FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120197785> ?p ?o ?g. }

• W2120197785 endingPage "5055" @default.
• W2120197785 startingPage "5049" @default.
• W2120197785 abstract "ABSTRACT Most Staphylococcus aureus isolates produce either a serotype 5 (CP5) or 8 (CP8) capsular polysaccharide, and the CP antigens are targets for vaccine development. Since CP5 and CP8 have similar trisaccharide repeating units, it is important to identify an epitope shared by both CP5 and CP8. To characterize cross-reactivity between CP5 and CP8, the immunogenicity of CP5 and CP8 conjugate vaccines in mice and rabbits was evaluated by serological assays. Immune sera were also tested for functional activity by in vitro opsonophagocytic-killing assays and a murine bacteremia model. Antibodies to the CP5-cross-reactive material 197 (CRM197) conjugate vaccine bound only to purified CP5. In contrast, antibodies to the CP8-CRM conjugate vaccine reacted with CP8 and (to a lesser extent) CP5. De-O-acetylation of CP5 increased its reactivity with CP8 antibodies. Moreover, CP8 antibodies bound to Pseudomonas aeruginosa O11 lipopolysaccharide, which has a trisaccharide repeating unit similar to that of the S. aureus CPs. CP8-CRM antibodies mediated in vitro opsonophagocytic killing of S. aureus expressing CP5 or CP8, whereas CP5-CRM antibodies were serotype specific. Passive immunization with antiserum to CP5-CRM or CP8-CRM protected mice against bacteremia induced by a serotype 5 S. aureus isolate, suggesting that CP8-CRM elicits antibodies cross-reactive to CP5. The identification of epitopes shared by CP5 and CP8 may inform the rational design of a vaccine to protect against infections caused by CP5- or CP8-producing strains of S. aureus ." @default.
• W2120197785 created "2016-06-24" @default.
• W2120197785 creator A5016666139 @default.
• W2120197785 creator A5021849616 @default.
• W2120197785 creator A5076565717 @default.
• W2120197785 date "2014-12-01" @default.
• W2120197785 modified "2023-09-26" @default.
• W2120197785 title "Antibodies to Staphylococcus aureus Serotype 8 Capsular Polysaccharide React with and Protect against Serotype 5 and 8 Isolates" @default.
• W2120197785 cites W1831451590 @default.
• W2120197785 cites W1894456351 @default.
• W2120197785 cites W1896340693 @default.
• W2120197785 cites W1963668760 @default.
• W2120197785 cites W1965120579 @default.
• W2120197785 cites W1970232889 @default.
• W2120197785 cites W1973675012 @default.
• W2120197785 cites W1973872012 @default.
• W2120197785 cites W1985865348 @default.
• W2120197785 cites W1997880712 @default.
• W2120197785 cites W2004171730 @default.
• W2120197785 cites W2011531123 @default.
• W2120197785 cites W2020421790 @default.
• W2120197785 cites W2027988203 @default.
• W2120197785 cites W2032625989 @default.
• W2120197785 cites W2056599215 @default.
• W2120197785 cites W2062800186 @default.
• W2120197785 cites W2067508513 @default.
• W2120197785 cites W2073460279 @default.
• W2120197785 cites W2086046084 @default.
• W2120197785 cites W2086165685 @default.
• W2120197785 cites W2086333958 @default.
• W2120197785 cites W2089339244 @default.
• W2120197785 cites W2096522665 @default.
• W2120197785 cites W2110064610 @default.
• W2120197785 cites W2111872566 @default.
• W2120197785 cites W2113324151 @default.
• W2120197785 cites W2122011983 @default.
• W2120197785 cites W2129752888 @default.
• W2120197785 cites W2135761651 @default.
• W2120197785 cites W2138638997 @default.
• W2120197785 cites W2139576657 @default.
• W2120197785 cites W2140630847 @default.
• W2120197785 cites W2141707835 @default.
• W2120197785 cites W2143481959 @default.
• W2120197785 cites W2151124476 @default.
• W2120197785 cites W2154592972 @default.
• W2120197785 cites W2162753665 @default.
• W2120197785 cites W2170267077 @default.
• W2120197785 cites W4246948016 @default.
• W2120197785 doi "https://doi.org/10.1128/iai.02373-14" @default.
• W2120197785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4249259" @default.
• W2120197785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25245803" @default.
• W2120197785 hasPublicationYear "2014" @default.
• W2120197785 type Work @default.
• W2120197785 sameAs 2120197785 @default.
• W2120197785 citedByCount "13" @default.
• W2120197785 countsByYear W21201977852015 @default.
• W2120197785 countsByYear W21201977852016 @default.
• W2120197785 countsByYear W21201977852017 @default.
• W2120197785 countsByYear W21201977852019 @default.
• W2120197785 countsByYear W21201977852020 @default.
• W2120197785 countsByYear W21201977852022 @default.
• W2120197785 crossrefType "journal-article" @default.
• W2120197785 hasAuthorship W2120197785A5016666139 @default.
• W2120197785 hasAuthorship W2120197785A5021849616 @default.
• W2120197785 hasAuthorship W2120197785A5076565717 @default.
• W2120197785 hasBestOaLocation W21201977851 @default.
• W2120197785 hasConcept C10389963 @default.
• W2120197785 hasConcept C147483822 @default.
• W2120197785 hasConcept C159047783 @default.
• W2120197785 hasConcept C159654299 @default.
• W2120197785 hasConcept C195616568 @default.
• W2120197785 hasConcept C203014093 @default.
• W2120197785 hasConcept C2779142602 @default.
• W2120197785 hasConcept C2779489039 @default.
• W2120197785 hasConcept C3020064264 @default.
• W2120197785 hasConcept C45189115 @default.
• W2120197785 hasConcept C523546767 @default.
• W2120197785 hasConcept C54355233 @default.
• W2120197785 hasConcept C86803240 @default.
• W2120197785 hasConcept C89423630 @default.
• W2120197785 hasConcept C91523082 @default.
• W2120197785 hasConceptScore W2120197785C10389963 @default.
• W2120197785 hasConceptScore W2120197785C147483822 @default.
• W2120197785 hasConceptScore W2120197785C159047783 @default.
• W2120197785 hasConceptScore W2120197785C159654299 @default.
• W2120197785 hasConceptScore W2120197785C195616568 @default.
• W2120197785 hasConceptScore W2120197785C203014093 @default.
• W2120197785 hasConceptScore W2120197785C2779142602 @default.
• W2120197785 hasConceptScore W2120197785C2779489039 @default.
• W2120197785 hasConceptScore W2120197785C3020064264 @default.
• W2120197785 hasConceptScore W2120197785C45189115 @default.
• W2120197785 hasConceptScore W2120197785C523546767 @default.
• W2120197785 hasConceptScore W2120197785C54355233 @default.
• W2120197785 hasConceptScore W2120197785C86803240 @default.
• W2120197785 hasConceptScore W2120197785C89423630 @default.
• W2120197785 hasConceptScore W2120197785C91523082 @default.
• W2120197785 hasIssue "12" @default.
• W2120197785 hasLocation W21201977851 @default.

• next