FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120200123> ?p ?o ?g. }

• W2120200123 endingPage "19149" @default.
• W2120200123 startingPage "19144" @default.
• W2120200123 abstract "Nitrite has emerged as an endogenous signaling molecule with potential therapeutic implications for cardiovascular disease. Steady-state levels of nitrite are derived in part from dietary sources; therefore, we investigated the effects of dietary nitrite and nitrate supplementation and deficiency on NO homeostasis and on the severity of myocardial ischemia-reperfusion (MI/R) injury. Mice fed a standard diet with supplementation of nitrite (50 mg/liter) in their drinking water for 7 days exhibited significantly higher plasma levels of nitrite, exhibited significantly higher myocardial levels of nitrite, nitroso, and nitrosyl-heme, and displayed a 48% reduction in infarct size (Inf) after MI/R. Supplemental nitrate (1 g/liter) in the drinking water for 7 days also increased blood and tissue NO products and significantly reduced Inf. A time course of ischemia-reperfusion revealed that nitrite was consumed during the ischemic phase, with an increase in nitroso/nitrosyl products in the heart. Mice fed a diet deficient in nitrite and nitrate for 7 days exhibited significantly diminished plasma and heart levels of nitrite and NO metabolites and a 59% increase in Inf after MI/R. Supplementation of nitrite in the drinking water for 7 days reversed the effects of nitrite deficiency. These data demonstrate the significant influence of dietary nitrite and nitrate intake on the maintenance of steady-state tissue nitrite/nitroso levels and illustrate the consequences of nitrite deficiency on the pathophysiology of MI/R injury. Therefore, nitrite and nitrate may serve as essential nutrients for optimal cardiovascular health and may provide a treatment modality for cardiovascular disease." @default.
• W2120200123 created "2016-06-24" @default.
• W2120200123 creator A5009451038 @default.
• W2120200123 creator A5012532104 @default.
• W2120200123 creator A5014186027 @default.
• W2120200123 creator A5055451006 @default.
• W2120200123 creator A5077535251 @default.
• W2120200123 creator A5089891181 @default.
• W2120200123 date "2007-11-27" @default.
• W2120200123 modified "2023-10-16" @default.
• W2120200123 title "Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury" @default.
• W2120200123 cites W1269597682 @default.
• W2120200123 cites W1574625282 @default.
• W2120200123 cites W1973470186 @default.
• W2120200123 cites W1974251201 @default.
• W2120200123 cites W1978220492 @default.
• W2120200123 cites W1985227130 @default.
• W2120200123 cites W1986703419 @default.
• W2120200123 cites W2005466083 @default.
• W2120200123 cites W2012073884 @default.
• W2120200123 cites W2016139728 @default.
• W2120200123 cites W2032477413 @default.
• W2120200123 cites W2033357754 @default.
• W2120200123 cites W2039979152 @default.
• W2120200123 cites W2040324649 @default.
• W2120200123 cites W2040852689 @default.
• W2120200123 cites W2042105758 @default.
• W2120200123 cites W2043562592 @default.
• W2120200123 cites W2043897455 @default.
• W2120200123 cites W2049505174 @default.
• W2120200123 cites W2051071984 @default.
• W2120200123 cites W2052871899 @default.
• W2120200123 cites W2055713391 @default.
• W2120200123 cites W2068395093 @default.
• W2120200123 cites W2092145002 @default.
• W2120200123 cites W2092175186 @default.
• W2120200123 cites W2094949453 @default.
• W2120200123 cites W2096257801 @default.
• W2120200123 cites W2098453482 @default.
• W2120200123 cites W2100657323 @default.
• W2120200123 cites W2105080404 @default.
• W2120200123 cites W2105104689 @default.
• W2120200123 cites W2106922430 @default.
• W2120200123 cites W2112012050 @default.
• W2120200123 cites W2122737708 @default.
• W2120200123 cites W2125647807 @default.
• W2120200123 cites W2128346933 @default.
• W2120200123 cites W2132704929 @default.
• W2120200123 cites W2133542546 @default.
• W2120200123 cites W2148703298 @default.
• W2120200123 cites W2149980494 @default.
• W2120200123 cites W2319869190 @default.
• W2120200123 cites W99967797 @default.
• W2120200123 doi "https://doi.org/10.1073/pnas.0706579104" @default.
• W2120200123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2141922" @default.
• W2120200123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18025468" @default.
• W2120200123 hasPublicationYear "2007" @default.
• W2120200123 type Work @default.
• W2120200123 sameAs 2120200123 @default.
• W2120200123 citedByCount "314" @default.
• W2120200123 countsByYear W21202001232012 @default.
• W2120200123 countsByYear W21202001232013 @default.
• W2120200123 countsByYear W21202001232014 @default.
• W2120200123 countsByYear W21202001232015 @default.
• W2120200123 countsByYear W21202001232016 @default.
• W2120200123 countsByYear W21202001232017 @default.
• W2120200123 countsByYear W21202001232018 @default.
• W2120200123 countsByYear W21202001232019 @default.
• W2120200123 countsByYear W21202001232020 @default.
• W2120200123 countsByYear W21202001232021 @default.
• W2120200123 countsByYear W21202001232022 @default.
• W2120200123 countsByYear W21202001232023 @default.
• W2120200123 crossrefType "journal-article" @default.
• W2120200123 hasAuthorship W2120200123A5009451038 @default.
• W2120200123 hasAuthorship W2120200123A5012532104 @default.
• W2120200123 hasAuthorship W2120200123A5014186027 @default.
• W2120200123 hasAuthorship W2120200123A5055451006 @default.
• W2120200123 hasAuthorship W2120200123A5077535251 @default.
• W2120200123 hasAuthorship W2120200123A5089891181 @default.
• W2120200123 hasBestOaLocation W21202001231 @default.
• W2120200123 hasConcept C126322002 @default.
• W2120200123 hasConcept C134018914 @default.
• W2120200123 hasConcept C178790620 @default.
• W2120200123 hasConcept C185592680 @default.
• W2120200123 hasConcept C2776179834 @default.
• W2120200123 hasConcept C2776384668 @default.
• W2120200123 hasConcept C2910772780 @default.
• W2120200123 hasConcept C519581460 @default.
• W2120200123 hasConcept C541997718 @default.
• W2120200123 hasConcept C55493867 @default.
• W2120200123 hasConcept C71924100 @default.
• W2120200123 hasConceptScore W2120200123C126322002 @default.
• W2120200123 hasConceptScore W2120200123C134018914 @default.
• W2120200123 hasConceptScore W2120200123C178790620 @default.
• W2120200123 hasConceptScore W2120200123C185592680 @default.
• W2120200123 hasConceptScore W2120200123C2776179834 @default.
• W2120200123 hasConceptScore W2120200123C2776384668 @default.
• W2120200123 hasConceptScore W2120200123C2910772780 @default.

• next