FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120186670> ?p ?o ?g. }

• W2120186670 endingPage "1349" @default.
• W2120186670 startingPage "1343" @default.
• W2120186670 abstract "Sequential allergen desensitization provides temporary tolerance for allergic patients. We adapted a clinical protocol to desensitize human blood basophils ex vivo and investigated the mechanism and allergen specificity.We included 28 adult, grass allergic subjects. The optimal, activating allergen concentration was determined by measuring activated CD63(+) CD193(+) SS(Low) basophils in a basophil activation test with 8 log-dilutions of grass allergen. Basophils in whole blood were desensitized by incubation with twofold to 2.5-fold increasing allergen doses in 10 steps starting at 1 : 1000 of the optimal dose. Involvement of p38 mitogen-activated protein kinase (MAPK) was assessed after 3 min of allergen stimulation (n = 7). Allergen specificity was investigated by desensitizing cells from multi-allergic subjects with grass allergen and challenging with optimal doses of grass, birch, recombinant house dust mite (rDer p2) allergen or anti-IgE (n = 10).Desensitization reduced the fraction of blood basophils responding to challenge with an optimal allergen dose from a median (IQR) 81.0% (66.3-88.8) to 35.4% (19.8-47.1, P < 0.0001). CD63 MFI expression was reduced from 68 248 (29 336-92 001) to 30 496 (14 046-46 179, P < 0.0001). Basophils from multi-allergic subjects were desensitized with grass allergen. Challenge with grass allergen resulted in 39.6% activation (15.8-58.3). An unrelated challenge (birch, rDer p2 or anti-IgE) resulted in 53.4% activation (30.8-66.8, P = 0.16 compared with grass). Desensitization reduced p38 MAPK phosphorylation from a median 48.1% (15.6-92.8) to 26.1% (7.4-71.2, P = 0.047) and correlated with decrease in CD63 upregulation (n = 7, r > 0.79, P < 0.05).Desensitization attenuated basophil response rapidly and non-specifically at a stage before p38 MAPK phosphorylation." @default.
• W2120186670 created "2016-06-24" @default.
• W2120186670 creator A5000974372 @default.
• W2120186670 creator A5004432591 @default.
• W2120186670 creator A5015582099 @default.
• W2120186670 creator A5046982018 @default.
• W2120186670 creator A5070313094 @default.
• W2120186670 creator A5082035798 @default.
• W2120186670 date "2014-08-22" @default.
• W2120186670 modified "2023-10-06" @default.
• W2120186670 title "Sequential allergen desensitization of basophils is non-specific and may involve p38 MAPK" @default.
• W2120186670 cites W1572322088 @default.
• W2120186670 cites W1581018359 @default.
• W2120186670 cites W1604803930 @default.
• W2120186670 cites W1968037969 @default.
• W2120186670 cites W1981261016 @default.
• W2120186670 cites W1992347181 @default.
• W2120186670 cites W2006403509 @default.
• W2120186670 cites W2013360853 @default.
• W2120186670 cites W2014513314 @default.
• W2120186670 cites W2014581573 @default.
• W2120186670 cites W2018325300 @default.
• W2120186670 cites W2025563458 @default.
• W2120186670 cites W2025691876 @default.
• W2120186670 cites W2029887469 @default.
• W2120186670 cites W2036177573 @default.
• W2120186670 cites W2049946890 @default.
• W2120186670 cites W2064905678 @default.
• W2120186670 cites W2067038726 @default.
• W2120186670 cites W2073055496 @default.
• W2120186670 cites W2077324711 @default.
• W2120186670 cites W2078640401 @default.
• W2120186670 cites W2103240548 @default.
• W2120186670 cites W2133337209 @default.
• W2120186670 cites W2136199835 @default.
• W2120186670 cites W2137390371 @default.
• W2120186670 cites W2143918423 @default.
• W2120186670 cites W2151978148 @default.
• W2120186670 cites W2157079808 @default.
• W2120186670 cites W2164132449 @default.
• W2120186670 cites W2761465251 @default.
• W2120186670 doi "https://doi.org/10.1111/all.12482" @default.
• W2120186670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25040734" @default.
• W2120186670 hasPublicationYear "2014" @default.
• W2120186670 type Work @default.
• W2120186670 sameAs 2120186670 @default.
• W2120186670 citedByCount "18" @default.
• W2120186670 countsByYear W21201866702015 @default.
• W2120186670 countsByYear W21201866702016 @default.
• W2120186670 countsByYear W21201866702017 @default.
• W2120186670 countsByYear W21201866702018 @default.
• W2120186670 countsByYear W21201866702019 @default.
• W2120186670 countsByYear W21201866702020 @default.
• W2120186670 countsByYear W21201866702021 @default.
• W2120186670 countsByYear W21201866702022 @default.
• W2120186670 crossrefType "journal-article" @default.
• W2120186670 hasAuthorship W2120186670A5000974372 @default.
• W2120186670 hasAuthorship W2120186670A5004432591 @default.
• W2120186670 hasAuthorship W2120186670A5015582099 @default.
• W2120186670 hasAuthorship W2120186670A5046982018 @default.
• W2120186670 hasAuthorship W2120186670A5070313094 @default.
• W2120186670 hasAuthorship W2120186670A5082035798 @default.
• W2120186670 hasConcept C104317684 @default.
• W2120186670 hasConcept C126322002 @default.
• W2120186670 hasConcept C141105273 @default.
• W2120186670 hasConcept C145059251 @default.
• W2120186670 hasConcept C159654299 @default.
• W2120186670 hasConcept C170493617 @default.
• W2120186670 hasConcept C185592680 @default.
• W2120186670 hasConcept C203014093 @default.
• W2120186670 hasConcept C20518536 @default.
• W2120186670 hasConcept C207480886 @default.
• W2120186670 hasConcept C2776385711 @default.
• W2120186670 hasConcept C2777456892 @default.
• W2120186670 hasConcept C2778166374 @default.
• W2120186670 hasConcept C2779176990 @default.
• W2120186670 hasConcept C2779779143 @default.
• W2120186670 hasConcept C2780510475 @default.
• W2120186670 hasConcept C55493867 @default.
• W2120186670 hasConcept C71924100 @default.
• W2120186670 hasConceptScore W2120186670C104317684 @default.
• W2120186670 hasConceptScore W2120186670C126322002 @default.
• W2120186670 hasConceptScore W2120186670C141105273 @default.
• W2120186670 hasConceptScore W2120186670C145059251 @default.
• W2120186670 hasConceptScore W2120186670C159654299 @default.
• W2120186670 hasConceptScore W2120186670C170493617 @default.
• W2120186670 hasConceptScore W2120186670C185592680 @default.
• W2120186670 hasConceptScore W2120186670C203014093 @default.
• W2120186670 hasConceptScore W2120186670C20518536 @default.
• W2120186670 hasConceptScore W2120186670C207480886 @default.
• W2120186670 hasConceptScore W2120186670C2776385711 @default.
• W2120186670 hasConceptScore W2120186670C2777456892 @default.
• W2120186670 hasConceptScore W2120186670C2778166374 @default.
• W2120186670 hasConceptScore W2120186670C2779176990 @default.
• W2120186670 hasConceptScore W2120186670C2779779143 @default.
• W2120186670 hasConceptScore W2120186670C2780510475 @default.
• W2120186670 hasConceptScore W2120186670C55493867 @default.
• W2120186670 hasConceptScore W2120186670C71924100 @default.

• next