON-1 192 polymorphisms in the patients and control groups. All cases included in this study are from the medical records of the Plastic, Reconstructive and Esthetic Clinic of Sisli Etfal Research and Training Hospital from August 2004 to January 2006. 50 nonsyndromic CL and CP cases and parent were analyzed. Blood specimens were collected in tubes containing EDTA, and DNA was prepared from leucoycte pellet by SDS lysis ammonium acetate extraction and ethanol precipitation. PON-1 genotypes were determined following PCR according to previously published protocols. Paraoxonase activities was measured according to Furlong et al. (1989). We evaluated the frequencies of polymorphisms of the PON1-192 gene in nonsyndromic cleft lip and cleft palate patients and in matched control subjects." @default.
• W2120153721 created "2016-06-24" @default.
• W2120153721 creator A5005191305 @default.
• W2120153721 creator A5012546736 @default.
• W2120153721 creator A5012756821 @default.
• W2120153721 creator A5012862425 @default.
• W2120153721 creator A5019612804 @default.
• W2120153721 creator A5028776930 @default.
• W2120153721 creator A5028782590 @default.
• W2120153721 creator A5029367310 @default.
• W2120153721 creator A5036759948 @default.
• W2120153721 date "2008-01-01" @default.
• W2120153721 modified "2023-10-18" @default.
• W2120153721 title "Paraoxonase-1 192 enzyme polymorphism in non-syndromic clefting: In patients and parents" @default.
• W2120153721 cites W1484170407 @default.
• W2120153721 cites W1520653771 @default.
• W2120153721 cites W1889850148 @default.
• W2120153721 cites W1981888346 @default.
• W2120153721 cites W1984119010 @default.
• W2120153721 cites W2006633413 @default.
• W2120153721 cites W2009985470 @default.
• W2120153721 cites W2021640816 @default.
• W2120153721 cites W2022809398 @default.
• W2120153721 cites W2033221133 @default.
• W2120153721 cites W2036383576 @default.
• W2120153721 cites W2043932712 @default.
• W2120153721 cites W2054605793 @default.
• W2120153721 cites W2058778432 @default.
• W2120153721 cites W2061816941 @default.
• W2120153721 cites W2077551742 @default.
• W2120153721 cites W2101154649 @default.
• W2120153721 cites W2109129927 @default.
• W2120153721 cites W2114623402 @default.
• W2120153721 cites W2118094114 @default.
• W2120153721 cites W2122751858 @default.
• W2120153721 cites W2139074554 @default.
• W2120153721 cites W2168439614 @default.
• W2120153721 cites W2323055834 @default.
• W2120153721 cites W586536889 @default.
• W2120153721 cites W623643567 @default.
• W2120153721 cites W71479514 @default.
• W2120153721 cites W2043107451 @default.
• W2120153721 hasPublicationYear "2008" @default.
• W2120153721 type Work @default.
• W2120153721 sameAs 2120153721 @default.
• W2120153721 citedByCount "0" @default.
• W2120153721 crossrefType "journal-article" @default.
• W2120153721 hasAuthorship W2120153721A5005191305 @default.
• W2120153721 hasAuthorship W2120153721A5012546736 @default.
• W2120153721 hasAuthorship W2120153721A5012756821 @default.
• W2120153721 hasAuthorship W2120153721A5012862425 @default.
• W2120153721 hasAuthorship W2120153721A5019612804 @default.
• W2120153721 hasAuthorship W2120153721A5028776930 @default.
• W2120153721 hasAuthorship W2120153721A5028782590 @default.
• W2120153721 hasAuthorship W2120153721A5029367310 @default.
• W2120153721 hasAuthorship W2120153721A5036759948 @default.
• W2120153721 hasConcept C126322002 @default.
• W2120153721 hasConcept C142724271 @default.
• W2120153721 hasConcept C16685009 @default.
• W2120153721 hasConcept C190283241 @default.
• W2120153721 hasConcept C2776151105 @default.
• W2120153721 hasConcept C2776509667 @default.
• W2120153721 hasConcept C2778004101 @default.
• W2120153721 hasConcept C2780942790 @default.
• W2120153721 hasConcept C48349386 @default.
• W2120153721 hasConcept C54355233 @default.
• W2120153721 hasConcept C55493867 @default.
• W2120153721 hasConcept C71924100 @default.
• W2120153721 hasConcept C86803240 @default.
• W2120153721 hasConcept C95444343 @default.
• W2120153721 hasConceptScore W2120153721C126322002 @default.
• W2120153721 hasConceptScore W2120153721C142724271 @default.
• W2120153721 hasConceptScore W2120153721C16685009 @default.
• W2120153721 hasConceptScore W2120153721C190283241 @default.
• W2120153721 hasConceptScore W2120153721C2776151105 @default.
• W2120153721 hasConceptScore W2120153721C2776509667 @default.
• W2120153721 hasConceptScore W2120153721C2778004101 @default.
• W2120153721 hasConceptScore W2120153721C2780942790 @default.
• W2120153721 hasConceptScore W2120153721C48349386 @default.
• W2120153721 hasConceptScore W2120153721C54355233 @default.
• W2120153721 hasConceptScore W2120153721C55493867 @default.
• W2120153721 hasConceptScore W2120153721C71924100 @default.
• W2120153721 hasConceptScore W2120153721C86803240 @default.
• W2120153721 hasConceptScore W2120153721C95444343 @default.
• W2120153721 hasIssue "1" @default.
• W2120153721 hasLocation W21201537211 @default.
• W2120153721 hasOpenAccess W2120153721 @default.
• W2120153721 hasPrimaryLocation W21201537211 @default.
• W2120153721 hasRelatedWork W1975406931 @default.
• W2120153721 hasRelatedWork W2042719185 @default.
• W2120153721 hasRelatedWork W2091294016 @default.
• W2120153721 hasVolume "7" @default.
• W2120153721 isParatext "false" @default.
• W2120153721 isRetracted "false" @default.
• W2120153721 magId "2120153721" @default.
• W2120153721 workType "article" @default.