FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120188024> ?p ?o ?g. }

• W2120188024 abstract "An important step toward understanding the biological mechanisms underlying a complex disease is a refined understanding of its clinical heterogeneity. Relating clinical and molecular differences may allow us to define more specific subtypes of patients that respond differently to therapeutic interventions.We developed a novel unbiased method called diVIsive Shuffling Approach (VIStA) that identifies subgroups of patients by maximizing the difference in their gene expression patterns. We tested our algorithm on 140 subjects with Chronic Obstructive Pulmonary Disease (COPD) and found four distinct, biologically and clinically meaningful combinations of clinical characteristics that are associated with large gene expression differences. The dominant characteristic in these combinations was the severity of airflow limitation. Other frequently identified measures included emphysema, fibrinogen levels, phlegm, BMI and age. A pathway analysis of the differentially expressed genes in the identified subtypes suggests that VIStA is capable of capturing specific molecular signatures within in each group.The introduced methodology allowed us to identify combinations of clinical characteristics that correspond to clear gene expression differences. The resulting subtypes for COPD contribute to a better understanding of its heterogeneity." @default.
• W2120188024 created "2016-06-24" @default.
• W2120188024 creator A5007936433 @default.
• W2120188024 creator A5008555938 @default.
• W2120188024 creator A5018495347 @default.
• W2120188024 creator A5019318755 @default.
• W2120188024 creator A5022268127 @default.
• W2120188024 creator A5025090907 @default.
• W2120188024 creator A5034091916 @default.
• W2120188024 creator A5035524361 @default.
• W2120188024 creator A5037747729 @default.
• W2120188024 creator A5038976962 @default.
• W2120188024 creator A5046940384 @default.
• W2120188024 creator A5047902074 @default.
• W2120188024 creator A5048563533 @default.
• W2120188024 creator A5053929091 @default.
• W2120188024 creator A5065368239 @default.
• W2120188024 creator A5083270547 @default.
• W2120188024 date "2014-03-01" @default.
• W2120188024 modified "2023-10-18" @default.
• W2120188024 title "A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease" @default.
• W2120188024 cites W1596965334 @default.
• W2120188024 cites W1880464778 @default.
• W2120188024 cites W2005399105 @default.
• W2120188024 cites W2021583977 @default.
• W2120188024 cites W2062533676 @default.
• W2120188024 cites W2096401155 @default.
• W2120188024 cites W2122590281 @default.
• W2120188024 cites W2127951128 @default.
• W2120188024 cites W2130410032 @default.
• W2120188024 cites W2136858036 @default.
• W2120188024 cites W2138530225 @default.
• W2120188024 cites W2142096203 @default.
• W2120188024 cites W2158505521 @default.
• W2120188024 cites W2161377900 @default.
• W2120188024 cites W2161713331 @default.
• W2120188024 cites W2161823547 @default.
• W2120188024 cites W238668910 @default.
• W2120188024 cites W4230999035 @default.
• W2120188024 doi "https://doi.org/10.1186/1752-0509-8-s2-s8" @default.
• W2120188024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4101699" @default.
• W2120188024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25032995" @default.
• W2120188024 hasPublicationYear "2014" @default.
• W2120188024 type Work @default.
• W2120188024 sameAs 2120188024 @default.
• W2120188024 citedByCount "23" @default.
• W2120188024 countsByYear W21201880242014 @default.
• W2120188024 countsByYear W21201880242015 @default.
• W2120188024 countsByYear W21201880242016 @default.
• W2120188024 countsByYear W21201880242017 @default.
• W2120188024 countsByYear W21201880242018 @default.
• W2120188024 countsByYear W21201880242020 @default.
• W2120188024 countsByYear W21201880242021 @default.
• W2120188024 crossrefType "journal-article" @default.
• W2120188024 hasAuthorship W2120188024A5007936433 @default.
• W2120188024 hasAuthorship W2120188024A5008555938 @default.
• W2120188024 hasAuthorship W2120188024A5018495347 @default.
• W2120188024 hasAuthorship W2120188024A5019318755 @default.
• W2120188024 hasAuthorship W2120188024A5022268127 @default.
• W2120188024 hasAuthorship W2120188024A5025090907 @default.
• W2120188024 hasAuthorship W2120188024A5034091916 @default.
• W2120188024 hasAuthorship W2120188024A5035524361 @default.
• W2120188024 hasAuthorship W2120188024A5037747729 @default.
• W2120188024 hasAuthorship W2120188024A5038976962 @default.
• W2120188024 hasAuthorship W2120188024A5046940384 @default.
• W2120188024 hasAuthorship W2120188024A5047902074 @default.
• W2120188024 hasAuthorship W2120188024A5048563533 @default.
• W2120188024 hasAuthorship W2120188024A5053929091 @default.
• W2120188024 hasAuthorship W2120188024A5065368239 @default.
• W2120188024 hasAuthorship W2120188024A5083270547 @default.
• W2120188024 hasBestOaLocation W21201880241 @default.
• W2120188024 hasConcept C126322002 @default.
• W2120188024 hasConcept C142724271 @default.
• W2120188024 hasConcept C2776780178 @default.
• W2120188024 hasConcept C2779134260 @default.
• W2120188024 hasConcept C2992779976 @default.
• W2120188024 hasConcept C60644358 @default.
• W2120188024 hasConcept C70721500 @default.
• W2120188024 hasConcept C71924100 @default.
• W2120188024 hasConcept C86803240 @default.
• W2120188024 hasConceptScore W2120188024C126322002 @default.
• W2120188024 hasConceptScore W2120188024C142724271 @default.
• W2120188024 hasConceptScore W2120188024C2776780178 @default.
• W2120188024 hasConceptScore W2120188024C2779134260 @default.
• W2120188024 hasConceptScore W2120188024C2992779976 @default.
• W2120188024 hasConceptScore W2120188024C60644358 @default.
• W2120188024 hasConceptScore W2120188024C70721500 @default.
• W2120188024 hasConceptScore W2120188024C71924100 @default.
• W2120188024 hasConceptScore W2120188024C86803240 @default.
• W2120188024 hasIssue "S2" @default.
• W2120188024 hasLocation W21201880241 @default.
• W2120188024 hasLocation W21201880242 @default.
• W2120188024 hasLocation W21201880243 @default.
• W2120188024 hasLocation W21201880244 @default.
• W2120188024 hasLocation W21201880245 @default.
• W2120188024 hasLocation W21201880246 @default.
• W2120188024 hasLocation W21201880247 @default.
• W2120188024 hasOpenAccess W2120188024 @default.
• W2120188024 hasPrimaryLocation W21201880241 @default.
• W2120188024 hasRelatedWork W2024167655 @default.

• next