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• W2120161520 abstract "From as early as the 1970s methotrexate has been associated with disseminated necrotizing leukoencephalopathy and other neurotoxic sequelae. Yet, a clear mechanism for methotrexate-induced neurotoxicity has not been established. The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate. The role of homocysteine as a possible mediator in methotrexate-induced neurotoxicity via direct endothelial injury is discussed." @default.
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• W2120161520 date "2010-02-02" @default.
• W2120161520 modified "2023-09-27" @default.
• W2120161520 title "SUBACUTE METHOTREXATE NEUROTOXICITY AND CEREBRAL VENOUS SINUS THROMBOSIS IN A 12-YEAR OLD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) C677T POLYMORPHISM: Homocysteine-Mediated Methotrexate Neurotoxicity via Direct Endothelial Injury" @default.
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• W2120161520 doi "https://doi.org/10.3109/08880010903341904" @default.
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