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• W2120170134 abstract "The complex transition from a single-cell to a multicellular life form during the formation of a fruiting body by the amoeba Dictyostelium discoideum is accompanied by a pulsatile collective signaling process that instigates chemotaxis of the constituent cells. Although the cells used for the analysis of this phenomenon are normally genetically identical (isogenic), it is not clear whether they are equally responsive to the waves of the signaling stimulus, nor is it clear how responses across the population influence collective cell behavior. Here, we found that isogenic Dictyostelium cells displayed differing sensitivities to the chemoattractant cyclic adenosine monophosphate (cAMP). Furthermore, the resulting signaling responses could be explained by a model in which cells are refractory to further stimulation for 5 to 6 min after the initial input and the signaling output is amplified, with the amplification threshold varying across the cells in the population. This pathway structure could explain intracellular amplification of the chemoattractant gradient during cell migration. The new model predicts that diverse cell responsiveness can facilitate collective cell behavior, specifically due to the presence of a small number of cells in the population with increased responsiveness that aid in propagating the initial cAMP signaling wave across the cell population." @default.
• W2120170134 created "2016-06-24" @default.
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• W2120170134 date "2012-02-28" @default.
• W2120170134 modified "2023-10-13" @default.
• W2120170134 title "Diverse Sensitivity Thresholds in Dynamic Signaling Responses by Social Amoebae" @default.
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• W2120170134 doi "https://doi.org/10.1126/scisignal.2002449" @default.
• W2120170134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5837804" @default.
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